Effect of different physical activity training methods on epilepsy

Zhang, Chen qi; Li, Hong Yan; Wan, Yong; Bai, Xue; Gan, Lu; Sun, Hong

doi:10.1097/md.0000000000029085

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…There remain natural ways to increase endogenous dynorphin levels in the brain such as exercise, and some literature (109,110) have supported gentle exercise such as aerobics to significantly decrease the number of seizures in some people. This has not been directly correlated to dynorphin and is likely more complex than decreasing seizures due to increased dynorphin levels from exercise, however, it engages in the challenge to naturally reduce seizures.…”

Section: Therapeutic Implications and Direction Of Future Researchmentioning

confidence: 99%

Opioids, microglia, and temporal lobe epilepsy

Lankhuijzen,

Ridler

2024

Front. Neurol.

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A lack of treatment options for temporal lobe epilepsy (TLE) demands an urgent quest for new therapies to recover neuronal damage and reduce seizures, potentially interrupting the neurotoxic cascades that fuel hyper-excitability. Endogenous opioids, along with their respective receptors, particularly dynorphin and kappa-opioid-receptor, present as attractive candidates for controlling neuronal excitability and therapeutics in epilepsy. We perform a critical review of the literature to evaluate the role of opioids in modulating microglial function and morphology in epilepsy. We find that, in accordance with anticonvulsant effects, acute opioid receptor activation has unique abilities to modulate microglial activation through toll-like 4 receptors, regulating downstream secretion of cytokines. Abnormal activation of microglia is a dominant feature of neuroinflammation, and inflammatory cytokines are found to aggravate TLE, inspiring the challenge to alter microglial activation by opioids to suppress seizures. We further evaluate how opioids can modulate microglial activation in epilepsy to enhance neuroprotection and reduce seizures. With controlled application, opioids may interrupt inflammatory cycles in epilepsy, to protect neuronal function and reduce seizures. Research on opioid-microglia interactions has important implications for epilepsy and healthcare approaches. However, preclinical research on opioid modulation of microglia supports a new therapeutic pathway for TLE.

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Section: Therapeutic Implications and Direction Of Future Researchmentioning

confidence: 99%

Opioids, microglia, and temporal lobe epilepsy

Lankhuijzen,

Ridler

2024

Front. Neurol.

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“…Disamping itu, aktivitas fisik akan memberikan dampak positif terhadap psikologis pasien dengan peningkatan mood, mengurangi stress dan memunculkan rasa bahagia sehingga angka kekambuhan bisa ditekan 11 . Gaya hidup yang monoton dan tidak banyak bergerak akan mempengaruhi fisik seseorang dan persepsi kualitas hidup yang rendah 12 . Aktivitas fisik juga merupakan strategi manajemen pengendalian diri yang dapat membantu mengurangi frekuensi kejang, meningkatkan harga diri dan interaksi social, meningkatkan kesejahteraan fisik, optimalisasi kesehatan mental dan mengurangi beban bagi penderita epilepsi.…”

Section: Diskusi Aktivitas Fisikunclassified

Peningkatan Kualitas Hidup Melalui Physical and Spiritual Treatment Pada Pasien Dengan Epilepsi : Studi Kasus

Haryanti

Sundari

Madani

2022

SPICM

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Epilepsi yang dideskripsikan pada laporan kasus ini adalah epilepsi idiopatik dengan kejang tonik klonik. Seorang perempuan berusia 18 tahun memiliki riwayat kejang pertama kali sejak usia 6 bulan, muncul perubahan perilaku pada usia 5 tahun dan sejak itu kemudian didiagnosis epilepsi. Pada usia 16 tahun, pasien memutuskan untuk putus sekolah karena malu dengan teman-temannya. Sejak saat itu pasien hanya beraktivitas dirumah, dengan rutin mengkonsumsi obat anti kejang yaitu bamgetol tablet 200 mg dua kali sehari. Pasien sering mengatakan kepada orang tuanya bagaimana dia bisa melanjutkan kehidupannya jika tidak ada bapak dan ibunya. Pasien merasa sedih karena kehilangan teman dekatnya dan tidak lagi bisa mengikuti aktivitas diluar rumah karena takut kejangnya kambuh. Skor yang dihasilkan pada 4 domain kualitas hidup adalah 40 yang berarti pasien memiliki kualitas hidup yang tidak baik. Intervensi yang diberikan berupa aktivitas fisik ringan yang disukai pasien dan pendampingan spiritual menggunakan pendekatan rukun islam. Setelah 1,5 bulan, pasien menunjukkan perubahan sikap, pasien tampak lebih bersemangat menjalani hari-hari, dua sahabat dekatnya saling bergantian mengunjungi pada hari libur dan melakukan kegiatan yang disukai pasien secara bersama-sama, aktivitas kejang menurun dan hasil pengkajian kualitas hidup berada pada skor 75. Peran perawat terhadap upaya peningkatan kualitas hidup pasien harus mendapat prioritas utama, karena inti dari penatalaksanaan kasus terminal adalah pada bagaimana optimalisasi aspek psikologis dan spiritualitasnya, terutama dalam upaya pencapaian akhir yang husnul khatimah.

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Is a History of Seizures an Important Risk Factor for Sudden Cardiac Death in Young Athletes?

Paratz

Scheffer

Semsarian

2023

Curr Treat Options Cardio Med

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Purpose of Review This review examines the significance of seizures in young athletes and the complex inter-relationship between seizures, epilepsy, and sudden cardiac death. Recent Findings A history of seizures may reflect a diagnosis of epilepsy, which should be medically optimized for athletic participation. Epilepsy is associated with sudden unexplained cardiac death (sudden unexplained death in epilepsy, SUDEP), with multiple genetic links identified to define some patients as experiencing a “cardiocerebral channelopathy.” It is also important to consider that a history of seizures may reflect a misdiagnosis of cardiac syncope, requiring careful cardiac evaluation and risk stratification. Summary A history of seizures in a young athlete is important to characterize fully and investigate as required. The association of seizures with young sudden cardiac death is still under investigation.

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Effect of different physical activity training methods on epilepsy

Cited by 4 publications

References 26 publications

Opioids, microglia, and temporal lobe epilepsy

Opioids, microglia, and temporal lobe epilepsy

Peningkatan Kualitas Hidup Melalui Physical and Spiritual Treatment Pada Pasien Dengan Epilepsi : Studi Kasus

Is a History of Seizures an Important Risk Factor for Sudden Cardiac Death in Young Athletes?

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