Effect of different masticatory functional demands on the 3D mandibular condyle morphology of growing rats using posterior bite-blocks

Denes, Balazs Jozsef; Lazzarotto, Benjamin; Bresin, Andrea; Kiliaridis, Stavros

doi:10.1093/ejo/cjx072

Cited by 5 publications

(11 citation statements)

References 18 publications

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“…Young rats were 4 weeks old, which corresponds to the initial period of usage of the teeth, which finish erupting at 21 days, 36 while adult rats were 26 weeks old. Many studies report similar ages when evaluating young and adult rats 10–18,21,22,27–29,31,32 …”

Section: Discussionmentioning

confidence: 99%

“…The scans were then reconstructed using the integrated scanner software by choosing the condylar process area as the region of interest with a voxel size 30 μm and a field of view (FOV) of 15.4 mm. The scans were then exported in DICOM format, analysed with Osirix® image analysis software, Geneva, Switzerland, and reoriented according to the base of the condylar process, defined by the AB line passing through the deepest points of the posterior mandibular notches, as previously described 28 (Figure 1). The following measurements were studied: condylar base width, condylar process height and condylar cross-sectional surface.…”

Section: Micro-ctmentioning

confidence: 99%

“…Micro‐CT has also been used to study condylar changes on rats with a diminished masticatory function 22,27–30 . To the best of our knowledge, however, there are only two references in the literature 31,32 in which an in vivo micro‐CT examination was used to examine the effects of a decreased masticatory function on rats, induced by molar extraction and soft diet.…”

Section: Introductionmentioning

confidence: 99%

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Mandibular condyle changes in rats with unilateral masticatory function

Carli

Lagou

Kiliaridis

et al. 2022

Orthod Craniofacial Res

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Objective: Certain malocclusions or unilateral tooth loss can lead to asymmetric functional load of the two mandibular sides during mastication and induce skeletal asymmetries to the condylar process of growing individuals. However, in adults, asymmetric function may have a different impact. The aim of the present study was to investigate three-dimensionally the effects of unilateral masticatory function on the condylar process morphology in growing and adult rats and the adaptive processes to differential condylar loading. Materials and Methods:Fifty-six growing and adult Wistar rats aged 4 and 26 weeks respectively were obtained. The maxillary right molars of the experimental animals were extracted and all animals were followed for 12 weeks. Three-dimensional images were obtained by an in-vivo microcomputed tomography (micro-CT) examination. The following measurements were studied: condylar process height, condylar base width, and condylar cross-sectional surface.Results: While no differences were found with regards to condylar process height and base width, the cross-section of the condyle on the extraction side did not increase during growth in the young rats. No such differences were found in adults. Young rats had statistically significantly shorter condylar height, base width and cross-sectional surface than the adult rats and showed significant growth of these structures during the experimental period. Conclusion:Condylar height and base width growth are not hindered by reduced occlusal function, contrary to the average cross-sectional surface, which implies that the condyle form of growing individuals becomes thinner while maintaining its length, in the absence of occlusal stimuli. The condyle of adult rats with extractions is less affected by occlusion changes.

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Section: Discussionmentioning

confidence: 99%

Section: Micro-ctmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mandibular condyle changes in rats with unilateral masticatory function

Carli

Lagou

Kiliaridis

et al. 2022

Orthod Craniofacial Res

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“…Our study, to our knowledge, is the first to investigate changes in mouse craniofacial morphology due to prolonged, multi-generational exposure to SD using 3D GMA. Prior studies using animal models have analyzed craniofacial adaptation to SD and load reduction in a single generation using 2D linear measurements ( Corruccini and Beecher, 1982 ; Kiliaridis et al, 1985 ; Dias et al, 2011 ; Denes et al, 2013 , 2018 ; Anderson et al, 2014 ; Goto et al, 2015 ; Kono et al, 2017 ). Mice are preferred models because of the use of isogenic strains, tight environmental control of multiple specimens, relatively short gestation periods, and extensive information from prior genetic and environmental studies ( Fish, 2016 ; Liu, 2016 ; Van Otterloo et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Multi-Generational Soft Diet Consumption on Mouse Craniofacial Morphology

et al. 2020

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Variations in craniofacial morphology may arise as a result of adaptation to different environmental factors such as soft diet (SD), which lessens functional masticatory load. Prior studies have shown that changes in the masticatory muscle function associated with a switch to short-term SD led to changes in craniofacial morphology and alveolar bone architecture. However, the long-term effects of SD and the associated adaptive changes in craniofacial shape are unclear. Our novel study set out to profile prospective skull changes in mice fed with SDs over multiple generations using three-dimensional (3D) geometric morphometric analysis (GMA). Our results revealed that short-term SD consumption led to a significant decrease in craniofacial size, along with numerous shape changes. Long-term SD consumption over 15 continuous generations was not associated with changes in craniofacial size; however, shape analysis revealed mice with shortened crania and mandibles in the anteroposterior dimension, as well as relative widening in the transverse dimension compared to the average shape of all mice analyzed in our study. Moreover, changes in shape and size associated with different functional loads appeared to be independent-shape changes persisted after diets were switched for one generation, whereas size decreased after one generation and then returned to baseline size. Our study is the first to study the role of prolonged, multi-generational SD consumption in the determination of craniofacial size and shape.

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“…Conversely, Larsson and Ronnerman (1981), as well as Janson and Hasund (1981), concluded that patients subjected to orthodontic treatment are not prone to temporomandibular disorders in later life. A recent study by Denes et al (2018) demonstrated that using a bite-block appliance leads to weak masticatory muscle function at all regions of the condylar process. Conversely, according to Maillard et al (2017), neuromuscular molding appliances have positive surgical, aesthetical, functional and socio-economic effects on the patients undergoing orthodontic treatment.…”

Section: Introductionmentioning

confidence: 99%

An Overview of Orthodontic Functional Analysis

Aksoy

Abdulhussein²

2021

Black Sea Journal of Health Science

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Functional analysis is mainly concerned with the functional units of the masticatory system. Given the gradual development and indirect accumulative effect of occlusal disharmonies, functional analysis could be considered the only method that can demonstrate malocclusions and their possible connections with functional disturbances and disorders. Thus, analysis of the functional units of the stomatognathic system should follow the clinical examination of the various components of the craniofacial complex in static and dynamic relationship, to achieve a comprehensive orthodontic treatment. Assessment of the temporomandibular joints (TMJs) is one of the major elements of the functional analysis, and one of the long-term objectives of orthodontic treatment is to obtain an optimal function and health of the TMJs and masticatory system. Therefore, many studies discuss the condition of the TMJs in the pre-and post-treatment phases, regarding the disorders that may be present or will develop in the future. In this context, the objective of this literature overview is to explain the need of the functional analysis in modern orthodontics and the parts and components involved in the examination of the functional units of the stomatognathic system.

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Effect of different masticatory functional demands on the 3D mandibular condyle morphology of growing rats using posterior bite-blocks

Cited by 5 publications

References 18 publications

Mandibular condyle changes in rats with unilateral masticatory function

Mandibular condyle changes in rats with unilateral masticatory function

Effects of Multi-Generational Soft Diet Consumption on Mouse Craniofacial Morphology

An Overview of Orthodontic Functional Analysis

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