2021
DOI: 10.1016/j.ces.2021.116833
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Effect of different good solvents in flash nano-precipitation via multi-scale population balance modeling-CFD coupling approach

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Cited by 12 publications
(6 citation statements)
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“…Each inlet stream is divided into 3 substreams in 120 μm wide microchannels, followed by the convergence of the 6 substreams to a single, 300 μm wide pinhole. We selected two very different approaches to quantify the mixing speeds in these systems: modeling using computational fluid dynamics (CFD) , and indirect measurements using competitive reactions.…”
Section: Resultsmentioning
confidence: 99%
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“…Each inlet stream is divided into 3 substreams in 120 μm wide microchannels, followed by the convergence of the 6 substreams to a single, 300 μm wide pinhole. We selected two very different approaches to quantify the mixing speeds in these systems: modeling using computational fluid dynamics (CFD) , and indirect measurements using competitive reactions.…”
Section: Resultsmentioning
confidence: 99%
“…In consequence, the mixing parameters were strongly improved, from dropwise addition to the use of specifically designed mixers using collision of flows or herringbone mixers. , In these cases, it has been observed that improved mixing leads in general to smaller NPs with narrower size distributions. , Related to this are various parameters that indirectly influence the kinetics of particle formation. Among these are the concentration of polymer and load , and the organic solvent used. , While the former influences the diffusion distances, the latter influences the limit of solubility of the polymer in the water–solvent mixture.…”
Section: Introductionmentioning
confidence: 99%
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“…In order to obtain the solution of the PBE, different methods can be employed for different industrial applications. [1][2][3] The quadrature-based moments method (QBMM) accurately captures the dynamics of the particle size distribution while reducing computational complexity compared to other methods, attracting more attention. 4 The most popular QBMM is the quadrature method of moments (QMOM), [5][6][7][8] whereas it is worth mentioning that other moment methods exist beyond QBMM, as, for example, the Taylorseries expansion method of moment (TEMOM).…”
Section: Introductionmentioning
confidence: 99%
“…1,2 Computer modeling techniques can greatly enhance the comprehension of the way the molecules organize themselves in a liquid. [11][12][13][14] Molecular simulations can provide valuable insight into the relationship between molecular properties and structural organization that are relevant for a better understanding of the behavior of food emulsions, including the miscibility/immiscibility of liquids, the formation of surfactant micelles, the adsorption and displacement of emulsifiers at interfaces, the transport of nonpolar molecules through aqueous phases, the conformation and flexibility of biopolymers in solution, polymer interactions, and the formation of gels. [15][16][17][18][19][20][21][22][23][24] The first step in a molecular simulation is to define the characteristics of the molecules involved (e.g., size, shape, flexibility, and polarity) and the nature of the intermolecular pair potentials that act between them, making a number of simplifying assumptions as a compromise between the model reliability and a reasonable computational time.…”
Section: Introductionmentioning
confidence: 99%