Effect of different foods on the acidity of the gastric contents in patients with duodenal ulcer: Part II Effect of varying the size and frequency of meals

Babouris, N.; Fletcher, Janet; Lennard-Jones, J E

doi:10.1136/gut.6.2.118

Cited by 17 publications

(4 citation statements)

References 4 publications

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“…Serial measurements of intragastric pH are suitable for recording the effects of diet or drugs on gastric acidity (Nichol, 1939;James and Pickering, 1949;Rowlands et al, 1952;Atkinson, 1954;Kasich and Agyros, 1958;Bingle and Lennard-Jones, 1960;Vakil et al, 1963;Lennard-Jones and Babouris, 1965;Babouris et al, 1965). The major advantage of this technique is that data can be collected during a reasonably long period in subjects whose diet and activity are similar to normal life.…”

Section: Discussionmentioning

confidence: 99%

Effect of cimetidine on 24-hour intragastric acidity in normal subjects.

Pounder¹,

Williams²,

Milton-Thompson³

et al. 1976

Gut

111

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SUMMARY The effect of H2-receptor blockade on intragastric acidity was studied in nine normal males. The pH of their gastric contents was measured at hourly daytime and two hourly nighttime intervals for 48 hours. The subjects ate identical meals, drank identical volumes of fluid, and smoked the same number of cigarettes during the two study days. Their physical activity was unrestricted in a ward environment. Blood cimetidine and plasma gastrin were measured in serial blood samples. The nine subjects were treated in random sequence with cimetidine 0 8-1 *0 g on one day and placebo capsules on the other. The drug was given in four divided doses: four subjects received it before, and five after, the three main meals. All took the fourth dose at bedtime. Replicate studies in an additional subject given placebo on both study days showed good reproducibility (r = 0O80, p < 0 01). Cimetidine therapy decreased intragastric acidity in all nine subjects. The decrease was similar in the two groups taking the drug before or after meals, mean 24 h intragastric hydrogen ion activity being lowered by 70 and 72 % respectively. Nocturnal anacidity was recorded in only two of 45 samples. Administration of cimetidine before meals produced earlier and higher drug blood levels than post-prandial medication, but when it was taken after food the blood levels were highest at the time when the buffer capacity of the food was waning. Blood concentrations of cimetidine exceeded the secretory IC50 level for most of the time between doses. The results show that cimetidine 0 8-1 .0 g/day in four divided doses produces a striking and consistent decrease of intragastric acidity. Although variation in the timing of the dose in relation to meals did not affect the decrease of acidity, the absorption data suggest that patients should take the drug after meals.Cimetidine is a new histamine H2-receptor antagonist, which in man has a potency similar to metiamide for the inhibition of acid secretion stimulated by pentagastrin or food (Black et al., 1972;Black et al., 1973;Mainardi et al., 1974;Brimblecombe et al., 1975;Burland et al., 1975;Pounder et al., 1975a;Henn et al., 1975;.The thiourea residue in metiamide, which is thought to have been responsible for the reversible marrow depression that occurred in seven patients receiving the drug, has been replaced by a cyanoguanidine moiety in cimetidine.In order to determine the optimal time of medication before starting clinical trials of the new com-

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Section: Discussionmentioning

confidence: 99%

Effect of cimetidine on 24-hour intragastric acidity in normal subjects.

Pounder¹,

Williams²,

Milton-Thompson³

et al. 1976

Gut

111

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show abstract

“…A combined study by Babouris et al (1965) on changing both meal size and frequency in humans with duodenal ulcers showed that frequent small meals gave less variation in pre-and post-meal gastric pH because of more even stimulation of acid production.…”

Section: Meul Size and Frequencymentioning

confidence: 99%

Nutritional Regulation of Gastric Secretion, Digestion and Emptying

Low¹

1990

Nutr. Res. Rev.

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“…No signifi cant difference was found in radiological healing of the ulcer or in clinical response during the 6-month follow-up period. Lennard-Jones et al (8), Len nar d-J ones and Barbouris (7) and Barbouris et al (1), in London, studying the effect of various diets on the pH of gastric contents of patients with duodenal ulcer found that under hyperproteic diets, gastric acidity was kept discreetly lower than under hyperglucidic meals, although the difference observed was not statistically significant. Buchman et al (2) treated 103 patients with radiologically confirmed duodenal ulcer, 50 of them receiving a bland diet and the remaining 53 having normal meals.…”

Section: Discussionmentioning

confidence: 99%

“…Several authors (1,2,4,7,8) have lately been questioning the possible beneficial effects of such type of diet as compared with normal or freely chosen diets. In a previous paper (4), we studied the effect of diets of different composi tion (hyperproteic, hyperglucidic, hyperlipidic, normal and bland) on the acidity of gastric contents.…”

mentioning

confidence: 99%