Effect of Different Flavonoids on Collagen Synthesis in Human Fibroblasts

Stipčević, Tamara; Piljac, Jasenka; Berghe, Dirk Vanden

doi:10.1007/s11130-006-0006-8

Cited by 61 publications

(56 citation statements)

References 22 publications

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“…Further, Vitamin C, that is required for collagen formation and maturation, is up-regulated in flavonoid-treated wound [35]. Flavonoids have also been shown to increase the viability and proliferation of fibroblasts [36]. Tannins have antioxidant effect and may act in similar fashion to promote collagen deposition [37].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Ethanolic Extract of Cyanotis Cristata Leaves Applied Topically on Wound Healing in Wistar Rats

Pathak

Shenoy

Kiran

et al. 2017

Asian J Pharm Clin Res

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Objective: The objective of this study was to assess the effect of ethanolic extract of Cyanotis cristata leaves when applied topically on healing of wound in Wistar rats. Methods:C. cristata leaves were evaluated for its effect on healing of wound in three models, namely, incision, excision, and burn wound. Each model included five groups, each consisting of 6 rats. The five groups were as follows: Group I rats (control and ointment base), Group II rats (standard and silver sulfadiazine), and Group III, Group IV, Group V (treated with C. cristata extract ointment of 0.5%, 1%, and 2%, respectively). Variables evaluated included breaking strength in incision wound while it was contraction rate and epithelialization in excision and burn wound. One-way analysis of variance and Tukey's post hoc test was used to analyze data. Result:In incision wound, breaking strength in test group was significantly increased (p<0.001) as compared to control. In excision and burn wound of test group, time to epithelialization and contraction rate was significantly decreased (p<0.001). The granulation tissue from excision and burn wound showed increased collagen and less inflammatory cells in test groups in comparison to the control. Conclusion:The ethanolic extract of leaves of C. cristata, when applied topically, enhanced wound strength and accelerated healing of incision, excision, and burn wounds in rats.

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Section: Discussionmentioning

confidence: 99%

“…Further, it also induces several metalloproteinases, which degrades extracellular matrix, thereby facilitating migration [40]. Furthermore, both tannins and flavonoids increase collagen deposition [34][35][36][37] that provides scaffolding for the process of epithelialization [41].…”

Section: Pathak Et Almentioning

confidence: 99%

Effect of Ethanolic Extract of Cyanotis Cristata Leaves Applied Topically on Wound Healing in Wistar Rats

Pathak

Shenoy

Kiran

et al. 2017

Asian J Pharm Clin Res

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“…Among them, 4'-hydroxyflavanone, a synthetic analogue of flavanones, is involved in various biological activities and physiological effects such as endothelium-independent full vasorelaxing efficacy on rat aortic rings, 11 aromatase inhibitor properties, 12 decreasing collagen concentration in human dermal fibroblasts 13 and moderate binding ability to the rat uterine estrogen receptor.…”

mentioning

confidence: 99%

pH-Dependent Inclusion Complexation of Highly Succinylated Cyclosophoraoses with 4'-Hydroxyflavanone

Kwon¹,

Jung²

2011

Bulletin of the Korean Chemical Society

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“…Flavonoids which constitute an important part of human diet are associated with many beneficial biological activities, 2) though some may exhibit mutagenic and/or prooxidant properties. 3) They are known to interact with the cytochrome P450 drug-metabolizing enzymes found in liver and other tissues including skin.…”

mentioning

confidence: 99%

“…However, only a little hydroxylation occurred in B-ring. 8) 4Ј-Hydroxyflavanone, a synthetic analogue of flavanones is associated with biological activities including, endothelium-independent full vasorelaxing efficacy on rat aortic rings, 9) aromatase inhibitor properties, 10) decreasing collegen concentration in human dermal fibroblasts 11) and moderate binding ability to the rat uterine estrogen receptor. 12) Its metabolic transformation by rat liver microsomes resulted in the formation of 3Ј,4Ј-dihydroxyflavanone, 4Ј-hydroxyflavone, 6,4Ј-dihydroxyflavanone (tentative) and a chromone.…”

mentioning

confidence: 99%

Microbial Metabolism. Part 12.

Mikell

Herath

Khan

2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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Flavonoids which constitute an important part of human diet are associated with many beneficial biological activities, 2) though some may exhibit mutagenic and/or prooxidant properties.3) They are known to interact with the cytochrome P450 drug-metabolizing enzymes found in liver and other tissues including skin. The capability of flavonoids to induce biosynthesis of Cytochromes P450 (CYPs) and to modulate their activity could lead to loss of biological activity of a drug or to increase its concentration in the plasma resulting in an overdose.3) They may also activate or inhibit CYPs involved in the process of chemical carcinogenesis. It has been observed that Flavonoids with hydroxyl groups tend to inhibit these enzymes, whereas those without seem to stimulate them.4) The CYPs in turn can bring about transformation of flavonoids to metabolites which could interact with them and modify their activities. This underlines the importance of determining the metabolic pathways of flavonoids which are being consumed in measurable amounts by man. There are two major sites of flavonoid metabolism.3) They are the liver and the colon microflora. Several in vivo and in vitro experiments were conducted to identify the mammalian metabolites of different classes of flavonoids. Based on these observations various suggestions were made with regards to their metabolic pathways. The results of one such experiment involving the metabolism of 16 naturally occurring flavonoids by rat liver microsomes suggested that the B-ring was the main structural moiety that was subjected to biotransformation.5) The number and the position of the hydroxyl and methoxy groups in the B-ring seemed to determine the extent of metabolism. The non polar flavonoids were metabolized more extensively than the polar ones. The absence of hydroxyl groups in the B-ring or the presence of one such group at C-4Ј position resulted in 3Ј and 4Ј dihydroxylated (catechol) products. It was suggested that the semiquinones or quinones that could result from the oxidation of catechol may be a source of mutagenic free radicals. However, it has been demonstrated that partial detoxification takes place by O-methylation of the catechol moiety. 5,6) Flavanones, as compared to other flavonoids are less abundant in nature. Propolis, honey, citrus fruits and juices are their main dietary sources. 7) Flavanones are associated with many biological properties. The major constituent of citrus fruits, Naringenin for example was shown by in vitro experiments to have antioxidant, antiproliferative and estrogenic activities.7) Since citrus fruits and juices are consumed by man in considerable amounts, investigations have been carried out to evaluate their metabolic parthways. In a transformation study with six flavanones by rat liver microsomes the major metabolic pathway observed was aromatic hydroxylation. However, several previously unreported metabolic pathways including the reduction of the keto group were also discovered. 7) As many as 43 urinary metabolites of flavanone in the ra...

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Effect of Different Flavonoids on Collagen Synthesis in Human Fibroblasts

Cited by 61 publications

References 22 publications

Effect of Ethanolic Extract of Cyanotis Cristata Leaves Applied Topically on Wound Healing in Wistar Rats

Effect of Ethanolic Extract of Cyanotis Cristata Leaves Applied Topically on Wound Healing in Wistar Rats

pH-Dependent Inclusion Complexation of Highly Succinylated Cyclosophoraoses with 4'-Hydroxyflavanone

Microbial Metabolism. Part 12.

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