Effect of different factors on patient perception of surgical discomfort in third molar surgery

Reis, Giselle Emilãine da Silva; Calixto, Robson Diego; Petinati, Maria Fernanda Pivetta; Souza, Juliana Feltrin de; Küchler, Érika Calvano; Costa, Delson João da; Bonotto, Daniel; Rebellato, Nelson Luís Barbosa; Scariot, Rafaela

doi:10.1590/1807-3107bor-2021.vol35.0007

Cited by 6 publications

(3 citation statements)

References 36 publications

(64 reference statements)

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“…The product encoded by FKBP5 affects glucocorticoid receptor sensitivity and the biological effects of stress and anxiety [ 19 ]. Polymorphic variants in FKBP5 have been associated with a greater risk of depression [ 24 , 25 ], anxiety [ 25 ] and post-traumatic stress disorder [ 24 ] as well as greater surgical discomfort in third molar extractions [ 54 ]. Although we did not find an association between HTR2A and FKBP5 with anxiety, depression and chronic pain in this study, it is important to remember that we evaluated only two polymorphisms within the genes, so it is possible that there are associations in other polymorphisms in these genes with mental disorders.…”

Section: Discussionmentioning

confidence: 99%

Associations between Anxiety, Depression, Chronic Pain and Oral Health-Related Quality of Life, Happiness, and Polymorphisms in Adolescents’ Genes

Baldiotti

Amaral-Freitas

Barbosa

et al. 2023

IJERPH

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Adolescence is marked by changes and vulnerability to the emergence of psychological problems. This study aimed to investigate associations between anxiety/depression/chronic pain and oral health-related quality of life (OHRQoL)/happiness/polymorphisms in the COMT, HTR2A and FKBP5 genes in Brazilian adolescents. A cross-sectional study was conducted with ninety adolescents 13 to 18 years. Anxiety, depression and chronic pain were evaluated using the RDC/TMD. The Oral Health Impact Profile was used to assess oral OHRQoL. The Subjective Happiness Scale was used to assess happiness. Single-nucleotide polymorphisms in COMT (rs165656, rs174675), HTR2A (rs6313, rs4941573) and FKBP5 (rs1360780, rs3800373) were genotyped using the Taqman® method. Bivariate and multivariate logistic regression analyses were performed (p < 0.05). Chronic pain and depression were associated with feelings of happiness (p < 0.05). A significant inverse association was found between anxiety and OHRQoL (p = 0.004). The presence of minor allele C of COMT rs174675 was significantly associated with depression (p = 0.040). Brazilian adolescents with depression and chronic pain considers themselves to be less happy than others and those with anxiety are more likely to have a negative impact on OHRQoL. Moreover, the rs174675 variant allele in the COMT gene was associated with depressive symptoms in Brazilian adolescents.

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Section: Discussionmentioning

confidence: 99%

Associations between Anxiety, Depression, Chronic Pain and Oral Health-Related Quality of Life, Happiness, and Polymorphisms in Adolescents’ Genes

Baldiotti

Amaral-Freitas

Barbosa

et al. 2023

IJERPH

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“…In dentistry, some emerging studies have suggested that an individual's genetic background interferes with the perception of OHRQoL, providing evidence of the association between genetic polymorphisms and OHRQoL. [31][32][33][34][35] In individuals requiring orthognathic surgery, depression, temporomandibular disorders, and genetic polymorphisms in the IL6 gene negatively impact OHRQoL. 32 Polymorphisms in the ANKK1 gene are associated with a positive impact in women who undergo orthognathic surgery 31 .…”

Section: Discussionmentioning

confidence: 99%

“…32 Polymorphisms in the ANKK1 gene are associated with a positive impact in women who undergo orthognathic surgery 31 . Individuals carrying the AA genotype for rs3800373 in FKBP5 gene 34 reported more significant surgical discomfort associated with third molar surgery. Para-athletes who have experienced caries and possess the IL1A gene in a dominant model are significantly more likely to experience psychological discomfort than those with the alternate allele.…”

Section: Discussionmentioning

confidence: 99%

Association of MTR and MTRR genes and oral health-related quality of life in children with dental caries

et al. 2023

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This study aimed to assess whether genetic polymorphisms in MTR and MTRR are potential biomarkers of oral health-related quality of life (OHRQoL) in children with caries. A cross-sectional study was designed wherein pairs of parents/caregivers and children (aged two-five years) were selected. Clinical examination was used to detect dental caries, which were classified as low-severity and high-severity caries. The Early Childhood Oral Health Impact Scale (ECOHIS) questionnaire was used to assess OHRQoL. Genomic DNA extracted from the saliva was used to analyze two missense genetic polymorphisms: MTR (rs1805087) and MTRR (rs1801394). Mann-Whitney non-parametric test was used to analyze candidate genes with OHRQoL scale and domain, with a significance level of p≤0.05. MTR (rs1805087) was found associated (p = 0.05) with children's OHRQoL subscale scores in the dominant model (GG + AG). Genetic polymorphisms in MTR may increase the risk of poor OHRQoL in children with caries. Further studies are needed to investigate genetics, molecular factors, and OHRQoL.

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Efficacy of different dexamethasone routes and doses in reducing the postoperative sequelae of impacted mandibular third-molar extraction

Almadhoon¹,

Hamdallah²,

Eida³

et al. 2022

The Journal of the American Dental Association

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Effect of different factors on patient perception of surgical discomfort in third molar surgery

Cited by 6 publications

References 36 publications

Associations between Anxiety, Depression, Chronic Pain and Oral Health-Related Quality of Life, Happiness, and Polymorphisms in Adolescents’ Genes

Associations between Anxiety, Depression, Chronic Pain and Oral Health-Related Quality of Life, Happiness, and Polymorphisms in Adolescents’ Genes

Association of MTR and MTRR genes and oral health-related quality of life in children with dental caries

Efficacy of different dexamethasone routes and doses in reducing the postoperative sequelae of impacted mandibular third-molar extraction

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