1981
DOI: 10.1111/j.1600-0773.1981.tb00918.x
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Effect of Different Doses of D‐Penicillamine and Combined Administration of D‐Penicillamine and Methylprednisolone on Collagen, Glycosaminoglycans, DNA and RNA of Granulation Tissue, Skin, Bone and Aorta in Rats

Abstract: D‐penicillamine (D‐pen) in doses of 20, 100 and 500 mg/kg/day or D‐pen 100 mg/kg/day plus methylprednisolone (MP) 2.0 mg/kg/day was administered daily for 42 days to rats implanted with viscose‐cellulose sponges. Operated, pairfed rats served as controls. D‐pen increased the DNA content of granulation tissue, but had no effect on the amount of tissue produced. In contrast, high dose D‐pen reduced the content of DNA and collagen in skin. A dose related inhibition of collagen crosslink formation occurred in all … Show more

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Cited by 7 publications
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