Effect of different doses of furazolidone with amoxicillin and omeprazole on eradication of <i>Helicobacter pylori</i>

Roghani, H Salman; Massarrat, S.; Shirekhoda, Mohammad; Butorab, Zia

doi:10.1046/j.1440-1746.2003.03058.x

Cited by 36 publications

(36 citation statements)

References 36 publications

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“…In the present study, despite a comparable incidence of adverse effects during treatment, only three patients had severe symptoms demanding treatment discontinuation. Lower doses of furazolidone could decrease the incidence of undesirable symptoms, but this strategy can also lead to a lower eradication rate [22,28,29] . The prevalence of smokers was similar to that in the Brazilian population and no significant differences in the results were observed when analyzing the number of previous treatments, gender and age.…”

Section: Discussionmentioning

confidence: 99%

Quadruple therapy with furazolidone for retreatment in patients with peptic ulcer disease

Felga¹,

Silva²,

Barbuti³

et al. 2008

WJG

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AIM:To establish the efficacy and safety of a 7-d therapeutic regimen using omeprazole, bismuth subcitrate, furazolidone and amoxicillin in patients with peptic ulcer disease who had been previously treated with other therapeutic regimens without success. METHODS: Open cohort study which included patients with peptic ulcer who had previously been treated unsuccessfully with one or more eradication regimens. The therapeutic regimen consisted of 20 mg omeprazole, 240 mg colloidal bismuth subcitrate, 1000 mg amoxicillin, and 200 mg furazolidone, taken twice a day for 7 d. Patients were considered as eradicated when samples taken from the gastric antrum and corpus 12 wk after the end of treatment were negative for Helicobacter pylori (H pylori ) (rapid urease test and histology). Safety was determined by the presence of adverse effects. RESULTS: Fifty-one patients were enrolled. The eradication rate was 68.8% (31/45). Adverse effects were reported by 31.4% of the patients, and these were usually considered to be slight or moderate in the majority of the cases. Three patients had to withdraw from the treatment due to the presence of severe adverse effects. C O N C L U S I O N :T h e a s s o c i a t i o n o f b i s m u t h , furazolidone, amoxicillin and a proton-pump inhibitor is a valuable alternative for patients who failed to respond to other eradication regimens. It is an effective, cheap and safe option for salvage therapy of positive patients.

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Section: Discussionmentioning

confidence: 99%

Quadruple therapy with furazolidone for retreatment in patients with peptic ulcer disease

Felga¹,

Silva²,

Barbuti³

et al. 2008

WJG

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“…In that study, the low dose of furazolidone used was different from our study. Roghani et al (9) showed that furazolidone in combination with amoxicillin and omeprazole should be used as a higher dose. They concluded that, although serious adverse effects were less frequent with the lowdose regimen, the intention-to-treat eradication rate was not acceptable.…”

Section: Discussionmentioning

confidence: 99%

“…Furazolidone offer the advantage of low cost, but unfortunately, more adverse effects influence the drug efficacy (9,10). It should be considered that triple therapy with amoxicillin, furazolidone and omeprazole (AFO) is more tolerable due to fewer required drugs and is more economically affordable.…”

Section: Introductionmentioning

confidence: 99%

Furazolidone, amoxicillin and omeprazole with or without bismuth for eradication of Helicobacter pylori in peptic ulcer disease

Ghadir¹,

Shafaghi²,

Iranikhah³

et al. 2011

Turk J Gastroenterol

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“…Both protocols had ideal results with fewer side ef- fects [23,48] . Furazolidone has also been used in triple therapies in Iran [21,[80][81][82][83] . Five studies have investigated the effects of 4-, 7-and 14-d Furazolidone-containing triple therapies, but only a 7-d protocol, in which a probiotic had been added to the regimen, could achieve > 90% PP eradication rate [82] .…”

Section: Furazolidonementioning

confidence: 99%

“…Furazolidone has low cost and is readily available in developing countries. When it was administered in low doses (50 mg BD), the efficacy of regimen was shown to be very low [83] . On the other hand, when administered in high doses (200 mg BD), if tolerated, the efficacy of regimen was comparable to that of Clarithromycin-containing regimens [79] .…”

Section: Furazolidonementioning

confidence: 99%

Helicobacter pylorieradication in West Asia: A review

Fakheri

Bari

Aarabi

et al. 2014

WJG

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The efficacy of first-and second-line Helicobacter pylori (H. pylori ) eradication regimens varies considerably in West Asian countries, mainly due to the variable prevalence of resistant organisms. However, no review article has yet evaluated and compared the efficacy of different regimens among different countries of this region. Therefore, we conducted a review to select the best options and provide recommendations for H. pylori treatment in this geographic region. A search through PubMed was carried out to obtain relevant randomized clinical trials published in English language up to June 2013. According to the results, among different therapeutic regimens used as the first-line protocols, 10-d Bismuth-Furazolidone/Metronidazole quadruple therapy, 14-d Clarithromycin-containing hybrid therapy and 14-d quadruple therapy including a proton pump inhibitor + Bismuth + Tetracycline (500 mg QID) + Metronidazole (500 mg TDS) seemed to be appropriate options. Among second-line therapeutic regimens, Bismuthbased quadruple therapies containing Tetracycline and Furazolidone/Metronidazole, triple therapy containing Amoxicillin and Gatifloxacin and Quadruple therapy including Bismuth + Azithromycin and Ofloxacin seemed to be effective options. Third-line therapies were not evaluated in West Asia; most guidelines, however, recommend choosing optimal eradication regimen according to the pattern of antibiotic susceptibility of H. pylori . Although we limited our investigation to H. pylori eradication regimens in West Asia, the clinical significance of the results goes beyond the countries situated in this geographic region. In fact, the results are transferrable to any region as long as the patterns of resistance are the same. Core tip: The efficacy of first-and second-line Helicobacter pylori (H. pylori ) eradication regimens varies considerably in West Asian countries, mainly due to the variable prevalence of resistant organisms. The present study evaluates and compares the efficacy of different regimens among different countries of this region. Although we limited our investigation to H. pylori eradication regimens in West Asia, the clinical significance of the results goes beyond the countries situated in this geographic region. In fact, the results are transferrable to any region as long as the patterns of resistance are the same.

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Effect of different doses of furazolidone with amoxicillin and omeprazole on eradication of Helicobacter pylori

Abstract: The regimen with a non-reduced dose of furazolidone in combination with amoxycillin and omeprazole was effective when the patients tolerated the drugs and completed the study.

Cited by 36 publications

References 36 publications

Quadruple therapy with furazolidone for retreatment in patients with peptic ulcer disease

Quadruple therapy with furazolidone for retreatment in patients with peptic ulcer disease

Furazolidone, amoxicillin and omeprazole with or without bismuth for eradication of Helicobacter pylori in peptic ulcer disease

Helicobacter pylorieradication in West Asia: A review

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