Effect of Different Doses of Wheatgrass in Prevention of Carbon Tetrachloride Induced Hepatotoxicity in Rats

Kamboj, JK; Sv, Rana; Dhawan, D. K.; Vahiphei, K

doi:10.1016/s0973-6883(11)60081-9

Cited by 5 publications

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“…Maximum hepatoprotection in this study has been observed with 80mg/kg /day dose of wheatgrass tablets. This study indicated that wheatgrass treatment prevented the increase in liver enzymes depending on the dose of wheatgrass [28]. Decreased oxidative stress and increased antioxidant levels have also been observed with wheatgrass treatment [29].…”

Section: Hepatoprotective Role Of Wheatgrasssupporting

confidence: 52%

“…However, wheatgrass treatment to rats did not indicate any significant change in the activities of all above mentioned liver enzymes at the interval of 2 weeks. This study indicated that wheatgrass treatment prevented the increase in liver enzymes depending on the dose of wheatgrass [28]. 2) 18 Wistar rats with body weight of 120-150gms were divided into 3 groups.…”

Section: Wheatgrass and General Well Beingmentioning

confidence: 93%

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Living life the natural way – Wheatgrass and Health

Rana

Kamboj

Gandhi

2011

FFHD

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Abstract:The Human diet is enriched with young parts of plants (so called -green foods‖), which can improve nutrient balance intake in natural way. Wheatgrass (Triticum aestivum) refers to young grass of the common wheat plant, which belongs to Poaceae family. This is the most commonly found herb in India, although its nativity is currently unknown. This plant is believed to have many nutritional values; it has been shown to have anti-inflammatory, antioxidant, anticarcinogenic, immunomodulatory, laxative, astringent, diuretic, antibacterial and anti-aging properties. Its use in acidity, colitis, kidney malfunctions, atherosclerosis and swelling has been shown to be beneficial. Wheatgrass juice helps in building red blood cells and stimulates healthy tissue cell growth. 100 g of wheatgrass powder is equal to 23 kg of fresh vegetables. Ideally, wheatgrass should be taken about an hour prior to meal. This allows the body to fully metabolize it without competing with other foods, and it may also curb hunger. It is recommended that lot of water (at least a liter) should be consumed with the juice to reap its maximum nutritional benefits. Taking wheatgrass as a supplement in the mid-morning or mid-afternoon is a great time for this "green" energy boost.

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Section: Hepatoprotective Role Of Wheatgrasssupporting

confidence: 52%

Section: Wheatgrass and General Well Beingmentioning

confidence: 93%

Living life the natural way – Wheatgrass and Health

Rana

Kamboj

Gandhi

2011

FFHD

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“…With a dose of 100mg/kg/day, it showed a strong hepatoprotective impact in terms of ALP, SGPT, SGOT and Bilirubin in serum (Jain et al, 2007). Kamboj et al (2011a) reported that depending on the amount of wheat grass, it prevents a rise in liver enzymes.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of wheat and barley grasses on hepatotoxicity induced by tramadol in male rats

EL-Maoula

2019

African Journal of Biological Sciences

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Nowadays tramadol is becoming abused more popular among teens in most countries worldwide; especially between males. The aim of the present study was to investigate the protective effects of barley and wheat grasses on hepatotoxicity induced by tramadol in male rats. Thirty male albino rats weighing (150-200 g) were divided into two main groups: The first group (5 rats) was fed on basal diet and kept as a negative group (G-). The second group (25rats) was fed on basal diet and administrated tramadol (30mg/kg/day) orally for 30 days. After that, the rats were divided into five subgroups as following: Subgroup (1): kept as a positive group (G+). Subgroups (2&3) were given tramadol +wheat grass (250 and 500mg/kg body weight) and Subgroups (4&5) were given tramadol + barley grass (250 and 500mg/kg body weight) orally for 30 days. The biochemical data showed elevated liver enzymes; alanine transaminase (ALT), aspartate transaminase (AST), Alkaline Phosphatase (ALP), total bilirubin, direct bilirubin and in direct bilirubin as well as liver weight in tramadol group (G+). A significant increase in malondialdehyde (MDA) and nitric oxides (NO) were also noticed in (G+). While, there were a significant decrease in glutathione peroxidase (GPx), reduced glutathione (GSH) and catalase (CAT) levels in tramadol group (G+). Concomitant use of barley and wheat grass with tramadol induced improvement in the hepatotoxic effects. The best results were recorded for the groups treated with high dose (500mg/kg body weight) of barley and wheat grass. It was concluded from the present results that administration of barley and wheat grass with tramadol can ameliorating tramadol-induced hepatotoxicity which might be due to its antioxidant potential.

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“…The animals were anaesthetized using mild ether anesthesia so as to immobilize them during X-ray exposure. The group III animals were given wheatgrass extract at a dose of 80 mg/100 g bodyweight everyday orally for 2 weeks [26]. The group IV animals were given a combined treatment of whole-body X-ray exposure as well as wheatgrass with similar doses as were given to group II and group III, respectively.…”

Section: Animalsmentioning

confidence: 99%

In Vivo Radioprotective Effects of Wheatgrass (Triticum Aestivum) Extract Against X-Irradaition-Induced Oxidative Stress and Apoptosis in Peripheral Blood Lymphocytes in Rats

Shyam

Dhawan

Chadha

2018

Asian J Pharm Clin Res

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Objectives: The present study was undertaken to investigate the possible protective potential of wheatgrass extract against radiation-induced toxicity in peripheral lymphocytes of rats exposed to a fractionated dose of X-rays.Methods: Effects of the X-irradiation with and without wheatgrass were studied on various parameters in peripheral lymphocytes including antioxidant defense system and apoptosis. Male Sprague-Dawley rats were divided into four different groups: Normal control group, X-ray-irradiated group (21 Gy over a span of 7 days), wheatgrass-treated group (80 mg/100 g bodyweight for 2 weeks), and X-rays-irradiated + wheatgrass-treated group. All the biochemical indices which included lipid peroxidation (LPO), reduced glutathione, reactive oxygen species (ROS), and activities of antioxidant enzymes were investigated in lymphocytes. Terminal deoxynucleotidyl transferase dUTP nick-end labeling assay was carried out to assess the apoptosis in lymphocytes following whole-body X-irradiation.Results: Whole-body X-irradiation to rats resulted in significant increase in LPO with concomitant depression of antioxidant enzymes activities, namely, superoxide dismutase, catalase, and glutathione peroxidise (GPx) in lymphocytes. Further, the present study witnessed a significant increase in the number of apoptotic lymphocytes in the X-irradiated animals. However, wheatgrass supplementation lowered the LPO levels, restored cellular antioxidant status, and provided significant protection against radiation-induced apoptosis.Conclusions: Based on these observations, the present study suggests that wheatgrass extract has the potential to be used as an effective radioprotectant against radiation-induced oxidative stress and apoptosis in peripheral lymphocytes of whole-body X-ray-exposed rats.

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Effect of Different Doses of Wheatgrass in Prevention of Carbon Tetrachloride Induced Hepatotoxicity in Rats

Cited by 5 publications

References 0 publications

Living life the natural way – Wheatgrass and Health

Living life the natural way – Wheatgrass and Health

Protective effects of wheat and barley grasses on hepatotoxicity induced by tramadol in male rats

In Vivo Radioprotective Effects of Wheatgrass (Triticum Aestivum) Extract Against X-Irradaition-Induced Oxidative Stress and Apoptosis in Peripheral Blood Lymphocytes in Rats

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