Effect of different doses of the catecholamine epinephrine on antioxidant responses of larvae of the flesh fly Sarcophaga dux

Abdelfattah, Eman Alaaeldin; Renault, David

doi:10.1007/s11356-021-16325-9

Cited by 5 publications

(8 citation statements)

References 56 publications

(55 reference statements)

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“…These abnormal changes require organisms' adaptation and mitigation. These responses can be vital as they can allow the studying of specific defense mechanisms against various and different stress factors [2,5,7,8,14].…”

Section: Discussionmentioning

confidence: 99%

“…Exposure to environmental pollutants, including organic waste, chemical pollutants, and heavy metals, is linked with the elevated levels of oxidative stress through increasing the production of ROS; which cause deleterious effects on the macromolecules of the living organisms [2,3,5,7,8,14,65]. Besides that, heavy metals, especially Cu 2+ , can increase ROS production by disturbing the respiratory metabolism rate [74].…”

Section: Discussionmentioning

confidence: 99%

“…These oxidative stress parameters were evaluated, also, for control organic waste through assessment of the H 2 O 2 levels, macromolecules damaged products (protein carbonyls and lipid peroxides), as well as measuring the enzymatic and non-enzymatic antioxidants levels (SOD, CAT, GPx, DPPH or TAA), besides that the biomolecules concentration (proteins) and related detoxification enzymes in the KW or VW, 5 th instar larvae of BSF and larval excreta. These were done according to the generally accepted previous studies [7,65,97,98].…”

Section: Discussionmentioning

confidence: 99%

“…The proteins damage leads to conformation disruption of protein molecules, including enzymes [104,105]. Besides that, the significant elevation of lipid peroxides occurred when the antioxidants are depleted by the actions of ROS [5,7,8,96,106].…”

Section: Discussionmentioning

confidence: 99%

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Untitled

2022

JBR

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Environmental pollution sources including waste or metal accumulation, industrial and agricultural activities can be dangerous. Also, contaminated organic waste (COW) with metals especially, copper ions (Cu 2+ ), can cause toxicity to various ecosystem components, enhance the production of reactive oxygen species (ROS) and consequently cause oxidative stress. The biochemical effect of the COW was monitored by assessing the oxidative stress parameters (OSP) using hydrogen peroxides (H 2 O 2 ), protein carbonyls (PC), lipid peroxides (LP), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), 2,2 diphenyl-1-picrylhydrazyl (DPPH), total antioxidant ability (TAA); β-esterase (β-EST); and total amount of protein (TAP) levels on the organic waste (kitchen and vegetable wastes); Hermetia illucens larvae; and larval excreta collected from 7-day post-treated kitchen and vegetables wastes with (1:10; g:mL) distilled water (DW) or 100 mg/mL Cu 2+ . The OSP levels were significantly higher in the experimental samples from Cu 2+ groups than in the control one. Besides that, the OSP levels of H. illucens larvae feed on vegetable waste was significantly higher than those feed on kitchen waste except for β-EST, PC, and TPA. The best, cheap and easy parameters of antioxidants to ensure the entomoremediation ability are total antioxidant capacity. Possible impacts of accumulated and Cu 2+ contaminated organic waste on H. illucens larvae were discussed. Also, the ability of insects to produce more antioxidants than input or output sources was approved. The potential use of the OSP as a bioindicator method of the bioremediation ability of H. illucens was proposed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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2022

JBR

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“…The effects of various chemical or environmental pollutants on the insects' physiology and biochemistry have been investigated in various studies [1][2][3][4][5][6][7][8][9]. Environmental pollution sources including waste accumulation, industrial and agricultural activities have a direct effect on the amounts of cupper elevation than normal levels.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activities of Some Medicinal Plants on Common Multidrug-Resistant Bacterial Isolates from Some Patients Attending Federal Medical Center, Birnin Kebbi, Nigeria

Sani¹,

Jega²,

Danbare³

et al. 2022

JBR

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Bacterial infections are among the major causes of morbidity and mortality worldwide. The development of drug resistance to most antibiotics by bacterial species are pandemic, these necessitate the urgent need to search for new antibacterial drugs from the natural sources. Hence this research was aimed at evaluating the antibacterial activity of some medicinal plants on the most commonly drug resistant bacterial isolates from some patients attending Federal Medical Center (FMC) Birnin Kebbi, Nigeria. An ethno-botanical survey was carried out within Zuru Emirate and three (3) plant samples (Lonchocarpus laxiflorus root, Mitragyna inermis root and Lawsonia inermis root) were selected based on their number of citations and limited number of reported researches on the antibacterial activities of their roots. The multidrug resistant bacterial strains (Staplococcus aureus, Escherichia coli and Psuedomonas aeruginosa) obtained from FMC, Birnin Kebbi, were taken from nutrient agar slant and sub-cultured in nutrient agar plates. The antibacterial activities of the root methanol extracts of the plants were evaluated using agar-well diffusion method. Tube dilution method was used to determine the minimum inhibitory concentration of each plant extract. The preliminary phytochemical screening of the extracts was conducted using standard methods. Alkaloids, Flavaniods, Steriods, Tannins, saponnins and Phenols, were detected in L. laxiflorus root methanol extract, Flavaniods were absent in L. inermis and Alkaloids in M. inermis root methanol extracts. The plant extracts and their combinations showed varying degrees of antibacterial activities on the test isolates. The root methanol extracts of L. laxiflorus, L. inermis, L. laxiflorus/L. inermis, L. laxiflorus/M. inermis and L. inermis/M. inermis roots presented significant increase (p<0.05) in the zone of inhibition against S. aureus. Extracts of L. laxiflorus root, L. inermis root and combination of M. inermis root were able to suppress the growth of P. aeruginosa at lower dose of 25mg/ml. The antibacterial activity revealed that, the extracts exhibited dose dependent effect. L. inermis root had the highest activity and least MIC value of 12.5mg/ml against all the tested isolates. Thus, this research justified the use of these plants in traditional medicine for the treatment of bacterial infections and can also be considered as potential sources for development of new antibacterial agents that may be more effective, safe and readily accessible than the current antibiotics.

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Arylalkalamine N‐acetyltransferase‐1 acts on a secondary amine in the yellow fever mosquito, Aedes aegypti

et al. 2022

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Arylalkylamine N-acetyltransferase (aaNAT) in Aedes aegypti is primarily involved in cuticle pigmentation and formation. The reported arylalkylamine substrates are all primary amines. In this study, we report a novel substrate, a secondary amine, of Ae. aegypti aaNAT1. The recombinant aaNAT1 protein exhibited high activity to a secondary amine, epinephrine, which has not been reported for any aaNATs previously. Structure-activity relationship study demonstrated that aaNAT1 has an epinephrine-binding site, and molecular docking and dynamic simulation showed that epinephrine is quite stable in the active cavity. Further functional studies demonstrated that epinephrine affected mosquito fecundity, egg hatching and development. The new biochemical function of aaNAT1 in metabolizing epinephrine could reduce some negative effects of the compound in the mosquito.

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Effect of different doses of the catecholamine epinephrine on antioxidant responses of larvae of the flesh fly Sarcophaga dux

Cited by 5 publications

References 56 publications

Untitled

Untitled

Antibacterial Activities of Some Medicinal Plants on Common Multidrug-Resistant Bacterial Isolates from Some Patients Attending Federal Medical Center, Birnin Kebbi, Nigeria

Arylalkalamine N‐acetyltransferase‐1 acts on a secondary amine in the yellow fever mosquito, Aedes aegypti

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