Effect of different combinations of calcium, magnesium and phosphate on the inorganic composition of rat molars in vitro

Ameloot, Paul; Coomans, Danny; Smeyers‐Verbeke, J.; Boute, P

doi:10.1016/0003-9969(87)90036-7

Archives of Oral Biology

1987

DOI: 10.1016/0003-9969(87)90036-7

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Effect of different combinations of calcium, magnesium and phosphate on the inorganic composition of rat molars in vitro

Paul Ameloot

Danny Coomans

J. Smeyers‐Verbeke

et al.

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Cited by 3 publications

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“…Such clearance may allow the fluorotic matrix to mineralize. We examined this by loading the enamel with extra mineral, prior to exposure to F, by preculturing tooth explants in calcium‐enriched media (18,19). Then, explants were transferred to media containing standard calcium levels and exposed to a fluorotic dose of F. If the hypothesis holds true, we expect that a higher mineral content in the pre‐exposure enamel would rapidly bind F and prevent the formation of fluorotic enamel.…”

mentioning

confidence: 99%

Effect of calcium, given before or after a fluoride insult, on hamster secretory amelogenesis in vitro

Bronckers

Bervoets

Wöltgens

et al. 2006

European J Oral Sciences

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We tested the hypothesis that high-calcium medium given prior to or immediately after exposure to fluoride (F) reduces the negative effects of F on secretory amelogenesis. Hamster molar tooth germs were grown in organ culture in media with different calcium levels. Deposition of enamel matrix and matrix mineralization were monitored by incorporation of [3H]proline and uptake of 45Ca and acid-soluble 32PO4. Ameloblast structure and the occurrence of a fluorotic enamel matrix were examined by light and electron microscopy. A preculture of explants in high-calcium medium partially prevented the formation of fluorotic (non-mineralizing) enamel matrix, increased matrix secretion but could not prevent F-induced hypermineralization of the pre-exposure enamel. High-calcium medium, applied after F insult, accelerated the recovery of fluorotic matrix, improved ameloblast structure, enhanced amelogenin secretion, and increased enamel thickness. The data indicate that it might be the balance between the amount of mineral deposition and that of matrix secretion which is critical for the mineralization of newly secreted enamel. Exposure to F disturbs this balance by enhancing mineralization of the pre-exposure enamel, probably generating an excess of protons. High calcium may protect against F exposure by enhancing amelogenin secretion into the enamel space, thereby increasing the local buffering capacity at the mineralization front.

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mentioning

confidence: 99%

Effect of calcium, given before or after a fluoride insult, on hamster secretory amelogenesis in vitro

Bronckers

Bervoets

Wöltgens

et al. 2006

European J Oral Sciences

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show abstract

Antagonism of fluoride toxicity by high levels of calcium but not of inorganic phosphate during secretory amelogenesis in the hamster tooth germ in vitro

Bronckers

Bervoets

Lyaruu

et al. 1989

Archives of Oral Biology

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In vitro effect of chlorpromazine on the mineralization of tooth germ in mice. Comparison with that of retinoic acid and HEBP.

Kondo

1991

Folia Pharmacologica Japonica

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Effect of different combinations of calcium, magnesium and phosphate on the inorganic composition of rat molars in vitro

Cited by 3 publications

References 20 publications

Effect of calcium, given before or after a fluoride insult, on hamster secretory amelogenesis in vitro

Effect of calcium, given before or after a fluoride insult, on hamster secretory amelogenesis in vitro

Antagonism of fluoride toxicity by high levels of calcium but not of inorganic phosphate during secretory amelogenesis in the hamster tooth germ in vitro

In vitro effect of chlorpromazine on the mineralization of tooth germ in mice. Comparison with that of retinoic acid and HEBP.

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