2011
DOI: 10.1186/cc9516
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Effect of different antioxidants in ischemia-reperfusion syndrome

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“…The oxygen and nutrient deprivation from infarction site brings about a series of biochemical and metabolic changes within the myocardium such as relative absence of oxygen (leading to mitochondrial dysfunction), loss of membrane potential and cellular apoptosis or necrosis. Use of pharmacological modulators of reperfusion injury such as ascorbic acid, vitamin E, selenium, taurine, and tocopherol is previously reported to offer mild to moderate cardioprotection but exhibits limitations such as rapid utilization and clearance which results in limited activity.…”
Section: Introductionmentioning
confidence: 99%
“…The oxygen and nutrient deprivation from infarction site brings about a series of biochemical and metabolic changes within the myocardium such as relative absence of oxygen (leading to mitochondrial dysfunction), loss of membrane potential and cellular apoptosis or necrosis. Use of pharmacological modulators of reperfusion injury such as ascorbic acid, vitamin E, selenium, taurine, and tocopherol is previously reported to offer mild to moderate cardioprotection but exhibits limitations such as rapid utilization and clearance which results in limited activity.…”
Section: Introductionmentioning
confidence: 99%