Effect of different anaesthetic techniques on gene expression profiles in patients who underwent hip arthroplasty

Alleva, Renata; Tognú, Andrea; Tomasetti, Marco; Benassi, Maria Serena; Pazzaglia, Laura; Oven, Hanna van; Viganò, E; Simone, Nicola de; Pacini, Ilaria; Giannone, Sandra; Gagic, Sanjin; Borghi, Raffaele; Picone, S.; Borghi, Battista

doi:10.1371/journal.pone.0219113

Cited by 4 publications

(5 citation statements)

References 34 publications

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“…ORTHOTEP University HS Carl Gustav Carus [ 109 , 619 ] 2. Dresden Hip Surgery Registry [ 52 , 196 ] Heidelberg University of Heidelberg [ 410 ] Regensburg Regensburg University [ 198 , 255 , 292 , 296 , 299 ] Greece Athens General HS KAT [ 155 , 384 , 646 ] Thessaloniki Arthroplasty RG Thessaloniki (ART) [ 2 , 12 , 406 , 455 , 647 ] Italy Emilia-Romanga Register of Orthopaedic Prosthetic Implant (RIPO) [ 24 , 26 , 39 , 43 , 57 , 145 , 164 , 189 , 231 , 288 , 297 , 468 , 476 , 482 , 491 , 502 , 506 , 508 , 527 , 540 , 562 , 563 , 569 , 585 , 592 , 597 , …”

Section: Resultsmentioning

confidence: 99%

“…The “Register of Orthopaedic Prosthetic Implant (RIPO) of Emilia-Romagna region” published 30 papers from 2002 to 2022 [ 24 , 645 ]. Among them, twenty-eight were cohort studies [ 24 , 26 , 39 , 43 , 57 , 145 , 164 , 189 , 231 , 288 , 297 , 482 , 491 , 502 , 506 , 508 , 527 , 540 , 562 , 563 , 569 , 585 , 592 , 597 , 599 , 624 , 630 , 645 ], one was RCT [ 476 ] and one registry protocol [ 468 ]. Of these 30 studies, 16 were survival [ 26 , 164 , 189 , 231 , 288 , 482 , 491 , 502 , 508 , 527 , 540 , 563 , 569 , 585 , 592 , 599 ], six analysed implant types [ 24 , 43 , 297 , 506 , 624 , 645 ], and two studied postoperative complications [ 597 , 630 ].…”

Section: Resultsmentioning

confidence: 99%

“…Of these 30 studies, 16 were survival [ 26 , 164 , 189 , 231 , 288 , 482 , 491 , 502 , 508 , 527 , 540 , 563 , 569 , 585 , 592 , 599 ], six analysed implant types [ 24 , 43 , 297 , 506 , 624 , 645 ], and two studied postoperative complications [ 597 , 630 ]. Long-term postoperative outcomes [ 562 ], cost [ 57 ] and risk factors analysis [ 39 ], genetic studies [ 476 ], a protocol for registry study [ 468 ] and comparison of different surgical techniques [ 145 ] were among the primary outcomes of other study types.…”

Section: Resultsmentioning

confidence: 99%

“…Level II–IV JARs often report studies that analyze risk factors (obesity/rheumatic diseases) of TJA outcomes, but also cost analysis studies of the length of hospital stay following TJA improving the cost-effectiveness of joint replacements [ 76 , 158 , 333 , 425 , 456 , 486 ]. Genetic studies have also been performed [ 350 , 476 ].…”

Section: Discussionmentioning

confidence: 99%

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Global mapping of institutional and hospital-based (Level II–IV) arthroplasty registries: a scoping review

Zgouridou,

Kenanidis,

Potoupnis

et al. 2023

Eur J Orthop Surg Traumatol

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Purpose Four joint arthroplasty registries (JARs) levels exist based on the recorded data type. Level I JARs are national registries that record primary data. Hospital or institutional JARs (Level II–IV) document further data (patient-reported outcomes, demographic, radiographic). A worldwide list of Level II–IV JARs must be created to effectively assess and categorize these data. Methods Our study is a systematic scoping review that followed the PRISMA guidelines and included 648 studies. Based on their publications, the study aimed to map the existing Level II–IV JARs worldwide. The secondary aim was to record their lifetime, publications’ number and frequency and recognise differences with national JARs. Results One hundred five Level II–IV JARs were identified. Forty-eight hospital-based, 45 institutional, and 12 regional JARs. Fifty JARs were found in America, 39 in Europe, nine in Asia, six in Oceania and one in Africa. They have published 485 cohorts, 91 case-series, 49 case–control, nine cross-sectional studies, eight registry protocols and six randomized trials. Most cohort studies were retrospective. Twenty-three per cent of papers studied patient-reported outcomes, 21.45% surgical complications, 13.73% postoperative clinical and 5.25% radiographic outcomes, and 11.88% were survival analyses. Forty-four JARs have published only one paper. Level I JARs primarily publish implant revision risk annual reports, while Level IV JARs collect comprehensive data to conduct retrospective cohort studies. Conclusions This is the first study mapping all Level II–IV JARs worldwide. Most JARs are found in Europe and America, reporting on retrospective cohorts, but only a few report on studies systematically.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Global mapping of institutional and hospital-based (Level II–IV) arthroplasty registries: a scoping review

Zgouridou,

Kenanidis,

Potoupnis

et al. 2023

Eur J Orthop Surg Traumatol

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“…Of concern is that 11 genes are upregulated both in postmortem brains and induced coma: Cdc42 , Csnk2a1 , Gadd45a , Prdx2 , Rasa1 , Tnfrsf14 , Tpr , Klkb1 , Bcl2 , Ier3 , and Zfand2a [ 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 ]. Further, near-death experiences and induced coma that is required in numerous conditions associated with cardiopulmonary arrest with multiple organ failure, are always accompanied by a loss of consciousness [ 119 , 120 , 121 , 122 , 123 , 124 ].…”

Section: Discussionmentioning

confidence: 99%

Induced Coma, Death, and Organ Transplantation: A Physiologic, Genetic, and Theological Perspective

Coliță

Olaru

Coliță

et al. 2023

IJMS

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In the clinic, the death certificate is issued if brain electrical activity is no longer detectable. However, recent research has shown that in model organisms and humans, gene activity continues for at least 96 h postmortem. The discovery that many genes are still working up to 48 h after death questions our definition of death and has implications for organ transplants and forensics. If genes can be active up to 48 h after death, is the person technically still alive at that point? We discovered a very interesting parallel between genes that were upregulated in the brain after death and genes upregulated in the brains that were subjected to medically-induced coma, including transcripts involved in neurotransmission, proteasomal degradation, apoptosis, inflammation, and most interestingly, cancer. Since these genes are involved in cellular proliferation, their activation after death could represent the cellular reaction to escape mortality and raises the question of organ viability and genetics used for transplantation after death. One factor limiting the organ availability for transplantation is religious belief. However, more recently, organ donation for the benefit of humans in need has been seen as “posthumous giving of organs and tissues can be a manifestation of love spreading also to the other side of death”.

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Protecting the injured central nervous system: Do anesthesia or hypothermia ameliorate secondary injury?

Davis

Grau

2023

Experimental Neurology

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Effect of different anaesthetic techniques on gene expression profiles in patients who underwent hip arthroplasty

Cited by 4 publications

References 34 publications

Global mapping of institutional and hospital-based (Level II–IV) arthroplasty registries: a scoping review

Global mapping of institutional and hospital-based (Level II–IV) arthroplasty registries: a scoping review

Induced Coma, Death, and Organ Transplantation: A Physiologic, Genetic, and Theological Perspective

Protecting the injured central nervous system: Do anesthesia or hypothermia ameliorate secondary injury?

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