Effect of dieting on plasma leptin, soluble leptin receptor, adiponectin and resistin levels in healthy volunteers

Wolfe, Barbara E.; Jimerson, David C.; Orlova, Christine; Mantzoros, Christos S.

doi:10.1111/j.1365-2265.2004.02101.x

Cited by 134 publications

(109 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In NGT subjects, adiponectinemia was slightly decreased with no change in insulin sensitivity. Although unexpected, this is in agreement with a recent study that reported a reduced adiponectinemia in healthy volunteers during a 4-week VLCD (11). It is interesting to note that, at the metabolic level, the NGT subjects were very close to non-obese subjects studied by Wolfe and colleagues (11).…”

Section: Discussionsupporting

confidence: 77%

“…Although unexpected, this is in agreement with a recent study that reported a reduced adiponectinemia in healthy volunteers during a 4-week VLCD (11). It is interesting to note that, at the metabolic level, the NGT subjects were very close to non-obese subjects studied by Wolfe and colleagues (11). Therefore, as previously suggested, it can be hypothesized that the predominant loss of S.C. instead of visceral adipose tissue could explain the decrease in adiponectin level.…”

Section: Discussionsupporting

confidence: 76%

See 1 more Smart Citation

Increased adiponectin receptor-1 expression in adipose tissue of impaired glucose-tolerant obese subjects during weight loss

Kim

Maachi²,

Debard³

et al. 2006

eur j endocrinol

View full text Add to dashboard Cite

Objective: To investigate the mRNA expression of adiponectin, AdipoR1 and AdipoR2, the two recently cloned adiponectin receptors and peroxisome proliferator activated receptor (PPAR)g2 in adipose tissue of obese individuals before and during a very low calorie diet (VLCD) inducing weight loss. Methods: Twenty-three non-diabetic obese subjects with normal (NGT, nZ11) or impaired glucose tolerance (IGT, nZ12) (age, 47G3 years; body mass index, 39.3G1.3 kg/m 2 ) were studied before and after a 3-week 3.9 MJ diet daily without exercise. mRNA levels of nine IGT and six NGT subjects were measured by real-time PCR in S.C. abdominal adipose tissue. Results: Metabolic parameters and insulin sensitivity were improved by VLCD in the IGT group, but minimally affected in the NGT group. VLCD increased expression of AdipoR1 in the IGT (PZ0.02), but not in the NGT group. Adiponectin, AdipoR2 and PPARg2 mRNA levels did not change during VLCD in any group. In the IGT, but not in the NGT group, AdipoR1 and AdipoR2 expressions were positively related to that of PPARg2 and, after VLCD, AdipoR1 and AdipoR2 expressions were positively related to each other and to that of adiponectin. Conclusion: In the NGT group, the 3-week VLCD inducing weight loss did not modify metabolic parameters, insulin sensitivity and the expression of the adiponectin system in adipose tissue. By contrast, in the IGT group, AdipoR1 expression increased and we found a coordinate regulation of the expression of adiponectin and its receptors. These modifications could participate, through adiponectin action on adipocytes, to the improved metabolic parameters observed in IGT subjects. European Journal of Endocrinology 155 161-165

show abstract

Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 76%

Increased adiponectin receptor-1 expression in adipose tissue of impaired glucose-tolerant obese subjects during weight loss

Kim

Maachi²,

Debard³

et al. 2006

eur j endocrinol

View full text Add to dashboard Cite

show abstract

“…Some investigators observed a decrease in serum resistin during weight loss 5,10 or an increase during weight gain, 32 while others reported no changes in serum resistin. 33,34 In the present study, serum resistin was positively correlated to serum fructosamines and HOMA-SI. Nevertheless, favorable changes in markers of glucose metabolism and insulin resistance during weight loss were not related to changes in serum resistin during the intervention.…”

Section: Discussionsupporting

confidence: 56%

Increase in serum resistin during weight loss in overweight subjects is related to lipid metabolism

et al. 2006

View full text Add to dashboard Cite

Objective: Human resistin has been stated to influence preadipocyte cell numbers and to stimulate adipocyte triglyceride lipolysis in vivo and in vitro. However, its role in human obesity remains unclear. Design: Cross-sectional study for comparisons of lean and obese subjects, and subsequent longitudinal 4-month weight loss intervention study in obese subjects. Subjects: Healthy subjects, lean (n ¼ 20, BMIo25) and overweight (n ¼ 43, BMIX25). Measurements: Serum resistin, body weight, body fat, waist-to-hip ratio, as well as markers of insulin resistance and lipid metabolism at baseline and after 4 months of intervention. Results: Serum resistin was positively correlated to HOMA-IR (partial r ¼ 0.288; P ¼ 0.055), serum fructosamines (partial r ¼ 0.280; P ¼ 0.062), serum NEFA (partial r ¼ 0.276; P ¼ 0.066) and negatively to age (partial r ¼ À0.349; P ¼ 0.019) and serum apolipoprotein A-1 (partial r ¼ À0.363; P ¼ 0.014). During the intervention, serum resistin increased significantly (Po0.001). The increase was inversely related to changes in waist-to-hip ratio (P ¼ 0.025) and positively to serum apolipoprotein B (P ¼ 0.011). In males only, the increase in resistin during weight loss was predicted by total serum cholesterol at baseline (r ¼ 0.703, P ¼ 0.007). No relation was observed between changes in resistin and changes in HOMA-IR. Conclusion: The present study indicates an association between serum resistin and markers of abdominal fat distribution as well as the regulation of lipid metabolism. However, human resistin is unlikely to play an independent role in the regulation of glucose metabolism.

show abstract

“…Therefore, the effect of exercise on adiponectin levels in obesity may be different between male and female subjects. Adiponectin levels have been reported to be inversely correlated with central adipose tissue stores [34,35] and positively correlated with subcutaneous adipose tissue [36]. Thus, it is possible that loss of visceral fat has resulted in increased adiponectin levels concomitante with body weight reduction in obese young women in the present study.…”

Section: Discussionmentioning

confidence: 50%

Effect of Exercise on Circulating Adipokine Levels in Obese Young Women

2006

View full text Add to dashboard Cite

Abstract. We studied the effect of exercise on circulating adipokine, high sensitivity C-reactive protein (hs-CRP), and metabolic parameters in obese young women. Ninety-six healthy Japanese young female students aged 18-23 years were studied. The longitudinal intervention study of a 7-month exercise training program (30-60 min/day, 60-70% HRreserve, 200-400 kcal, 4-5 days/week) was performed in eight obese female students (BMI ³25 kg/m 2 ). Eight control female students (mean BMI = 22 kg/m 2 ) were included in the follow-up study. Body weight, body mass index (BMI), percentage of body fat (%Fat), body fat mass, lean body mass, health-promoting lifestyle profile-scale (L-scale), Vo 2 max (maximal oxygen uptake), hs-CRP, lipids, insulin homeostasis model assessment (HOMA-R), fasting levels for circulating adiponectin, leptin, and TNF-a, were measured before and after the exercise program. In obese subjects, body weight, BMI, %Fat, body fat mass, lean body mass, hs-CRP, leptin, and TNF-a were significantly higher, and L-scale and adiponectin were lower than those in control subjects. In obese subjects, exercise decreased body weight, BMI, %Fat, body fat mass, lean body mass, hs-CRP, leptin, and TNF-a, and increased L-scale, Vo 2 max, HDL-cho, and adiponectin. It was concluded that changes in circulating adipokine levels are involved in the improvement of the metabolic state by exercise and may be useful markers for evaluation and prescription of exercise.

show abstract

Effect of dieting on plasma leptin, soluble leptin receptor, adiponectin and resistin levels in healthy volunteers

Cited by 134 publications

References 50 publications

Increased adiponectin receptor-1 expression in adipose tissue of impaired glucose-tolerant obese subjects during weight loss

Increased adiponectin receptor-1 expression in adipose tissue of impaired glucose-tolerant obese subjects during weight loss

Increase in serum resistin during weight loss in overweight subjects is related to lipid metabolism

Effect of Exercise on Circulating Adipokine Levels in Obese Young Women

Contact Info

Product

Resources

About