Effect of dietary vitamin E on lipofuscin accumulation with age in the rat brain

Monji, Akira; Morimoto, Nobumitsu; Okuyama, Iwao; Yamashita, Norifumi; Tashiro, Nobutada

doi:10.1016/0006-8993(94)90258-5

Cited by 33 publications

(12 citation statements)

References 19 publications

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“…The increase in LP with age in many tissues has been reported to occur concomitantly with increased DNA and protein oxidation, and mitochondrial OS in animal as well as human models [2,27,31]. Our results on statistically insignificant effect of either Vitamin E or exercise training on the accumulation of LF-like AFS in the CC as well as HC in the old is in accordance with that reported by Monji et al [23] for certain regions like HC and cerebellum A notable feature was that unsupplemented sedentary of 4, 8 and 12 mos of age showed significantly higher MDA and LF-like AFS in the CC than in the HC and this trend was not seen in the old. LF-like AFS is known to occur significantly in aging tissues such as the heart and brain which contain lipid aldehydes that react with amines to synthesize LF-like substances [8].…”

Section: Discussionsupporting

confidence: 93%

Regional responses in antioxidant system to exercise training and dietary Vitamin E in aging rat brain

Devi

Kiran

2004

Neurobiology of Aging

130

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We have evaluated the effect of exercise, Vitamin E and a combination of both on the antioxidant enzymes (AOEs)-superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) along with the products of lipid peroxidation (LP)-malondialdehyde (MDA) and lipofuscin-like auto fluorescent substances (LF-like AFS) in discrete brain regions of rats of 4 (young adults), 8 (old adults), 12 (middle-age) and 22 months (mos) old of age. Hippocampus (HC) showed greater increase in GSH-Px activity than cerebral cortex (CC) to exercise and Vitamin E and was irrespective of the age. A combination of both was effective in the CC of all age groups but not in the supplemented sedentary of 12-and 22-mo-olds. CAT activity increased significantly in the HC of supplemented and trained rats but not in the combination group of any age. SOD increased in both the regions of supplemented trainees. However, old were more benefited in terms of maximal elevation in the HC. Vitamin E reduced MDA content in both regions of adult. LF-like AFS decreased significantly in supplemented sedentary and trainees of all ages. Our results demonstrate that an age-related deficit in AOEs in the CC and HC can be overcome through Vitamin E plus exercise, and further suggests the rationale for looking at these markers of oxidative stress in several age-related neuronal diseases.

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Section: Discussionsupporting

confidence: 93%

Regional responses in antioxidant system to exercise training and dietary Vitamin E in aging rat brain

Devi

Kiran

2004

Neurobiology of Aging

130

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“…In humans, some of the symptoms of vitamin E deficiency, such as increased lipofuscinosis most likely originate from the lack of scavenging ROS in the lipid phase (Monji et al, 1994;Porta, 2002), whereas others symptoms such as the dying-back sensory axonopathy may also be explainable by other ways, e.g. by modulating gene expression in the brain (Ezaki et al, 2005;Hyland et al, 2006;Rota et al, 2005;Roy et al, 2002;Stolzing et al, 2006) and by acting as a survival factor for specific neuronal cells (Cecchini et al, 2003;Copp et al, 1999;Cuppini et al, 2002;Nakajima et al, 1991;Yokota et al, 2000).…”

Section: Research On Cellular Effects Of Vitamin Ementioning

confidence: 99%

Vitamin E: An overview of major research directions

Zingg

2007

Molecular Aspects of Medicine

179

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“…Lipofuscin LF, a byproduct of reactions between carbonyls and aldehydes resulting from LPO reactions, was measured in erythrocytes (Monji et al 1994). The samples were examined under a fluorescence microscope (Olympus IX 70).…”

Section: Lipid Peroxidationmentioning

confidence: 99%

Oxidative stress in erythrocytes: a study on the effect of antioxidant mixtures during intermittent exposures to high altitude

2010

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The aim of our study was to compare and assess the effectiveness of antioxidant mixtures on the erythrocytes (RBC) of adult male albino rats (Wister) subjected to simulated intermittent high altitudes--5,100 m (AL(1)) and 6,700 m (AL(2))--to induce oxidative stress (OS). To achieve our objective, we pre-supplemented four sets of animals with different antioxidant mixtures [vitamin E (vit.E; 50 IU/kg BW), vitamin C (vit.C; 400 mg/kg) and L: -carnitine (400 mg/kg)] in different combinations [M1 (vit.E+vit.C), M2 (vit.C+carnitine), M3 (vit.E+carnitine) and M4 (vit.C+vit.E+carnitine)] for 30 days prior to as well during exposure to intermittent hypobaric hypoxia (IHH). Membrane instability, in terms of osmotic fragility and hemolysis, decreased in RBCs of supplemented animals. There was a significant increase in the activity of glutathione peroxidase in the RBCs of supplemented animals. We confirmed OS imposed by IHH with assays relating to lipid [thiobarbituric acid reactive substances (TBARS) and lipofuscin (LF)] and protein (carbonyl, PrC) oxidation, and found a positive correlation between PrC and hemolysis, with a decrease in both upon supplementation with M3 and M4 mixtures. Fluorescence microscopic observation showed a maximum decrease in the LF content in rats administered M4 and M1 compared to those on M2 and M3 mixtures at both altitudes. We suggest that multiple antioxidant fortifications are effective in overcoming increased OS experienced by RBCs at high altitudes.

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Effect of dietary vitamin E on lipofuscin accumulation with age in the rat brain

Cited by 33 publications

References 19 publications

Regional responses in antioxidant system to exercise training and dietary Vitamin E in aging rat brain

Regional responses in antioxidant system to exercise training and dietary Vitamin E in aging rat brain

Vitamin E: An overview of major research directions

Oxidative stress in erythrocytes: a study on the effect of antioxidant mixtures during intermittent exposures to high altitude

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