Effect of dietary virgin olive oil on urinary excretion of etheno–DNA adducts

Hillestrøm, Peter René; Covas, Marı́a-Isabel; Poulsen, Henrik E.

doi:10.1016/j.freeradbiomed.2006.06.013

Cited by 41 publications

(25 citation statements)

References 25 publications

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“…The intake of x6-PUFA has been associated with an increase of etheno-DNA adducts in urine [99] and in white cells [100] in female subjects. In contrast, consumption of 25 mL/day of VOO during 3 weeks did not modify the urinary excretion of etheno-DNA adducts in healthy volunteers [101]. In the study referred to [101], the dietary intake of linoleic acid was the highest predictor (45%) of the urinary edA excretion and, together with the dietary iron intake, predicted a 46% of the urinary edC excretion.…”

Section: Dna Oxidative Damagementioning

confidence: 70%

Olive oil and oxidative stress

Fitó¹,

Torre²,

Covas³

2007

Molecular Nutrition Food Res

121

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Oxidative stress is defined as an imbalance between the oxidant and antioxidant systems of the body, in favor of the oxidants. Oxidative stress produced by free radicals has been linked to the development of several diseases such as cardiovascular, cancer, and neurodegenerative diseases Olive oil is the main source of fat of the Mediterranean diet which has been shown to be effective against oxidative stress associated diseases and also with ageing. Besides its richness in monounsaturated fatty acids, the oleic acid, olive oil contains minor components with antioxidant properties. In this review, we summarize the state of the art, and degree of evidence, of the body of knowledge concerning the protective role of the major and minor components of olive oil on oxidative stress.

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Section: Dna Oxidative Damagementioning

confidence: 70%

Olive oil and oxidative stress

Fitó¹,

Torre²,

Covas³

2007

Molecular Nutrition Food Res

121

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“…For example, in Japanese women, urinary qdA levels were positively associated with increased N-6 polyunsaturated fatty acid intake and NaCl excretion, providing evidence of salt-induced inflammation and lipid peroxidation (51). It has also been reported that short-term fasting does not affect urinary qdA adduct or, indeed, 8-oxodG levels in healthy Korean women despite a reduction in primary lipid peroxidation products (e.g., urinary MDA and 8-isoprostaglandin (57) and have been applied to show a significant association between etheno-DNA adduct excretion rate and the dietary intake of linoleic acid in healthy men (58). A 32 P postlabeling method has also been reported, which measures 3,N 4 -ethenodeoxycytidine in human urine (59).…”

Section: Methods Of Analysismentioning

confidence: 99%

Measurement and Meaning of Oxidatively Modified DNA Lesions in Urine

Cooke

Oliński²,

Loft³

2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

205

147

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Background: Oxidatively generated damage to DNA has been implicated in the pathogenesis of a wide variety of diseases. The noninvasive assessment of such damage, i.e., in urine, and application to large-scale human studies are vital to understanding this role and devising intervention strategies. Methods: We have reviewed the literature to establish the status quo with regard to the methods and meaning of measuring DNA oxidation products in urine. Results: Most of the literature focus upon 8-oxo-7,8-dihydro-2 ¶-deoxyguanosine (8-oxodG), and whereas a large number of these reports concern clinical conditions, there remains (a) lack of consensus between methods, (b) possible contribution from diet and/or cell death, (c) no definitive DNA repair source of urinary 2 ¶-deoxyribonucleoside lesions, and (d) no reference ranges for healthy or diseased individuals. Conclusions: The origin of 8-oxodG is not identified; however, recent cell culture studies suggest that the

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“…Antioxidant compounds supplied in the diet can reduce the risk of cancer due to the fact that they can minimize DNA damage, lipid peroxidation and the amount of ROS generated (Omar, 2010a;Hillestrom, 2006;Manna, 2005).…”

Section: Anticancer Activitymentioning

confidence: 99%