Effect of Dietary Supplementation with Omega-3 Fatty Acid and Gamma-linolenic Acid on Acne Vulgaris: A Randomised, Double-blind, Controlled Trial

Jung, Ji Ye; Kwon, Hyuck Hoon; Hong, John; Yoon, Ji Young; Park, Mi Sun; Jang, Mi; Suh, Dae Hun

doi:10.2340/00015555-1802

Cited by 83 publications

(79 citation statements)

References 56 publications

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“…have demonstrated that chocolate consumption primes human blood mononuclear cells from volunteers to release more IL‐1β and IL‐10 upon stimulation with P. acnes , potentially revealing underlying mechanisms for acne aggravation. We also reported that omega‐3 fatty acids and γ‐linolenic acid could improve acne during a 10‐week clinical trial . At final visits (after 10 weeks of intervention), the mean inflammatory acne lesion count was significantly reduced in the omega‐3 group from 10·1 ± 3·2 to 5·8 ± 3·4.…”

Section: Recent Findingsmentioning

confidence: 72%

“…Finally, several factors, including diet and genetic factors, have been largely neglected in acne physiopathology research. However, recent well‐designed clinical studies have demonstrated causal relationships between acne and nutrition, and researchers have provided constructive views to support this relationship at the molecular level . It is to be hoped that recent genome‐wide linkage and association studies might reveal hidden culprit genes involved in acne physiopathology that might explain a hereditary susceptibility to acne and acne scarring .…”

Section: Outlook and Future Perspectivesmentioning

confidence: 99%

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What's new in the physiopathology of acne?

2015

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SummaryThere are four central factors that contribute to acne physiopathology: the inflammatory response, colonization with Propionibacterium acnes, increased sebum production and hypercornification of the pilosebaceous duct. In addition, research in the areas of diet and nutrition, genetics and oxidative stress is also yielding some interesting insights into the development of acne. In this paper we review some of the most recent research and novel concepts revealed in this work, which has been published by researchers from diverse academic disciplines including dermatology, immunology, microbiology and endocrinology. We discuss the implications of their findings (particularly in terms of opportunities to develop new therapies), highlight interrelationships between these novel factors that could contribute to the pathology of acne, and indicate where gaps in our understanding still exist.Acne vulgaris is a near universal cutaneous inflammatory disease affecting more than 85% of adolescents worldwide. 1,2While not a fatal disease, acne can persist throughout life and leave permanent scarring on the face as a result. Four distinct processes are believed to play critical roles in the formation of acne lesions: alteration of keratinization processes, leading to comedo formation; follicular colonization by Propionibacterium acnes; increased sebum production and inflammatory mediators around pilosebaceous units. [3][4][5] Several medications that have been devised to target these pathogenic mechanisms have demonstrated modest efficacy, but their use is also accompanied by potentially serious side-effects.6,7The exact sequence of events and how they are interconnected is still unknown, due to the inherent complexity of this disease. Ongoing research is modifying the classical view of acne pathogenesis through identification of underlying mechanisms for previous theories and experimental findings. Recently, researchers from diverse academic disciplines including dermatology, immunology, microbiology and endocrinology have reported novel concepts for acne physiopathology by employing cutting-edge experimental methods and academic approaches.The four central factors that contribute to acne physiopathology are inflammation, colonization with P. acnes, increased sebum production and hypercornification of the pilosebaceous duct. Recent research suggests that these factors are much more interrelated than has been previously understood. Novel factors that could contribute to acne physiopathology include inflammasomes, T helper (Th)17 cell immunology, P. acnes sequence type and nutritional factors.In this article we review the most recent findings in acne physiopathology. We focus on specific issues associated with each of the four pathogenic factors, as well as some additional interesting research pathways, which may provide novel frameworks for improving our understanding of the disease pathogenesis and development of new medications. Finally, we provide a brief outlook of the prospects for this intriguing field of dermatolo...

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Section: Recent Findingsmentioning

confidence: 72%

Section: Outlook and Future Perspectivesmentioning

confidence: 99%

What's new in the physiopathology of acne?

2015

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“…Four ounces of shrimp provides about 325 -375 milligrams of omega-3 fatty acids [118]. After 10 weeks of omega-3 fatty acid supplementation, inflammatory and non-inflammatory acne lesions decreased significantly [105]. Isotretinoin, Retinol (Vitamin A), carotenoids (provitamin A) and retinoids (Vitamin A metabolites) are absorbed better with parallel intake of vegetable oils [11].…”

Section: Exhibit 3 Acne Myths/misconception Vs Study Results Myth/mismentioning

confidence: 99%

Acne Protection: Measures & Miseries

2019

ARC Journal of Pharmaceutical Sciences

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“…Linoleic acid is the most common fatty acid applied in cosmetic as it moisturizes the skin and for acne treatment. The anti-inflammatory action proved that the application of γ-linoleic acid or omega-3 rich oil on 45 participants decreased moderate acne significantly (Jung et al 2014). On another note, fatty acids are reported to increase absorbing effect of skin.…”

Section: Fatty Acidsmentioning

confidence: 97%