Effect of Dietary Supplementation with Broccoli on X-Irradiation-Induced Enzyme Changes in the Guinea Pig

Hilf, Russell; R, Adachi; Eckfeldt, Gladys A.

doi:10.2307/3571070

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…There are large numbers of reports studying effects of radiation exposure and countermeasures using both X-rays and c-rays (Bianchi 1963;Osmond et al 1966;Jacquet et al 1994). Several countermeasures such as metformin, N-acetyl cysteine, corticosteroids, piracetam, and barium chloride have been evaluated using the guinea pig as an animal model (Rosenthal et al 1960;Hilf et al 1961;Wisniewski et al 1972;Altas et al 2006;Gulbahar et al 2009;Zhu & Liu 2009;Mujica-Mota et al 2014). This model has also been used to specifically study radiation-induced nasal and ear injuries and mitigation by various agents.…”

Section: Guinea Pigmentioning

confidence: 99%

A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures

Singh

Seed²

2017

International Journal of Radiation Biology

142

103

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Purpose: The increasing global risk of nuclear and radiological accidents or attacks has driven renewed research interest in developing medical countermeasures to potentially injurious exposures to acute irradiation. Clinical symptoms and signs of a developing acute radiation injury, i.e. the acute radiation syndrome, are grouped into three sub-syndromes named after the dominant organ system affected, namely the hematopoietic, gastrointestinal, and neurovascular systems. The availability of safe and effective countermeasures against the above threats currently represents a significant unmet medical need. This is the first article within a three-part series covering the nature of the radiation subsyndromes, various animal models for radiation countermeasure development, and the agents currently approved by the United States Food and Drug Administration for countering the medical consequences of several of these prominent radiation exposure-associated syndromes. Conclusions: From the U.S. and global perspectives, biomedical research concerning medical countermeasure development is quite robust, largely due to increased government funding following the 9/11 incidence and subsequent rise of terrorist-associated threats. A wide spectrum of radiation countermeasures for specific types of radiation injuries is currently under investigation. However, only a few radiation countermeasures have been fully approved by regulatory agencies for human use during radiological/nuclear contingencies. Additional research effort, with additional funding, clearly will be needed in order to fill this significant, unmet medical health problem. ARTICLE HISTORY

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Section: Guinea Pigmentioning

confidence: 99%

A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures

Singh

Seed²

2017

International Journal of Radiation Biology

142

103

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Radiation Biochemistry of Miscellaneous Organs

Altman

1970

Tissues and Body Fluids

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An Overview of Radiation Countermeasure Development in Radiation Research from 1954 to 2024

Kiang,

Cannon,

Singh

2024

Radiation Research

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Preparation for medical responses to major radiation accidents, further driven by increases in the threat of nuclear warfare, has led to a pressing need to understand the underlying mechanisms of radiation injury (RI) alone or in combination with other trauma (combined injury, CI). The identification of these mechanisms suggests molecules and signaling pathways that can be targeted to develop radiation medical countermeasures. Thus far, the United States Food and Drug Administration (U.S. FDA) has approved six countermeasures to mitigate hematopoietic acute radiation syndrome (H-ARS), but no drugs are available for prophylaxis and no agents have been approved to combat the other sub-syndromes of ARS, let alone delayed effects of acute radiation exposure or the effects of combined injury. From its inception, Radiation Research has significantly contributed to the understanding of the underlying mechanisms of radiation injury and combined injury, and to the development of radiation medical countermeasures for these indications through the publication of peer-reviewed research and review articles.

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Effect of Dietary Supplementation with Broccoli on X-Irradiation-Induced Enzyme Changes in the Guinea Pig

Cited by 3 publications

References 5 publications

A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures

A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures

Radiation Biochemistry of Miscellaneous Organs

An Overview of Radiation Countermeasure Development in Radiation Research from 1954 to 2024

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