Sixty growing New Zealand White (NZW) rabbits at 6 weeks of age and average body weight of 702±1.71g were used in the present study. The rabbits were randomly assigned to 5 equal treatment groups (n=12/group). Rabbits in treatment group 1 were fed basal diets without Pedicoccus acidilactici (T 1), while rabbits in treatment groups 2, 3, 4 and 5 were fed diets containing Pedicoccus acidilactici 0.1 g (1x10 9 cfu/g) /kg basal diet for different periods once a week (T 2), twice a week (T 3), skip a day (T 4) and through the experimental days (T 5). The experimental lasted for 8 weeks. Result show that rabbits in T 2 and T 3 groups recorded significantly (P≤ 0.01) and (P <0.05) higher final body weight, daily weight gain and improved feed conversion ratio. Once a week system (T2) had significantly the best values of CP, CF, EE, DCP, TDN, DE digestibility values, carcass weight and dressing percentages as compared to other treatment groups. Moreover, total protein, AST, albumin, total cholesterol, total lipids and LDL were significantly (P≤0.01) decreased in T 2. However, there were a significant increase in WBCs, IgG and IgM with T 2 group. Pediococcus acidilactici (PA) supplementation increased significant the population of total bacterial count in T 2 , T 3 and T 4 as compare toT 1 and T 5 while , total volatile fatty acid and ammonia concentration were not significantly affected by the different treatments. Rabbits in T 2 and T 3 have more villi and intestinal glands of the tunica mucosa, also T 2 , T 3 and T 4 groups were recorded high economic efficiency. Conclusively, it is concluded that supplemented 0.1g Pedicoccus acidilactici (1x10 9 cfu/g) /kg rabbit diet for once, twice a week improve growth performance traits and economic efficiency, without any adverse side effect of growing rabbits.