Effect of dietary supplementation of ginger and turmeric rhizomes on angiotensin-1 converting enzyme (ACE) and arginase activities in L-NAME induced hypertensive rats

Akinyemi, Ayodele Jacob; Thomé, Gustavo R.; Morsch, Vera Maria; Stefanello, Naiara; Goularte, Jéferson Ferraz; Belló‐Klein, Adriane; Oboh, Ganiyu; Schetinger, Maria Rosa Chitolina

doi:10.1016/j.jff.2015.06.011

Cited by 79 publications

(55 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The diets were freshly formulated according to a modified method of Akinyemi et al (; (Table ). The dose used in this study was according to a recent work by Akinyemi et al ().…”

Section: Methodsmentioning

confidence: 99%

“…Curcuminoids compound is the major phytochemicals and has been reported to possess antioxidant, antihypertensive, antihypercholesterolemic and antiplatelet properties (Chan et al, ; Prakash et al, ). Recently, the antihypertensive effects of these rhizomes have been demonstrated via mechanisms that may include vasodilation and prevention of inflammation (Akinyemi et al, ). Like ginger, there is limited information on their mechanism of action as inhibitor of platelet aggregation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary Supplementation of Ginger and Turmeric Rhizomes Modulates Platelets Ectonucleotidase and Adenosine Deaminase Activities in Normotensive and Hypertensive Rats

et al. 2016

Self Cite

View full text Add to dashboard Cite

Hypertension is associated with platelet alterations that could contribute to the development of cardiovascular complications. Several studies have reported antiplatelet aggregation properties of ginger (Zingiber officinale) and turmeric (Curcuma longa) with limited scientific basis. Hence, this study assessed the effect of dietary supplementation of these rhizomes on platelet ectonucleotidase and adenosine deaminase (ADA) activities in Nω-nitro-l-arginine methyl ester hydrochloride (l-NAME) induced hypertensive rats. Animals were divided into seven groups (n = 10): normotensive control rats; induced (l-NAME hypertensive) rats; hypertensive rats treated with atenolol (10 mg/kg/day); normotensive and hypertensive rats treated with 4% supplementation of turmeric or ginger, respectively. After 14 days of pre-treatment, the animals were induced with hypertension by oral administration of l-NAME (40 mg/kg/day). The results revealed a significant (p < 0.05) increase in platelet ADA activity and ATP hydrolysis with a concomitant decrease in ADP and AMP hydrolysis of l-NAME hypertensive rats when compared with the control. However, dietary supplementation with turmeric or ginger efficiently prevented these alterations by modulating the hydrolysis of ATP, ADP and AMP with a concomitant decrease in ADA activity. Thus, these activities could suggest some possible mechanism of the rhizomes against hypertension-derived complications associated to platelet hyperactivity. Copyright © 2016 John Wiley & Sons, Ltd.

show abstract

“…The diets were freshly formulated according to a modified method of Akinyemi et al (; (Table ). The dose used in this study was according to a recent work by Akinyemi et al ().…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dietary Supplementation of Ginger and Turmeric Rhizomes Modulates Platelets Ectonucleotidase and Adenosine Deaminase Activities in Normotensive and Hypertensive Rats

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…52 The activities of some key enzymes, such as ACE and arginase, were inhibited, and a concomitant increase in NO level was observed. 54 Simultaneously, the antihypertensive effect of ginger was also associated with the platelet hyperactivity 55 and potential neuroprotective effects. 69 Lipid abnormalities are one of the major risk factors for CVD in peritoneal dialysis (PD) patients.…”

Section: Cardiovascular Diseasementioning

confidence: 99%

Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review

Jing

Bao

et al. 2017

Annals of the New York Academy of Sciences

127

View full text Add to dashboard Cite

In recent years, metabolic syndromes (MetSs), including diabetes mellitus, dyslipidemia, and cardiovascular diseases, have become a common health problem in both developed and developing countries. Accumulating data have suggested that traditional herbs might be able to provide a wide range of remedies in prevention and treatment of MetSs. Ginger (Zingiber officinale Roscoe, Zingiberaceae) has been documented to ameliorate hyperlipidemia, hyperglycemia, oxidative stress, and inflammation. These beneficial effects are mediated by transcription factors, such as peroxisome proliferator-activated receptors, adenosine monophosphate-activated protein kinase, and nuclear factor κB. This review focuses on recent findings regarding the beneficial effects of ginger on obesity and related complications in MetS and discusses its potential mechanisms of action. This review provides guidance for further applications of ginger for personalized nutrition and medicine.

show abstract

“…(Ghayur & Gilani, ). Also, ginger has an effect on angiotensin‐converting enzyme that is a central component of the renin‐angiotensin system and controls BP by constriction of blood vessels and regulating the volume of fluids in the body (Akinyemi, Ademiluyi, & Oboh, ; Akinyemi et al, ).…”

Section: Discussionmentioning

confidence: 99%

Does ginger supplementation lower blood pressure? A systematic review and meta‐analysis of clinical trials

Hasani

Arab

Hadi

et al. 2019

Phytotherapy Research

View full text Add to dashboard Cite

The aim of the present systematic review and meta‐analysis was to determine the efficacy of ginger supplementation on blood pressure (BP). PubMed, Scopus, ISI Web of Science, Cochrane Library, and Google Scholar were comprehensively searched until September 2018. Human clinical trials, which reported the effect of ginger supplementation on aortic and/or brachial BP, were included. Mean differences were pooled using a random effects model. Standard methods were used for assessment of heterogeneity, sensitivity analysis, and publication bias. Total of six randomized clinical trials (345 participants) were included in the meta‐analysis. Pooled analysis suggested that ginger supplementation can reduced systolic BP (MD: −6.36 mmHg, 95% confidence interval [−11.27, −1.46]; I2 = 89.8%; P = .011) and diastolic BP (MD: −2.12 mmHg, 95% confidence interval [−3.92, −0.31]; I2 = 73.4%; P = .002). When studies were categorized based on participants' mean age, ginger dosage and duration of intervention, systolic BP and diastolic BP were significantly decreased only in the subset of studies with mean age ≤ 50 years, follow‐up duration of ≤8 weeks and ginger doses ≥3 g/d. Our findings revealed that ginger supplementation has favorable effects on BP. Nonetheless, further studies are warranted before definitive conclusions may be reached.

show abstract

Effect of dietary supplementation of ginger and turmeric rhizomes on angiotensin-1 converting enzyme (ACE) and arginase activities in L-NAME induced hypertensive rats

Cited by 79 publications

References 41 publications

Dietary Supplementation of Ginger and Turmeric Rhizomes Modulates Platelets Ectonucleotidase and Adenosine Deaminase Activities in Normotensive and Hypertensive Rats

Dietary Supplementation of Ginger and Turmeric Rhizomes Modulates Platelets Ectonucleotidase and Adenosine Deaminase Activities in Normotensive and Hypertensive Rats

Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review

Does ginger supplementation lower blood pressure? A systematic review and meta‐analysis of clinical trials

Contact Info

Product

Resources

About