Effect of Dietary Sodium Chloride on the Development of Renal Glomerular and Vascular Lesions in Hypertensive Rats

Liu, Dennis T.; Birchall, Ian; Kincaid‐Smith, Priscilla; Whitworth, Judith A.

doi:10.1111/j.1440-1681.1993.tb03014.x

Cited by 9 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In unilaterally nephrectomized rats, blood pressure rises between 1-2 weeks after start of DOCA-salt treatment (18)(19)(20)(21)(22)(23). After 4 weeks, blood pressure has further increased and remains elevated even after stopping steroid treatment (post-DOCA-salt hypertension) (24).…”

Section: Discussionmentioning

confidence: 99%

Effects of Centrally Administered Losartan on Deoxycorticosterone-salt Hypertension Rats

Park

Leenen

2001

J Korean Med Sci

View full text Add to dashboard Cite

INTRODUCTIONIn deoxycorticosterone acetate (DOCA)-salt hypertensive rats the development and maintenance of hypertension is considered to be independent of the renin-angiotensin system, because plasma renin in this model is low (1), and peripheral administration of angiotensin converting enzyme (ACE) inhibitors (2) or angiotensin (Ang) II receptor antagonists (3) has no effect on blood pressure (BP). However, there is some evidence for a role of the brain renin-angiotensin system in the pathogenesis of DOCA-salt hypertension in rats.DOCA-salt-treated rats show higher Ang II receptor density in brain areas involved in cardiovascular regulation, such as the nucleus of solitary tract, area postrema, median preoptic nucleus, subfornical organ, and solitary vagal area (4-6), and have elevated levels of renin and Ang II in hypothalamus and brain stem nuclei (7,8). Acute intracerebroventricular (icv) administration of captopril decreases the blood pressure of DOCA-salt hypertensive rats (9). Chronic icv administration of captopril attenuates the development of hypertension in DOCA-salt hypertensive rats (10). However, the interpretation of these findings is complicated because ACE is involved in the metabolism of various peptides that may participate in regulating BP, including bradykinin, enkephalin and substance P (11).Three studies assessed the effects of icv Ang II receptor antagonists on BP in DOCA-salt hypertensive rats. Acute icv administration of salarasin did not lower BP during 30 min of follow-up (12). In contrast, injection of losartan icv or into the rostral part of the third ventricle did lower BP for more than 1 hr in 4 weeks DOCA-salt hypertensive rats (13). Moreover, continuous icv infusion of CV-11974 (active metabolite of candesartan) for 7 days lowered BP from the fourth day after infusion (14). However, because hemodynamic measurements in these studies were done under anesthesia in 4 weeks and 6 weeks DOCA-salt hypertensive rats, the role of brain Ang II in the development of the hypertension in the DOCA-salt hypertensive rat model is not known yet.The aim of the present study was to determine the acute central effects of the type 1 Ang II (AT1) receptor antagonist losartan in conscious DOCA-salt hypertensive rats, at either 2 weeks during the development of the hypertension or at 4 weeks in the maintenance phase of the hypertension. MATERIALS AND METHODS AnimalsMale Wistar rats aged 5 weeks, weighing 140-170 g, were J Korean Med Sci 2001; 16: 553-7 ISSN 1011-8934 Copyright � The Korean Academy of Medical Sciences 553 Effects of Centrally Administered Losartan on Deoxycorticosteronesalt Hypertension RatsTo investigate whether brain AT1 receptor stimulation contributes as a hypertensive mechanism to deoxycorticosterone acetate (DOCA)-salt hypertension, losartan (1 mg/4 L) or artificial cerebrospinal fluid (aCSF) was injected into the lateral cerebral ventricle in conscious control uninephrectomized Wistar rats or rats with DOCA-salt for 2 or 4 weeks, and mean arterial pressure (MAP) and heart r...

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Centrally Administered Losartan on Deoxycorticosterone-salt Hypertension Rats

Park

Leenen

2001

J Korean Med Sci

View full text Add to dashboard Cite

show abstract

“…In unilaterally nephrectomized rats, blood pressure rose between 1-2 weeks after beginning DOCA-salt treatment. [18][19][20][21][22][23] After 4 weeks, blood pressure further increased and remained elevated even after stopping steroid treatment (post-DOCA-salt hypertension). 24 solitary vagal area.…”

Section: Discussionmentioning

confidence: 99%

Effect of Central Losartan on DOCA-Salt Hypertension Rats

Lee

Park

et al. 2004

Korean Circ J

View full text Add to dashboard Cite

Background: The purpose of this study was to investigate whether brain AT1 receptor stimulation contributes as a hypertensive mechanism to deoxycorticosterone acetate (DOCA)-salt hypertension. Methods: 1) Acute injection: Losartan (1 mg/4 uL) or artificial cerebrospinal fluid (aCSF) was injected into the lateral cerebral ventricle (icv) of conscious control uninephrectomized Wistar rats or rats with DOCA-salt at 2 or 4 weeks, and mean arterial pressure (MAP) and heart rates (HR) were recorded. 2) Chronic injection: Using osmotic minipump, losartan (1 mg/kg/d) or aCSF was injected to a sham group or three DOCA-salt rat groups [icv-aCSF, icv-losartan, sc-losartan (subcutaneous) groups] for 4 weeks, after which the MAP and HR were recorded in addition to the weights of the left (LV) and right ventricles (RV) and kidneys. Results: 1) Acute injection: In rats treated with DOCA-salt, resting MAP significantly increased compared to the control group [144±6 mmHg (2 weeks), 170± 5 mmHg (4 weeks) vs 115-120 mmHg (controls)]. MAP decreased significantly (2 weeks, 4 weeks) at 4, 8, 24 hours after icv injection of losartan to the level of the control group. 2) Chronic injection: The general trend showed that MAP decreased more in the icv-losartan group than in the icv-aCSF group (127±15.2 mmHg vs 141.1±5.5 mmHg, p=0.0578). In all DOCA-salt groups, no differences in RV weight were found. In the icv-aCSF and sclosartan groups, the kidney weight increased compared to the control group, but there was no difference in LV and kidney weight between the icv-losartan group and the control group. Conclusions: Normalization of MAP after acute or chronic icv administration of the AT 1 receptor antagonist suggests that the stimulation of the brain AT 1 receptor plays a significant role in the development and maintenance of hypertension in the DOCAsalt hypertensive rat model. Losartan icv injection appeared to have a protective effect on the heart and kidney.

show abstract

“…При поиске по ключевым словам (NaCl, renovascular hypertension, rats) было найдено в базах 53 публикации (из них 6 обзоров литературы). После исключения статей по заголовкам, резюме, а также повторных публикаций для метаанализа было отобрано 9 публикаций [18][19][20][21][22][23][24][25][26], в которых сравнивалась величина подъема АД после стенозирования почечной артерии у крыс, содержащихся на стандартной диете и высокосолевой диете. В 8 публикациях оценивалось влияние диеты на АРП.…”

Section: влияние диеты с повышенным содержанием Nacl на развитие ургunclassified

Meta-Analysis of Dependence of the Development of Experimental Renovascular Hypertension “2 Kidneys, 1 Clamp” on Lifestyle Factors

Kuzmenko,

Tsyrlin,

Pliss

2023

Transl. med. (Print)

View full text Add to dashboard Cite

Background. According to WHO controllable hypertension risk factors include an unhealthy diet, physical inactivity, and wrong daily routine. To date, a large number of experimental studies in rats have studied the effect on the development of unilateral renovascular hypertension (URH) of dietary supplements (minerals, vitamins, flavonoids, caffeine, fats, carbohydrates), physical activity and melatonin therapy.Objective. To conduct a meta- analysis of studies on risk factors for the development of URH.Design and methods. The search for publications was carried out in the PubMed, Scopus, Google Scholar databases. A total of 52 publications were selected.Results. The severity of hypertension decreases when the diet is enriched with potassium, as well as with various antioxidants (vitamin C, flavonoids, melatonin), which reduce oxidative stress in the ischemic kidney. In addition, physical activity can help reduce blood pressure in URH, but at the same time, it increases myocardial hypertrophy. There was no hypertensive effect of increased sodium chloride intake in renal artery stenosis, and no effect of calcium or magnesium supplementation on the URH development. At the same time, caffeine intake significantly increases plasma renin activity and blood pressure in URH.Conclusion. The majority of experimental studies included in our meta-analysis investigated the influence of factors on the development of URH, but not their effect on blood pressure in the chronic stage of URH.

show abstract

Effect of Dietary Sodium Chloride on the Development of Renal Glomerular and Vascular Lesions in Hypertensive Rats

Cited by 9 publications

References 29 publications

Effects of Centrally Administered Losartan on Deoxycorticosterone-salt Hypertension Rats

Effects of Centrally Administered Losartan on Deoxycorticosterone-salt Hypertension Rats

Effect of Central Losartan on DOCA-Salt Hypertension Rats

Meta-Analysis of Dependence of the Development of Experimental Renovascular Hypertension “2 Kidneys, 1 Clamp” on Lifestyle Factors

Contact Info

Product

Resources

About