Effect of dietary restriction on triglyceride levels in the uterus isolated from pregnant rats. Influences of prostaglandins and indomethacin

Sterin, A.B.F.; Linares, J.A.; Goldraij, A

doi:10.1016/0952-3278(89)90097-5

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…Reduced lipid catabolism at menopause can lead to oxidation of excess circulating lipids and systemic inflammation. Exogenous estrogens can reduce the serum levels of several markers for inflammation in post-menopausal women (Stork et al 2002). However, germ cell-depleted ovaries do not provide cyclic estrogens.…”

Section: Inflammationmentioning

confidence: 99%

“…The beneficial effects of dietary restriction on glucose and lipid metabolism in intact female rodents are distinct from the effects in ovariectomized rodents, supporting a central role for the ovaries in female metabolic health (Monteiro et al 2014;Sterin et al 1989). In addition, naturally menopausal women possess a health advantage over surgically menopausal women, suggesting that even senescent ovaries provide a health advantage, independent of active germ cells (Yoshida et al 2011).…”

Section: Introductionmentioning

confidence: 99%

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Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice

et al. 2018

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Cardiovascular disease, rare in premenopausal women, increases sharply at menopause and is typically accompanied by chronic inflammation. Previous work in our laboratory demonstrated that replacing senescent ovaries in post-reproductive mice with young, actively cycling ovaries restored many health benefits, including decreased cardiomyopathy and restoration of immune function. Our objective here was to determine if depletion of germ cells from young transplanted ovaries would alter the ovarian-dependent extension of life and health span. Sixty-day-old germ cell-depleted and germ cell-containing ovaries were transplanted to postreproductive, 17-month-old mice. Mean life span for female CBA/J mice is approximately 644 days. Mice that received germ cell-containing ovaries lived 798 days (maximum = 815 days). Mice that received germ cell-depleted ovaries lived 880 days (maximum = 1046 days), 29% further past the time of surgery than mice that received germ cellcontaining ovaries. The severity of inflammation was reduced in all mice that received young ovaries, whether germ cell-containing or germ cell-depleted. Aging-associated inflammatory cytokine changes were reversed in post-reproductive mice by 4 months of new-ovary exposure. In summary, germ cell depletion enhanced the longevity-extending effects of the young, transplanted ovaries and, as with germ cell-containing ovaries, decreased the severity of inflammation, but did so independent of germ cells. Based on these observations, we propose that gonadal somatic cells are programed to preserve the somatic health of the organism with the intent of facilitating future germline transmission. As reproductive potential decreases or is lost, the incentive to preserve the somatic health of the organism is lost as well.

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Section: Inflammationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice

et al. 2018

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“…Tests with laboratory animals have in general been carried out by applying very severe food restrictions throughout the entire pregnancy or at certain intervals during pregnancy (Pond and Mersmann, 1988;Sterin et al, 1989;Firmansyah et (Carreti et al, 1992;Thomsen et al, 1993).…”

mentioning

confidence: 99%

Relationship between moderate food restriction during pregnancy and Fe, Zn and Cu contents in maternal tissues and foetuses

Vaquero¹,

Navarro²

1996

Reprod. Nutr. Dev.

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Glucose, glycogen and triglyceride metabolism, as well as prostaglandin production in uterine strips and in embryos from diabetic pregnant rats. Influences of the presence of substrate in the incubation medium

et al. 1993

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Effect of dietary restriction on triglyceride levels in the uterus isolated from pregnant rats. Influences of prostaglandins and indomethacin

Cited by 4 publications

References 28 publications

Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice

Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice

Relationship between moderate food restriction during pregnancy and Fe, Zn and Cu contents in maternal tissues and foetuses

Glucose, glycogen and triglyceride metabolism, as well as prostaglandin production in uterine strips and in embryos from diabetic pregnant rats. Influences of the presence of substrate in the incubation medium

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