Effect of Dietary Regimen on Cessation of Uptake of Macromolecules by Piglet Intestinal Epithelium (Closure) and Transport to the Blood

Lecce, James G.

doi:10.1093/jn/103.5.751

Cited by 88 publications

(67 citation statements)

References 17 publications

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“…Factors to be considered in explanation of these observations include potential interactions of GI tract maturation with parallel changes in the composition of colostrum that are associated with its transition to mature milk. In the pig, gut closure occurs within 24-48 h of birth (Leece 1973). This event Lactocrine effects on cervical development prevents further transfer of macromolecules, including potential MbFs, across the GI tract and into the neonatal circulation.…”

Section: Discussionmentioning

confidence: 99%

“…Insulin-like growth factor 1 (IGF1; 7.6 kDa), another member of the insulin family of hormones, is found in porcine colostrum at high concentrations (Simmen et al 1990a, which decline within the first 24-36 h of lactation during the transition from colostrum to mature milk (Klobasa et al 1987, Nguyen et al 2001. In the porcine neonate, a window for transmission of macromolecules, including MbFs, is open before gut closure, which is estimated to occur within 48 h of birth (Leece 1973). Orally administered IGF1 is locally bioactive in neonatal pigs, promoting intestinal crypt cell proliferation and increasing villus height (Xu et al 1994, Burrin et al 1996, Houle et al 2000.…”

Section: Introductionmentioning

confidence: 99%

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Effects of age, nursing, and oral IGF1 supplementation on neonatal porcine cervical development

Camp¹,

Wiley²,

Boulos³

et al. 2014

Reproduction

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Nursing supports neonatal porcine uterine and testicular development, however, lactocrine effects on cervical development are undefined. Studies were conducted to determine the effects of i) age and the imposition of the lactocrine-null state from birth (postnatal day 0 (PND0)) by milk replacer feeding on cervical histology; ii) imposition of the lactocrine-null state for 2 days from birth on cervical cell proliferation, as reflected by proliferating cell nuclear antigen immunostaining; and iii) a single feeding of colostrum or milk replacer, administered at birth, with or without oral IGF1, on cervical cell proliferation and phosphorylated AKT (pAKT) and B-cell lymphoma 2 (BCL2) protein levels at 12 h postnatal. Cervical crypt depth and height of luminal epithelium (LE) increased with age by PND14, when both responses were reduced in replacer-fed gilts. Cell proliferation was reduced in LE at PND2, and in crypt epithelium and stroma by PND14 in replacer-fed gilts. Returning replacer-fed gilts to nursing on PND2 did not rescue the cervical phenotype by PND14. A single feeding of colostrum, but not milk replacer, was sufficient to support cervical cell proliferation at 12 h postnatal. IGF1 supplementation induced cell proliferation in replacer-fed gilts, and increased cervical pAKT and BCL2 levels in colostrum-fed gilts and replacer-fed gilts at 12 h postnatal. Results indicate that age and nursing support porcine cervical development, support is initiated at first ingestion of colostrum, IGF1 may be lactocrine-active, and identification of lactocrine-active factors can be accomplished by 12 h postnatal using this bioassay system.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of age, nursing, and oral IGF1 supplementation on neonatal porcine cervical development

Camp¹,

Wiley²,

Boulos³

et al. 2014

Reproduction

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“…IgG from the sow's colostrum is absorbed by the newborn via enterocytes [22,23]. A rapid "closure" of the gut for the macromolecular uptake occurs within 24 and 48 h after birth [25]. Colostral intake is essential for efficient immune reactions, and the germ-free colostrum deprived "virgin" piglet can serve as model for the assessment of development of defence against of pathogens [24].…”

Section: Gut Function and Immunitymentioning

confidence: 99%

Postnatal development of intestinal immune system in piglets: implications for the process of weaning

Stokes¹,

Bailey²,

Haverson³

et al. 2004

Anim. Res.

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-European-wide directives are in place to establish a sustainable production of pigs without using production enhancers and chemotherapeutics. Thus, an economically-viable pig production is now only possible when the physiological mechanisms of defense against pathogens and tolerance against nutrients and commensal bacteria in the intestinal immune system are taken into account. During the postnatal period the piglet is facing first the time large amounts of new antigens and at weaning a second wave of nutritional antigens is entering the intestinal tract. The appropriate development of humoral and cellular functions of the intestinal immune system is essential for optimum growth and performance of the piglets. The integrity of the intestinal surfaces is a prerequisite of intestinal immunity and tolerance. Secretory IgA serves to exclude harmful antigens from uptake. The induction of intestinal immune reactions starts with antigen presentation by professional antigen presenting cells of Peyer's patches and mesenteric lymph nodes. In addition, the intestinal lamina propria serves as a mucosal compartment for regulation of immune responses. Here especially T regulatory cells (CD4 + CD25 + ) have their function for maintaining intestinal homeostasis. The network of mucosal T and B cells develops after birth in a programmed sequence; it is almost completed at week 7 after birth. Weaning is associated with changes in the regulation of the lymphoid cells in the mucosa. In small and large intestine increases in pro-and anti-inflammatory cytokines were observed after weaning in lymphocytes. Epithelial cells were studied both in intestinal samples and in vitro. Here the cytokine patterns provide evidence that weaning is inducing a transient inflammation of the mucosa. Piglets weaned under conventional conditions have a thicker mucosa than pigs weaned from isolators. Cells of isolator-reared pigs show slightly higher levels of activation markers -probably * Corresponding author: hermann-josef.rothkoetter@medizin.uni-magdeburg.de 326 C.R. Stokes et al.reflecting the interaction of the foreign protein derived from bovine milk. The results presented in this overview demonstrate that further effort is necessary to elucidate the function of the porcine intestinal immune system in the postnatal period and at the time of weaning to provide criteria for porcine intestinal health.inflammation / intestinal immunity / mucosa / nutrition / pig / postnatal / weaning Résumé -Développement postnatal de l'immunité intestinale chez le porcelet : implications pour le processus de sevrage. Des directives européennes ont été adoptées, en vue de mettre en place une production durable de porcs sans facteurs de croissance ni antibiotiques. Dans ce contexte, un élevage porcin ne sera économiquement viable que si sont pris en compte les mécanismes physiologiques de défense contre les agents pathogènes, et de tolérance vis-à-vis des aliments et des bactéries commensales, mécanismes engageant le système immunitaire intestinal des animaux. ...

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“…On the other hand, in calves, piglets, rats and lambs it has been shown that the preclosure period can be shortened by the ingestion of a large amount of colostrum after birth (22,45,46,50,58,83). Apparently, at the time the pinocytotically active epithelial cells are saturated, additional uptake of macromolecules including immunoglobulins no longer occurs.…”

Section: Introductionmentioning

confidence: 99%

Review papers

Vellenga

et al. 1985

Veterinary Quarterly

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Effect of Dietary Regimen on Cessation of Uptake of Macromolecules by Piglet Intestinal Epithelium (Closure) and Transport to the Blood

Cited by 88 publications

References 17 publications

Effects of age, nursing, and oral IGF1 supplementation on neonatal porcine cervical development

Effects of age, nursing, and oral IGF1 supplementation on neonatal porcine cervical development

Postnatal development of intestinal immune system in piglets: implications for the process of weaning

Review papers

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