Effect of Dietary Regimen on Cessation of Intestinal Absorption of Large Molecules (Closure) in the Neonatal Pig and Lamb

The effect of vaccination regimen on the transfer of foot and mouth disease antibodies from the sow to her piglets

“…The fact that most or all absorption of colostral antibodies through the intestinal wall of the newborn piglet occurs during the first 24-48 h after birth (Lecce & Morgan, 1962;Bourne, 1971;Dujin, 1971;Yabiki, Kashiwazaki & Namioka, 1974) led us to consider whether the vaccination regimen of the sow, and hence the proportion of the various antibody classes in the sows serum during the critical few days around farrowing, might influence the passive transfer of maternally derived antibodies to the piglets. The predominant antibody class in the piglets is of special importance since IgG (half life of 6-5-22-5 days), IgM (half life of 1 [3-7-8 days) and IgA (half life of 2-35 days) vary considerably in their decay rates (Porter & Hill, 1970;Curtis & Bourne, 1971;1973;Francis & Black, 1984).…”

Enteric Colibacillosis: Vaccination In Experimentally Infected Early Weaned Piglets

“…This suggestion is supported by the fact that serum antibody was not detected in 14-day-old non-vaccinated piglets derived from normal sows, whereas nonvaccinated piglets derived from vaccinated SOWS had antibody against E. coli El45 at this time. This suggests that the vaccinated SOWS probably passed large amounts of antibody to their offspring, since piglets cease to absorb immunoglobulins after the first 24-36 hr of life (Lecce and Morgan, 1962), and passively acquired antibody falls to very low levels during the first 2-3 wk of life (Shape, 1965;Arbuckle, 19683). Circulating antibody in piglets before challenge was associated in this study with either very mild diarrhoea or no diarrhoea at all.…”

Acquisition of passive immunity in domestic ungulates

“…Indeed, Lecce and Morgan (1962) and Payne and March (1962 a,b) have established that closure was delayed in starved new-born lambs and piglets. This effect of colostrum on closure could be linked to the fact that it contains cellular growth factors (Iivanainen et al, 1992) which have now been identified.…”

“…Turnover starts in the crypts of Lieberkuhn and moves up to the apex of the villi, where some macromolecule absorption is still possible (El-Nageh, 1967 a,b). While in normal conditions, closure is complete 24 to 36 h after birth (Lecce and Morgan, 1962 ;McCoy et al, 1970), there is a significant reduction before this time in both the young ruminant and the piglet (Bourne and Curtis, 1973 ;Murata and Namioka, 1977;Matte et al, 1982). The rate of epithelium cell turnover is a complex process and is under the control of numerous factors linked directly to the animal or to external factors.…”