Effect of dietary protein on vitamin E levels in erythrocytes and tissues of rats.

Tissue Vitamin E Status Is Compromised by Dietary Protein Insufficiency in Young Growing Rats ,

“…Liver, testis, adrenal gland and spleen were not affected, whereas heart, lung, kidney, muscle, plasma, brain and adipose tissue were significantly lowered by di etary protein inadequacy. These data agree with the study of Mouri et al (1986), in which lung, kidney and muscle a-tocopherol concentrations were lower in rats fed a 10% casein diet than in rats fed a 20% casein diet. However, not only was our study more extensive, because we measured more tissues, but also the 2x2 factorial design enabled us to observe the effects of dietary protein insufficiency at both normal and high levels of dietary vitamin E. Two-way ANOVA revealed a significant interaction between at Swets 76861023 on June 3, 2009 jn.nutrition.org Downloaded from dietary protein and vitamin E level in their effects on tissue a-tocopherol concentrations in heart, brain and adipose tissue.…”

“…In the extreme form of protein malnutrition, kwashiorkor, there is inade quate synthesis of lipoprotein fractions necessary for the transport of triglycérides and other lipids from the liver, and this leads to accumulation of lipid in the liver (Whitehead and Alleyne 1972). Mouri et al (1986) speculated that a low protein intake may de crease the efficiency of tocopherol transport to tissue cells secondarily to a reduction in circulating lipoprotein containing a-tocopherol. However, in the present study it is unlikely that the 8% lactalbumin diet had such an extreme effect.…”

“…Rajaram et al (1977) reported lowered distribution of orally dosed all-rac-a-[5-CH3-3H]tocopherol in the liver cytosol of rats fed a 5% (wt/wt) casein diet. Mouri et al (1986) showed that a-tocopherol levels in RBC, kidney, lung and muscle were lower in rats fed a 10% casein diet compared with rats fed a 20% casein diet. In our previous report, we found that supplementing a low protein diet ¡containing 8% lactalbumin and 15% soybean oil) with 150 mg/kg diet of all-rac-atocopheryl acetate significantly decreased the thiobarbituric acid-reactive substances (TEARS) in plasma, heart and liver (but not in the remaining tissues measured) and restored the depressed activities of RBC Superoxide dismutase (SOD, EC 1.15.1.1) and catalase (Huang and Fwu 1992).…”