Effect of Dietary Protein on the Severity of Experimental Mouse Hepatitis

Hepatitis in Renal Dialysis Units

“…There is some evidence that dietary deficiency alone may play some part. Ruebner and Bramhall (1959) reported that mice fed on a decreased protein intake were more susceptible to their own type of viral hepatitis than those animals fed on a normal diet. However, any such effect may be further enhanced by the metabolic derangements present in uraemia.…”

Nutritional Factors in Host Resistance

“…Indeed, in the experiments of Hill and Garren (5) on fowl typhoid, protein has been advanced as a susceptibility factor. Ruebner and Bramhall (6) reported that low protein intake lowered resistance of mice to mouse hepatitis virus. Sprunt and Flanigan (7) have advanced the most complicated hypothesis of all, and believe that protein deficiency is cyclic in its effects on resistance to viral disease, leading first to susceptibility, then to resistance, and thence to susceptibility again.…”