Effect of Dietary Patterns on Measures of Lipid Peroxidation

Abstract

Background-Free radical-mediated oxidative damage to lipids is thought to be an important process in the pathogenesis of atherosclerosis. Although previous studies have demonstrated a beneficial impact of antioxidant vitamin supplements on lipid peroxidation, the effect of dietary patterns on lipid peroxidation is unknown. Methods and Results-During the 3-week run-in period of a randomized trial, 123 healthy individuals were fed a control diet, low in fruits, vegetables, and dairy products, with 37% of calories from fat. Participants were then randomized to consume for 8 weeks: (1) the control diet, (2) a diet rich in fruits and vegetables but otherwise similar to the control diet, and (3) a combination diet rich in fruits, vegetables, and low-fat dairy products and reduced in fat. Serum oxygen radical-absorbing capacity, malondialdehyde (an in vitro measure of lipid peroxidation), and breath ethane (an in vivo measure of lipid peroxidation) were measured at the end of run-in and intervention periods. Between run-in and intervention, mean (95% CI) change in oxygen radical-absorbing capacity (U/mL) was Ϫ35 (Ϫ93, 13) in the control diet, 26 (Ϫ15, 67) in the fruits and vegetables diet (Pϭ0.06 compared with control), and 19 (Ϫ22, 54) in the combination diet (Pϭ0.10 compared with control

Possible Role of Oxidative Stress in the Pathogenesis of Hypertension

“…In addition, blood pressure reductions began in the second week of intervention and continued for the 6-week duration of the study, reaching targets observed after drug therapy (34). A substudy using the DASH diet demonstrated that this modification in diet resulted in an increase in serum antioxidant capacity and a decrease in malondialdehyde, an in vitro marker of lipid peroxidation, suggestive of a reduction in oxidative stress (35). The DASH 2 study has further highlighted the benefit of following the combination DASH diet as well as reducing sodium intake.…”

Effet d'une alimentation riche en fruits et légumes sur les taux plasmatiques en antioxydants et des marqueurs des dommages oxydatifs

“…Toutefois, la plupart des études in vivo [14,18,23,24,29,30,33,53] montrent que la consommation en fruits et légumes chez des sujets en bonne santé n'entraîne pas de façon significative une diminution des dommages oxydatifs au niveau des lipides ou de l'ADN. Ces résultats sont évidemment décevants puisque cela est en contradiction avec le fait que la concentration plasmatique en antioxydants est augmentée après un apport interventionnel en fruits et légumes.…”

Effects of enhanced consumption of fruit and vegetables on plasma antioxidant status and oxidative resistance of LDL in smokers supplemented with fish oil

“…However, the beneficial effects of this level of consumption have not been examined. Studies to date have concentrated on dietary enhancement of volunteers with carotenoid-rich vegetables (Hininger et al, 1997;van het Hof et al, 1999;Bub et al, 2000;Chopra et al, 2000) or provided subjects with a highly controlled diet with a very high fruit and vegetable component (9-10 servings per day) (Cao et al, 1998;Miller et al, 1998). Previous studies attempting to increase fruit and vegetable consumption in free-living volunteers demonstrated increases in plasma antioxidants (Zino et al, 1997), but no significant increase in plasma antioxidant capacity (Record et al, 2001).…”