Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease

Collison, Kate S.; Maqbool, Zakia; Saleh, Soad; Inglis, Angela; Makhoul, Nadine J.; Bakheet, Razan; Al-Johi, Mohammed; Al-Rabiah, Rana; Zaidi, Marya Z.; Al‐Mohanna, Futwan

doi:10.1194/jlr.m800418-jlr200

Cited by 83 publications

(53 citation statements)

References 48 publications

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“…Studies performed on non-diabetic mice have correlated the histological hepatic changes caused by nonalcoholic fatty liver disease (NAFLD) to increased plasmatic lipids generated by the oral [29] administration of MSG. In contrast to the observations made by these authors, in the present study the hepatic histological analyses of the non-diabetic rats showed preserved hepatocytes and absence of lipid inclusions, likely due to the lack of alterations in the serum lipid levels in these animals.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Biochemical, Hematological and Histological Parameters in Non Diabetic and Diabetic Wistar Rats Fed with Monosodium Glutamate

Maluly¹,

Áreas²,

Borelli³

et al. 2013

FNS

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The parenteral or oral administration of monosodium glutamate (MSG) has been reported to have a deleterious effect on the hypothalamic arcuate nucleus, which changes appetite control. This alteration in function may lead to obesity and disorders related to metabolic syndrome, such as alterations in carbohydrate metabolism (glucose and insulin resistance), dyslipidemia and cardiovascular disease. This study evaluates the induction of metabolic alterations due to subchronic consumption of diets containing MSG at levels of 1.0%, 2.5% and 5.0%. Initially the animals (newborn male Wistar rats) consumed the diets containing MSG for a period of 70 days. At the end of this period diabetes was induced by streptozotocin (STZ) and the rats maintained on the same diets for additional 21 days. The induction of diabetes is based on the susceptibility of diabetic animals to metabolic disorders. Methods capable of evaluating the entire metabolic profile of the diabetic condition were used, including biochemical tests and tests able to detect alterations in the organs usually affected by this disease. It was concluded that the consumption of diets containing up to 5.0% MSG did not change the studied parameters for both: diabetic or non-diabetic animals. The alterations observed in the diabetic animals mainly reflected metabolic changes caused by the disease and were not related to the administration of MSG.

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Section: Resultsmentioning

confidence: 99%

Evaluation of Biochemical, Hematological and Histological Parameters in Non Diabetic and Diabetic Wistar Rats Fed with Monosodium Glutamate

Maluly¹,

Áreas²,

Borelli³

et al. 2013

FNS

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“…Subsequent studies of mice fed trans -fats have also demonstrated the development of NASH [10, 11, 27] and an increase in hepatocellular ballooning was noted even with a relatively low dose of dietary trans -fats in one study [10]. A subsequent study using AKR/J mice found that trans -fat feeding caused elevated aminotransferases but in contrast to the previous studies, significant liver histological changes were not identified in this mouse strain [12].…”

Section: Discussionmentioning

confidence: 99%

Dietary trans‐Fatty Acid Induced NASH is Normalized Following Loss of trans‐Fatty Acids from Hepatic Lipid Pools

Neuschwander‐Tetri

Ford

Acharya

et al. 2012

Lipids

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Previous experiments in mice showed that dietary trans-fats could play a role in non-alcoholic steatohepatitis (NASH) yet little is known about the accumulation trans-fats in hepatic lipid pools in relationship to liver injury. NASH is also associated with obesity yet improves with only modest weight loss. To distinguish the role of obesity versus sustained consumption of a trans-fat containing diet in causing NASH, mice with obesity and NASH induced by consuming a high trans-fat diet for 16 weeks were subsequently fed standard chow or maintained on trans-fat chow for another 8 weeks. The accumulation, partitioning and loss of trans-fats in the major hepatic lipid pools during and after trans-fat consumption were determined. Obese mice switched to standard chow remained obese but steatohepatitis improved. trans-fats were differentially incorporatedinto the majorhepatic lipid pools and the loss of trans-fats after crossover to control chow was greatest in the cholesteryl ester pool. In summary, dietary changes can improve the biochemical and histopathological changes of NASH despite persistent obesity in mice. Analysis of hepatic lipids confirmed that dietary trans-fats accumulate in the major lipid pools and are released differentially with diet normalization. The substantial loss of trans-fats from the cholesteryl ester pool in parallel with improvement in NASH suggests that this pool of trans-fats could play a role in the pathogenesis of NASH.

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“…Together with the high dietary fat consumption, monosodium L-glutamate (MSG) is added to food on a daily basis notably in Asian countries, including China (Beyreuther et al 2007;Narukawa et al 2011). Earlier studies have examined the effects of dietary fat and MSG either alone or in combination, on gene expression in murine liver, cardiac, and adipose tissues (Collison et al 2009;Collison et al 2011); and we have previously shown that dietary fat and MSG modifies circulating and tissue amino acid pools in growing pigs (Feng et al 2014).…”

Section: Introductionmentioning

confidence: 97%

Monosodiuml-glutamate and dietary fat exert opposite effects on the proximal and distal intestinal health in growing pigs

Feng

et al. 2015

Appl. Physiol. Nutr. Metab.

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The Chinese population has undergone rapid transition to a high-fat diet. Furthermore, monosodium L-glutamate (MSG) is widely used as a flavour enhancer in China. Previous studies have reported that high-fat diet modifies intestinal metabolism and physiology. However, little information is available on the effects of oral MSG on intestine, and no study focus on the interaction of dietary fat and MSG for intestinal health. The aim of the present study was to evaluate the effects of MSG and dietary fat on intestinal health in growing pigs, and to try to identify possible interactions between these 2 nutrients for such effects. A total of 32 growing pigs were used and fed with 4 isonitrogenous and isocaloric diets (basal diet, high-fat diet, basal diet with 3% MSG and high fat diet with 3% MSG). Parameters related to reactive oxygen species metabolism, epithelial morphology, pro-inflammation factors and tight junction protein expression and several species of intestinal microbe were measured. Overall, dietary fat and MSG had detrimental effects on several of the physiological and inflammatory parameters measured in the proximal intestine, while exerting beneficial effects on the distal intestine in growing pigs, with generally antagonistic effects. These results may be of particular relevance for nutritional concerns in patients with intestinal diseases.

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Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease

Cited by 83 publications

References 48 publications

Evaluation of Biochemical, Hematological and Histological Parameters in Non Diabetic and Diabetic Wistar Rats Fed with Monosodium Glutamate

Evaluation of Biochemical, Hematological and Histological Parameters in Non Diabetic and Diabetic Wistar Rats Fed with Monosodium Glutamate

Dietary trans‐Fatty Acid Induced NASH is Normalized Following Loss of trans‐Fatty Acids from Hepatic Lipid Pools

Monosodiuml-glutamate and dietary fat exert opposite effects on the proximal and distal intestinal health in growing pigs

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