Effect of dietary Lycium barbarum polysaccharide on growth performance and immune function of broilers

Liu, Y. L.; Yin, Runsheng; Liang, Saisai; Duan, Yulan; Yao, Jun; Yang, Xin

doi:10.3382/japr/pfw063

Cited by 26 publications

(15 citation statements)

References 33 publications

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“…Several published studies have demonstrated the effectiveness of CHMs in boosting immune system of livestock (Mao et al, 2005;Kim et al, 2008;Manzanilla et al, 2009;Liu et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Effects of fermented Chinese herbal medicines on milk performance and immune function in late-lactation cows under heat stress conditions

Shan

Guo²,

Sun

et al. 2018

Journal of Animal Science

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Heat stress (HS) causes significant economic losses and has become a continual challenge in the dairy industry worldwide. The objective of this study was to evaluate the effects of a dietary supplement on milk performance and immune function in late-lactation cows under HS conditions. The supplement was a fermented Chinese herbal medicines (CHMs) mixture consisting of 18 herbs. Forty lactating Holstein cows (560 ± 51.0 kg of initial BW, 230 ± 10.0 DIM, 16 ± 3.0 kg of milk per day) were randomly assigned into 4 treatment groups (10 cows per group). Each group was fed a dietary supplemented with 0, 25, 50, or 100 g CHMs per cow per day. Cows were housed at high ambient temperature-humidity index (average 74.5) for an experimental period of 42 d during the summer months. Milk yield, composition, immune responses involving blood lymphocyte apoptosis rate, serum biochemical parameters, and genes expression in lymphocytes were evaluated on days 14, 28, and 42, respectively. Results showed that milk yield, milk fat, and protein content were greater (all P < 0.05) for 50 or 100 g/d CHMs compared with the group without CHMs supplements throughout the experimental period. On the other hand, increasing CHMs dose demonstrated a greater lymphocyte or leukocyte count (P < 0.01). By flow cytometry analysis, early or late apoptosis rate of the lymphocytes was decreased (P < 0.05) by CHMs supplements. The immunity-related biochemistry and genes transcript responses involving cytokines (IL-1, IL-2, IL-6, and IL-12), apoptosis (Bak, Mcl-1, Bax, Bcl-2, Bcl-xl, and P53), and immunoglobulins (IgA, IgG, and IgM) were investigated. Compared with the unsupplemented group, the serum IL-2 and IL-6 levels, as well as IL-2 mRNA expression, increased (P < 0.05) for 100 g/d. However, the serum IL-1 level tended to decrease (P = 0.08) with increasing CHMs dose, and IL-1 mRNA expression was down-regulated (P = 0.02) by up to 24% for 100 g/d. Additionally, the serum Bax level decreased (P < 0.01) and Bcl-2 level increased (P = 0.01) for 100 g/d. Bax and Bak mRNA expressions were down-regulated (P < 0.05), and Bcl-2 and Bcl-xl expression were up-regulated (P < 0.05) for 50 or 100 g/d. The mRNA expressions of P53 and Mcl-1 were not affected by CHMs (P > 0.10). Besides, serum IgG levels were greater (P < 0.01) for 50 or 100 g/d, compared with unsupplemented group. In conclusion, CHMs supplements may improve milk performance and immune function in dairy cows under HS conditions.

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“…Several published studies have demonstrated the effectiveness of CHMs in boosting immune system of livestock (Mao et al, 2005;Kim et al, 2008;Manzanilla et al, 2009;Liu et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Effects of fermented Chinese herbal medicines on milk performance and immune function in late-lactation cows under heat stress conditions

Shan

Guo²,

Sun

et al. 2018

Journal of Animal Science

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show abstract

“…The assay was carried out via SYBR Premix Ex Taq kit (TaKaRa) on the IQ5 (Bio-Rad, Hercules, CA). Detailed reaction system was referred to our previous publishment ( Liu et al., 2017 ). Primer sequences used in the current study were all obtained from GenBank and shown in Table 1 .…”

Section: Methodsmentioning

confidence: 99%

Developmental changes in hepatic lipid metabolism of chicks during the embryonic periods and the first week of posthatch

et al. 2020

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The liver is the main site of de novo lipogenesis in poultry, and hepatic lipid metabolism disorder will lead to excessive abdominal fat deposition or fatty liver disease, finally causing huge economic loss. The present study was conducted to investigate developmental changes in hepatic lipid metabolism of chicks from embryonic periods to the first week after hatching. Liver samples were collected from embryonic day 11 ( E11 ) to the age of day 7 posthatch ( D7 ) for lipid metabolism analysis. Hematoxylin–eosin and Oil Red O staining analysis showed that hepatic lipids increased gradually during embryonic period and declined posthatch; The sum of hepatic triglycerides and cholesterol reached the peak at E19 and D1 by ELISA analysis ( P < 0.05). Acetyl-CoA carboxylase, fatty acid synthase, and acyl-CoA desaturase 1 mRNA expression in the liver were higher from E17 to D1 with the peak at E19 when compared with those at E13 and E15 ( P < 0.05). Hepatic elongase of very long-chain fatty acids 6 and microsomal triglyceride transfer protein mRNA abundance were lower during embryonic periods but reached relative higher level after hatching ( P < 0.05). On the contrary, hepatic carbohydrate response element binding protein ( ChREBP ), carnitine palmitoyltransferase 1, and peroxisome proliferators–activated receptor α expression were higher during embryonic periods but decreased posthatch ( P < 0.05). The mRNA abundance of sterol-regulatory element binding protein 1c was the lowest at E13 and E15, then increased gradually from E17 to D1, while decreased from D3 to D7 little by little ( P < 0.05). In summary, hepatic lipogenesis genes have different expression patterns during the embryonic periods and the first week of posthatch, which might be activated by ChREBP during embryonic periods; fatty acid oxidation was enhanced around the hatched day but declined posthatch. These findings will broaden the understanding of physiological characteristics and dynamic pattern about hepatic lipid metabolism in chicks.

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“…Dendritic cells are used to study the effects of LBPs, and results have shown that LBPs can induce the phenotypic and functional maturation of DCs via Notch signaling and promote the cytotoxicity of DC-mediated CTLs [80]. In nutritive additives, LBPs can be used as an additive in the growth of broilers, indicating that LBPs may possess the clinical efficacy for growth promotion and immunomodulation and can be used as an alternative to nutritive additive in broilers [81]. The nanoliposome technique is used to load LBPs and study their function, showing that LBPs can significantly promote splenocyte proliferation, increase the amount of CD4(+) to CD8(+) T cells, and promote the cytokine secretion of macrophages [82].…”

Section: Biological Function Of Lbpsmentioning

confidence: 99%

Extraction, Structural Characterization, and Biological Functions of Lycium Barbarum Polysaccharides: A Review

et al. 2019

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Lycium barbarum polysaccharides (LBPs), as bioactive compounds extracted from L. barbarum L. fruit, have been widely explored for their potential health properties. The extraction and structural characterization methods of LBPs were reviewed to accurately understand the extraction method and structural and biological functions of LBPs. An overview of the biological functions of LBPs, such as antioxidant function, antitumor activity, neuroprotective effects, immune regulating function, and other functions, were summarized. This review provides an overview of LBPs and a theoretical basis for further studying and extending the applications of LBPs in the fields of medicine and food.

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Effect of dietary Lycium barbarum polysaccharide on growth performance and immune function of broilers

Cited by 26 publications

References 33 publications

Effects of fermented Chinese herbal medicines on milk performance and immune function in late-lactation cows under heat stress conditions

Effects of fermented Chinese herbal medicines on milk performance and immune function in late-lactation cows under heat stress conditions

Developmental changes in hepatic lipid metabolism of chicks during the embryonic periods and the first week of posthatch

Extraction, Structural Characterization, and Biological Functions of Lycium Barbarum Polysaccharides: A Review

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