Effect of Dietary Intake on Urinary Oxalate Excretion in Calcium Oxalate Stone Formers in Their Forties

Naya, Yukio; Itô, Haruo; Masai, Motoyuki; Yamaguchi, Kazuyou

doi:10.1159/000020130

Cited by 11 publications

(5 citation statements)

References 20 publications

(18 reference statements)

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“…Thus, one explanation for the contradicting effects of dietary protein on the urinary Ox concentration and excretion reported in human subjects and cats could be the variation in the fat concentrations of the experimental diets. This hypothesis is supported by findings in human subjects, where a high dietary fat intake has been identified to increase renal Ox excretion ( 4 , 5 ) .…”

supporting

confidence: 61%

Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats

Paßlack

Burmeier

Brenten³

et al. 2014

J. nutr. sci.

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The role of dietary protein for the development of feline calcium oxalate (CaOx) uroliths has not been conclusively clarified. The present study evaluated the effects of a varying dietary protein concentration and quality on critical indices for the formation of CaOx uroliths. Three diets with a high protein quality (10–11 % greaves meal/diet) and a varying crude protein (CP) concentration (35, 44 and 57 % in DM) were compared. Additionally, the 57 % CP diet was compared with a fourth diet that had a similar CP concentration (55 % in DM), but a lower protein quality (34 % greaves meal/diet). The Ca and oxalate (Ox) concentrations were similar in all diets. A group of eight cats received the same diet at the same time. Each feeding period was divided into a 21 d adaptation period and a 7 d sampling period to collect urine. There were increases in urinary volume, urinary Ca concentrations, renal Ca and Ox excretion and urinary relative supersaturation (RSS) with CaOx with increasing dietary protein concentrations. Urinary pH ranged between 6·34 and 6·66 among all groups, with no unidirectional effect of dietary protein. Lower renal Ca excretion was observed when feeding the diet with the lower protein quality, however, the underlying mechanism needs further evaluation. In conclusion, although the observed higher urinary volume is beneficial, the increase in urinary Ca concentrations, renal Ca and Ox excretion and urinary RSS CaOx associated with a high-protein diet may be critical for the development of CaOx uroliths in cats.

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supporting

confidence: 61%

Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats

Paßlack

Burmeier

Brenten³

et al. 2014

J. nutr. sci.

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“…These findings contradict many studies which have put forward that increased calcium intake reduced oxaluria [3,30,31]. We thought that it was true only when the basal diet was rich in oxalate.…”

Section: Discussioncontrasting

confidence: 73%

Effect of Hyperprotidic Diet Associated or Not with Hypercalcic Diet on Calcium Oxalate Stone Formation in Rat

Sakly¹,

Bardaoui²,

Neffati³

et al. 2005

Ann Nutr Metab

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The aim of this study was to determine whether protein, administered alone or simultaneously with a hypercalcic diet, was able to aggravate calcium oxalate stone formation in rats. Thirty-two male Wistar rats were randomly divided into four groups of 8 rats each and assigned a calcium oxalate lithogenic diet added to their drinking water for 3 weeks. One group, used as reference, received a standard diet prepared in our laboratory. The second was assigned the same diet but supplemented with 7.5 g animal proteins/100 g diet. The third received a diet containing 500 mg calcium more than the standard group. The diet given to the last group was supplemented with calcium and protein at the same doses indicated previously. One day before the end of treatment, each animal was placed in a metabolic cage to collect 24-hour urine samples and determine urinary creatinine, urea, calcium, magnesium, phosphate, uric acid, citric acid and oxalate levels. Immediately thereafter, aortic blood was collected to determine the same parameters as in urine. The kidneys were also removed to determine calcium oxalate deposits. Our results showed an increased 24-hour urinary excretion of calcium, oxalate and uric acid and decreased urinary citric acid excretion only in groups that received protein supplementation. At the same time, calcium oxalate deposits were found significantly higher in hyperprotidic diets than reference or calcium-supplemented groups. According to these findings, glomerular filtration, fractional excretion of urea and reabsorption of water, calcium and magnesium were found significantly lower in hyperprotidic diets compared to other groups. These results demonstrate that proteins could seriously aggravate calcium oxalate stones and cause renal disturbances.

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“…Al Zahrani et al [6] reported the possibility of a more important role for dietary fat in stone formation than has previously been recognized. Previously [7], using multivariate analysis, we found that the intake of animal fat (but not carbohydrate or protein) correlated with urinary oxalate excretion. Animal fat contains several fatty acids and we thus determined which were strongly associated with urinary oxalate excretion and hence with calcium oxalate stones; the aim of this study was to investigate relationships between dietary fatty acids and urinary oxalate excretion in men in their fourth decade (born after 1945).…”

Section: Introductionmentioning

confidence: 84%

Association of dietary fatty acids with urinary oxalate excretion in calcium oxalate stone‐formers in their fourth decade

et al. 2002

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Objective To examine the influence of the dietary intake of fatty acid on urinary oxalate excretion in calcium oxalate stone-formers in their fourth decade, as previous reports show that animal fat intake is associated with urinary oxalate excretion. Patients and methods The dietary intake of 58 idiopathic stone-formers in their fourth decade was recorded using the dietary-record method. The patients collected 24-h urine samples at home and their urinary oxalate excretion was measured in a clinical biochemistry laboratory. The results were used to determine the relationship between the dietary intake of fatty acids and urinary oxalate excretion. Associations between urinary oxalate excretion and dietary contents of animal fat, animal protein and various fatty acids were assessed using Spearman's correlation coefficient and multiple regression. Results The dietary content of arachidonic acid was positively correlated with urinary oxalate excretion, as assessed by univariate and multivariate analysis. Conclusion The association between arachidonic acid and oxalate excretion suggests that arachidonic acid increases the intestinal absorption of oxalate and increases the clearance of oxalate in the kidneys.

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Effect of Dietary Intake on Urinary Oxalate Excretion in Calcium Oxalate Stone Formers in Their Forties

Cited by 11 publications

References 20 publications

Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats

Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats

Effect of Hyperprotidic Diet Associated or Not with Hypercalcic Diet on Calcium Oxalate Stone Formation in Rat

Association of dietary fatty acids with urinary oxalate excretion in calcium oxalate stone‐formers in their fourth decade

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