Effect of dietary fish and exercise training on urinary F2-isoprostane excretion in non—insulin-dependent diabetic patients

Mori, Trevor A.; Dunstan, David W.; Burke, Valerie; Croft, Kevin D.; Rivera, Jennifer; Beilin, Lawrence J.; Puddey, Ian B.

doi:10.1016/s0026-0495(99)90150-6

Cited by 104 publications

(70 citation statements)

References 46 publications

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“…In our study, a significant decrease was observed in TBARS after feeding n-3 PUFA to the diabetic rats and their obese offspring. These findings are substantiated by several investigators 48,49 who have reported a decreased production of TBARS in human subjects treated with DHA and EPA. In fact, endogenous antioxidant enzymes and vitamins are responsible for the detoxification of deleterious oxygen radicals.…”

Section: Fatty Acids In Diabetes and Macrosomiasupporting

confidence: 60%

N-3 Fatty acids modulate antioxidant status in diabetic rats and their macrosomic offspring

et al. 2006

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Objective: We investigated the role of dietary n-3 polyunsaturated fatty acids (n-3 PUFA) in the modulation of total antioxidant status in streptozotocin (STZ)-induced diabetic rats and their macrosomic offspring. Design: Female wistar rats, fed on control diet or n-3 PUFA diet, were rendered diabetic by administration of five mild doses of STZ on day 5 and were killed on days 12 and 21 of gestation. The macrosomic (MAC) pups were killed at the age of 60 and 90 days. Measurements: Lipid peroxidation was measured as the concentrations of plasma thiobarbituric acid reactive substances (TBARS), and the total antioxidant status was determined by measuring (i) plasma oxygen radical absorbance capacity (ORAC), (ii) plasma vitamin A, E and C concentrations, and (iii) antioxidant enzymes activities in erythrocytes. The plasma lipid concentrations and fatty acid composition were also determined. Results: Diabetes increased plasma triglyceride and cholesterol concentrations, whereas macrosomia was associated with enhanced plasma cholesterol and triglyceride levels, which diminished by feeding n-3 PUFA diet. N-3 PUFA diet also reduced increased plasma TBARS and corrected the decreased ORAC values in diabetic rats and their macrosomic offspring. EPAX diet increased the diminished vitamin A levels in diabetic mothers and vitamin C concentrations in macrosomic pups. Also, this diet improved the decreased erythrocyte superoxide dismutase and glutathione peroxidase activities in diabetic and macrosomic animals. Conclusion: Diabetes and macrosomia were associated with altered lipid metabolism, antioxidant enzyme activities and vitamin concentrations. N-3 PUFA diet improved hyperlipidemia and restored antioxidant status in diabetic dams and MAC offspring.

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Section: Fatty Acids In Diabetes and Macrosomiasupporting

confidence: 60%

N-3 Fatty acids modulate antioxidant status in diabetic rats and their macrosomic offspring

et al. 2006

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“…Higdon et al (2000) found no effect of fish oil supplementation on plasma MDA in nondiabetic subjects. Finally, plasma F 2 -isoprostanes were unaffected by fish oil supplementation in diabetic patients (Mori et al, 1999) and nondiabetics (Higdon et al, 2000). Of note is the fact that plasma TBARS, MDA, and F 2 -isoprostanes all are influenced by the availability of specific PUFAs and thus may reflect changes in concentration of specific PUFAs rather than changes in in vivo lipid peroxidation.…”

Section: Discussionmentioning

confidence: 89%

Influence of fish oil supplementation on in vivo and in vitro oxidation resistance of low-density lipoprotein in type 2 diabetes

Pedersen¹,

Petersen²,

Major‐Pedersen

et al. 2003

Eur J Clin Nutr

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“…Eventually there were 15 eligible articles, but there were several multiple publications from the same trials [53,54,55,56,57,58,59,60]. Therefore, there were actually seven trials with appropriate VO 2max data that were included in the analysis.…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in Type 2 diabetes mellitus

et al. 2003

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Aims/hypothesis. Low cardiorespiratory fitness is a powerful and independent predictor of mortality in people with diabetes. Several studies have examined the effects of exercise on cardiorespiratory fitness in Type 2 diabetic individuals. However, these studies had relatively small sample sizes and highly variable results. Therefore the aim of this study was to systematically review and quantify the effects of exercise on cardiorespiratory fitness in Type 2 diabetic individuals. Methods. MEDLINE, EMBASE, and four other databases were searched up to March 2002 for randomized, controlled trials evaluating effects of structured aerobic exercise interventions of 8 weeks or more on cardiorespiratory fitness in adults with Type 2 diabetes. Cardiorespiratory fitness was defined as maximal oxygen uptake (VO 2max ) during a maximal exercise test.Results. Seven studies, presenting data for nine randomized trials comparing exercise and control groups (overall n=266), met the inclusion criteria. Mean exercise characteristics were as follows: 3.4 sessions per week, 49 min per session for 20 weeks. Exercise intensity ranged from 50% to 75% of VO 2max . There was an 11.8% increase in VO 2max in the exercise group and a 1.0% decrease in the control group (post intervention standardized mean difference =0.53, p<0.003). Studies with higher exercise intensities tended to produce larger improvements in VO 2max . Exercise intensity predicted post-intervention weighted mean difference in HbA 1c (r=−0.91, p=0.002 Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in Type 2 diabetes mellitus N. G. Boulé 1 , G. P. Kenny 1 , E. Haddad 2 , G. A. Wells 3, 4 , R. J. Sigal 1, 3 1 School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada 2 Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada 3 Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada 4 Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada pacities of athletes. In recent decades, VO 2max has had a growing importance in clinical settings and has become the gold standard measure of cardiovascular fitness and exercise capacity [1]. There is evidence from large cohort studies that low cardiorespiratory fitness is a powerful and independent predictor of long-term cardiac mortality in people with diabetes [2,3,4], even after controlling for traditional risk factors such as age, hypercholesterolaemia, smoking, and hypertension and excluding individuals with evidence of coronary ischaemia during testing. Furthermore, in non-diabetic subjects undergoing repeated maximalThe maximal amount of oxygen consumed during exercise (VO 2max ) has been used for decades by exercise physiologists to determine the maximum exercise ca-

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Effect of dietary fish and exercise training on urinary F2-isoprostane excretion in non—insulin-dependent diabetic patients

Cited by 104 publications

References 46 publications

N-3 Fatty acids modulate antioxidant status in diabetic rats and their macrosomic offspring

N-3 Fatty acids modulate antioxidant status in diabetic rats and their macrosomic offspring

Influence of fish oil supplementation on in vivo and in vitro oxidation resistance of low-density lipoprotein in type 2 diabetes

Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in Type 2 diabetes mellitus

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