Effect of Dietary Fiber on Pancreatic Lipase Activity in Vitro

Hansen, Werner E.

doi:10.1097/00006676-198703000-00012

Cited by 46 publications

(43 citation statements)

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“…The results of this study reaffirm the idea that P. ovata husk can partially inhibit LAAD activity, as has been described with other enzymes [16][17][18]. In addition, fiber could retain some of the levodopa to make it available for absorption in more distal portions of the intestine, which would explain the final higher plasma levodopa concentrations that are observed when fiber is administered.…”

Section: Discussionsupporting

confidence: 88%

The hydrosoluble fiber Plantago ovata husk improves levodopa (with carbidopa) bioavailability after repeated administration

Diez

García

Prieto

et al. 2008

Journal of the Neurological Sciences

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The influence of treatment duration (7 or 14 days) with Plantago ovata husk/levodopa/carbidopa in the bioavailability and other pharmacokinetic parameters of levodopa were evaluated in rabbits. Fiber was administered at two different doses, 100 and 400 mg/kg, and the dosage of levodopa/carbidopa was 20:5 mg/kg. These doses were administered once a day. When 100 mg/kg of fiber was administered, the mean AUC value obtained for levodopa increased 20.2% from day 1 to day 7, and 27.2% from day 1 to day 14; C max was 8.6% higher on day 7 and 11.7% higher on day 14. When administering 400 mg/kg of fiber, the increase in AUC values was 17.6% on day 7 and 24.9% on day 14, and that of C max 11.1% on day 7 and 11.3% on day 14. The concentration determined immediately before drug administration (C min ) increased progressively with the duration of treatment, and the highest increase (53.2%) was observed on day 14 with 100 mg/kg of fiber. There was also a delay in levodopa elimination (higher MRT and lower Cl) in a fiber-dose dependent manner. In summary, we found that there was an improvement in the extent of levodopa absorbed with higher final concentrations and that levodopa elimination was slower with the administration of P. ovata husk.

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Section: Discussionsupporting

confidence: 88%

The hydrosoluble fiber Plantago ovata husk improves levodopa (with carbidopa) bioavailability after repeated administration

Diez

García

Prieto

et al. 2008

Journal of the Neurological Sciences

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“…However, when the dose of fiber is increased to 400 mg/kg, the reduction in the extent of levodopa absorbed is lower (20.4%). We think that P. ovata husk, or any product of its partial hydrolysis, could inhibit the enzyme AADC, as it has been demonstrated for other enzymes (Isaksson et al, 1982, Hansen, 1986, LengPeschlow, 1991, being this effect more important with the higher dose of fiber.…”

Section: Discussionmentioning

confidence: 72%

Hydrosoluble fiber (Plantago ovata husk) and levodopa II: Experimental study of the pharmacokinetic interaction in the presence of carbidopa

Fernández

Carriedo

Sierra

et al. 2005

European Neuropsychopharmacology

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Levodopa combined with carbidopa constitutes one of the most frequent medication in the treatment of Parkinson's disease. Plantago ovata husk (water-soluble fiber) improves levodopa absorption conditions, but when this drug is administered with carbidopa, fiber could reduce its effectiveness. The purpose of this study is to investigate whether the presence of P. ovata husk modifies in rabbits the bioavailability and other pharmacokinetic parameters of levodopa (20 mg/kg) when administered by the oral route with carbidopa (5 mg/ kg). We have also studied whether pharmacokinetic modifications are fiber-dose dependent (100 and 400 mg/kg). When levodopa and carbidopa were administered with 100 mg/kg P. ovata husk, the value of AUC for levodopa diminishes 29.7% (sign, n = 6, P b 0.05) and C max 28.1% (sign, n = 6, P b 0.05) in relation to the values obtained when these drugs were administered without fiber. If the dose of fiber was 400 mg/kg, the decrease was smaller: 20.4% for AUC (no significant difference) and 24.6% for C max (sign, n = 6, P b 0.05), that may indicate an inhibitory action of AADC by the fiber or any of its partial hydrolysis products. On the other hand, since certain time on, levodopa concentrations are always higher in the groups that receive fiber: 210 min with 100 mg/kg and 150 min with 400 mg/kg. The administration of P. ovata husk with levodopa/carbidopa to patients with Parkinson disease could be beneficial and in particular in those patients who also suffer constipation due to an improvement of levodopa kinetic profile with higher final concentrations, a longer plasma half-life and lower C max .

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“…Leng-Peschlow (1989) concluded that this fiber had no effect (pepsin, trypsin, alpha-amilase) or a stimulating action (chymotrypsin, lipase, lactase). Nevertheless, Isaksson et al (1982) found that P. ovata husk affected the lipase activity, which was moderately inhibited; Hansen (1986) established that this fiber led to an inhibition of the activity of proteolytic pancreatic enzymes in vitro and Leng-Peschlow (1991) indicated that it reduced h-glucuronidase activity in rats.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, Hansen (1986) indicated that the fiber effect on proteolytic enzyme activity was proportional to fiber concentration and inversely related to enzyme level. Our results are in agreement with these observations: the extent of levodopa absorbed is higher with the higher dose of fiber administered (100 versus 400 mg/kg).…”

Section: Discussionmentioning

confidence: 99%

Hydrosoluble fiber (Plantago ovata husk) and levodopa I: Experimental study of the pharmacokinetic interaction

García¹,

Fernández²,

Carriedo³

et al. 2005

European Neuropsychopharmacology

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Fiber therapy could be used in patients with Parkinson disease to reduce the symptoms of gastrointestinal disorders; however, it could interact with levodopa reducing its effectiveness. In this experimental study we have investigated whether the presence of Plantago ovata husk (water-soluble fiber) modifies in rabbits the bioavailability and other pharmacokinetic parameters of levodopa (20 mg/kg) when administered by the oral route at the same time. We have also studied whether pharmacokinetic modifications are fiber-dose dependent (100 and 400 mg/kg). The extent of levodopa absorbed when administering 100 mg/kg of fiber (AUC = 43.4 Ag min ml À 1 ) is approximately the same as when levodopa is administered alone (AUC = 47.1 Ag min ml À 1 ); however, C max is lower (1.04 versus 1.43 Ag ml À 1 ). Results obtained indicate that fiber at the higher dose increases the extent of levodopa absorbed (AUC = 62.2 Ag min ml À 1 ), being the value of C max similar (1.46 Ag ml À 1 ). The value of t max increases from 10 min when levodopa is administered alone to 20 min when the animals receive fiber. On the other hand, since certain time on, levodopa concentrations are always higher in the groups that receive fiber: 60 min with 100 mg/kg fiber and 20 min with 400 mg/kg fiber. Fiber also increases the mean residence time (MRT). P. ovata husk administration with levodopa could be beneficial, not only in patients with constipation, due to: lower adverse reactions (lower values of C max ) and longer and more stable effects (higher final concentrations and more time in the body). D

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Effect of Dietary Fiber on Pancreatic Lipase Activity in Vitro

Cited by 46 publications

References 0 publications

The hydrosoluble fiber Plantago ovata husk improves levodopa (with carbidopa) bioavailability after repeated administration

The hydrosoluble fiber Plantago ovata husk improves levodopa (with carbidopa) bioavailability after repeated administration

Hydrosoluble fiber (Plantago ovata husk) and levodopa II: Experimental study of the pharmacokinetic interaction in the presence of carbidopa

Hydrosoluble fiber (Plantago ovata husk) and levodopa I: Experimental study of the pharmacokinetic interaction

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