Effect of Dietary Fiber on Bowel Mucosal Integrity and Bacterial Translocation in Burned Rats.

Abstract

SummaryThe response of the bowel mucosa to enteral formula supplemented with dietary fiber was examined in rats with 30% full thickness burns. The rats were fed a standard enteral formula without fiber or with one of two types of fiber (insoluble soy fiber or soluble guar gum fiber). Seventy-two hours after burn injury, the mesenteric lymph nodes were excised aseptically for bacterial culturing. Samples of the jejunum, ileum and cecum were also collected for histological examination. There were significantly fewer bacterial colonies in the lymph node cultures from rats given soy fiber compared to those from rats fed no fiber. In rats given soy fiber, the integrity of the bowel mucosa was maintained in the jejunum, ileum and cecum. In rats given guar gum fiber, however, the repair of mucosal erosions was observed in the jejunum and ileum as well as flattening of the cecal mucosa. These findings indicate that soy fiber is superior to guar gum fiber for maintaining bowel mucosal integrity and preventing bacterial translocation in burned rats receiving enteral feeding.

Long-Term Intake of Pea Fiber Affects Colonic Barrier Function, Bacterial and Transcriptional Profile in Pig Model

“…Moreover, in disease model such as burned rats (46), rats under extraabdominal trauma (29) or stressed by 5-fluorouracil (15), dietary fiber has been shown to alleviate the damage to intestinal barrier function through modulating sIgA secretion and normalizing bacterial translocation (29,46). Furthermore, DNA microarray technology was used to determine the potential mechanism of colon function improved by long-term intake of PF.…”

Effect of enteral nutrition of monoacetoacetin on bacterial translocation in burned rats

“…28,No. 5 results suggested that MA is used effectively in the small intestine, especially under stress.…”

“…Burned animals are often used as the stress model, and many reports of BT caused by burn injury can be found. [1][2][3][4][5] Although the exact mechanisms by which burning promotes BT are unknown, immune failure and gastrointestinal microflora disruption of the host, 2 increasing of gut permeability, 3 and mucosal barrier damage by postinjury intestinal ischemia 4 are pointed out as possible causes. BT can cause sepsis and multiple organ dysfunction syndrome (MODS).…”

Diarrhea & Constipation

“…Consequently, dietary fi bers have been added to enteral nutrition formulas to normalize bowel function. Experimental studies have shown that enteral feeding with fi ber results in better colonic mucosal trophicity and in a lower rate of bacterial translocation than does enteral feeding without fi ber [ 14 ]. The clini-cal use of dietary fi bre in patients receiving tube feed is controversial, with contradictory fi ndings [ 15 -18 ].…”