“…These diseases include tuberculosis in mice (Dubos, 1955;Hedgecock, 1955), aspergillosis in chicks (Ross and Adamson, 1961), respiratory diseases in chicks (Hopkins et al, 1963), bacterial infections in mice (Nagai et al, 1961) and Escherichia coli infections in chicks (Boyd and Edwards, 1966). These diseases include tuberculosis in mice (Dubos, 1955;Hedgecock, 1955), aspergillosis in chicks (Ross and Adamson, 1961), respiratory diseases in chicks (Hopkins et al, 1963), bacterial infections in mice (Nagai et al, 1961) and Escherichia coli infections in chicks (Boyd and Edwards, 1966).…”
“…These diseases include tuberculosis in mice (Dubos, 1955;Hedgecock, 1955), aspergillosis in chicks (Ross and Adamson, 1961), respiratory diseases in chicks (Hopkins et al, 1963), bacterial infections in mice (Nagai et al, 1961) and Escherichia coli infections in chicks (Boyd and Edwards, 1966). These diseases include tuberculosis in mice (Dubos, 1955;Hedgecock, 1955), aspergillosis in chicks (Ross and Adamson, 1961), respiratory diseases in chicks (Hopkins et al, 1963), bacterial infections in mice (Nagai et al, 1961) and Escherichia coli infections in chicks (Boyd and Edwards, 1966).…”
“…With cystic fibrosis or essential fatty acid i f deficiency, the respiratory tract becomes unusually prone to staphylococcal infection (2,4,5,7,12), and the acyl chain composition of the lipids secreted into the tract is abnormal (16,17). The essential fatty acid (linoleic) content of the tract lipids is depressed with a concomitant elevation in the oleic acid content.…”
Section: Discussionmentioning
confidence: 99%
“…In humans with cystic fibrosis (2,7,12) and animals with an essential fatty acid deficiency (4,5), the respiratory tract is unusually prone to colonization and infection by Staphylococcus aureus. With either of these conditions, the lipids that are secreted into the respiratory tract increase in their oleic and decrease in their essential fatty acid, linoleic, content (16,17).…”
mentioning
confidence: 99%
“…To explore this possibility, we assessed the ability of a laboratory strain and eight strains that had been recently isolated from human subjects to grow on nutrient agar that had been supplemented with various concentrations and proportions of oleic and linoleic acids. An in vitro system was utilized because it allowed an assessment of the effect of altered fatty acid proportions on the bacteria without interference by any effect that the fatty acids might have on the defense mechanisms of the host, as suggested by Boyd and Edwards (4). MATERIALS AND METHODS Bacterial strains.…”
The effect of supplementing nutrient substrate with various combinations of concentrations of oleic and linoleic acids on the growth of 11 strains of Staphylococcus aureus was assessed. Whereas increasing the concentration of linoleic acid by itself greatly diminished the growth of all 11 strains, concomitant increases in oleic acid greatly diminished the inhibitory effect of linoleic acid. With oleic acid in the nutrient substrate, most of the strains were induced to produce slime which surrounded the cells. Since the slime incorporated oleic but not linoleic acid, such slime production isolated the cells from direct contact with the growth inhibitor, linoleic acid.
Dept. of Agricultural Chemistry, Queen's University, Belfast and Ministry of Agriculture, N. Ireland
Two experiments are described in which varying levels of corn oil or cod liver oil were added to the diet of birds previously maintained from one day old on a low‐fat cornflour‐based diet containing 0–35% linpleic acid. All diets were fed at three different metabolisable energy (ME) intake levels, the birds being fed a weighed quantity of food daily.
Neither ME intake nor dietary corn oil or cod liver oil supplementation had any significant influence on egg size. Increasing levels of dietary ME increased the number of eggs laid, the response being very rapid and occurring within the first 28 days. Any effect of dietary com oil was exerted mainly through the size of eggs laid, although these differences in egg size were not great enough to attain statistical significance. The response to dietary corn oil was not as rapid as the response to dietary ME and no significant effect of corn oil was observed until the second 28‐day period. Dietary corn oil increased the efficiency of conversion of dietary ME to egg product but dietary cod liver oil was without effect.
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