Effect of dietary cotton stalk on nitrogen and free gossypol metabolism in sheep

Rehemujiang, Halidai; Yimamu, Aibibula; Wang, Yong Li

doi:10.5713/ajas.18.0057

Cited by 9 publications

(3 citation statements)

References 8 publications

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“…Some researchers have shown that long-term feeding of excessive amounts of nondetoxified cotton by-products (e.g., cotton leaves, cottonseed meal, and cotton stalks) to vertebrates can lead to the accumulation of free gossypol (FG) in the fed animals, causing poisoning and acute respiratory distress, anorexia, fatigue, and even death [86][87][88]. This has hindered the application of cotton stalks as fodder.…”

Section: Discussionmentioning

confidence: 99%

Transformation Capability Optimization and Product Application Potential of Proteatia brevitarsis (Coleoptera: Cetoniidae) Larvae on Cotton Stalks

Zhang

et al. 2022

Insects

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Cotton stalks (CS) are a potential agricultural biomass resource. We investigated the use of CS as a feed for Proteatia brevitarsis Lewis larvae and the resulting frass (larvae dung-sand) as a fertilizer. Based on a three-factor experiment (decomposition inoculant, fermentation duration, and cattle manure ratio), the optimal parameters for the transformation of CS using P. brevitarsis larvae were determined as 40–50% of cattle manure, the use of VT inoculant and a fermentation duration of 25–30 days. Regarding the products of the transformation, the protein content of the larval body was as high as 52.49%, and the fat content was 11.7%, which is a suitable-quality insect protein source. The organic matter content of larvae dung-sand was 54.8%, and the content of total nitrogen, phosphorus, and potassium (TNPK) was 9.04%, which is twice more than that of the organic fertilizer standard (NY525-2021, Beijing, China, TNPK ≥ 4.0%), and larvae dung-sand has the potential of fertilizer application. Therefore, CS as a feed and fertilizer based on the transformation of P. brevitarsis larvae is feasible, and it is a highly efficient way to promote the utilization of both CS and cattle manure.

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Section: Discussionmentioning

confidence: 99%

Transformation Capability Optimization and Product Application Potential of Proteatia brevitarsis (Coleoptera: Cetoniidae) Larvae on Cotton Stalks

Zhang

et al. 2022

Insects

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“…Its toxic effects have been recorded in non-ruminants and ruminants (Gadelha et al, 2014). Ruminants have however the ability to detoxify the free gossypol concentration by binding it with ruminal microbial proteins (Rehemujiang et al, 2019). But this ability is reduced when gossypol intake exceeds rumen detoxification capacity (Morgan, 2015).…”

Section: Introductionmentioning

confidence: 99%

Studies on Haematological and some Serum Biochemical Changes by Oral Administration of Gossypol from Cotton Seed Cake in Rabbits

Mahmood¹,

Khan²,

Parveen³

et al. 2022

SJA

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“…For example, when dairy cows were fed with a diet supplemented with 717 mg/kg and 951 mg/kg of free gossypol for 170 days, the pregnancy rate decreased and the incidence of abortion increased [11]. Dietary gossypol can significantly reduce body weight in sheep and cause liver cell swelling, nuclear lysis, and kidney cell necrosis [12]. Dietary gossypol also decreases blood glucose and insulin levels, increases insulin sensitivity, and improves lipid metabolism in rats with type 2 diabetes [13].…”

Section: Introductionmentioning

confidence: 99%

Lipotoxic Effects of Gossypol Acetate Supplementation on Hepatopancreas Fat Accumulation and Fatty Acid Profile in Cyprinus carpio

Nie

Zhang

Ren

et al. 2022

Aquaculture Nutrition

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Cottonseed meal is an excellent protein source with low price and abundant nutrients, but the existence of free gossypol restricts its wide application in animal feeds. To explore the toxic effects of free gossypol, the effects of gossypol acetate on the growth performance, hepatopancreatic fat accumulation, and muscle fatty acid composition of the common carp (Cyprinus carpio) were investigated in the present study. Carp were randomly divided into four groups, which were fed a diet supplemented with 0, 170, 340, and 680 mg/kg gossypol acetate, respectively. After 60 days of feeding, the gossypol residue in the tissue, growth performance, blood biochemical indices, hepatopancreas histology, fatty acid components, and expression of key genes involved in lipid metabolism pathways were measured. It was found that the concentrations of free gossypol were increased significantly in the serum, bile, and hepatopancreas of carp fed 340 mg/kg and 680 mg/kg gossypol acetate ( P < 0.05 ). Dietary gossypol acetate had a limited effect on growth performance, and high concentrations of gossypol acetate induced excessive hepatopancreatic fat deposition and hepatocyte injury in C. carpio. In addition, gossypol acetate decreased total polyunsaturated fatty acids (PUFAs) and docosahexaenoic acid in muscle. In the hepatopancreas, decreased HSL, PPARα, and CD36 may result in fat accumulation. In the muscle, decreased FADS2 may be the key reason for the decrease in PUFAs. Taken together, these findings indicated that dietary gossypol acetate can cause lipid metabolism disorders, such as hepatopancreatic damage and significant changes in tissue fatty acid profile, which are regulated by the key lipid metabolic genes in common carp.

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Effect of dietary cotton stalk on nitrogen and free gossypol metabolism in sheep

Abstract: With short-term CS administration, only a small amount of FG is retained in the body. In response to long-term or high-FS CS feeding, however, FG accumulates in, and damages, the liver and kidneys.

Cited by 9 publications

References 8 publications

Transformation Capability Optimization and Product Application Potential of Proteatia brevitarsis (Coleoptera: Cetoniidae) Larvae on Cotton Stalks

Transformation Capability Optimization and Product Application Potential of Proteatia brevitarsis (Coleoptera: Cetoniidae) Larvae on Cotton Stalks

Studies on Haematological and some Serum Biochemical Changes by Oral Administration of Gossypol from Cotton Seed Cake in Rabbits

Lipotoxic Effects of Gossypol Acetate Supplementation on Hepatopancreas Fat Accumulation and Fatty Acid Profile in Cyprinus carpio

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