Effect of Dietary Conjugated Linoleic Acid on Liver Regeneration after a Partial Hepatectomy in Rats

Hirao, Akira S.; Yamasaki, Masao; Chujo, Hitomi; Koyanagi, Nami; Kanouchi, Hiroaki; Yasuda, Shin; Matsuo, Aya; Nishida, Eri; Rikimaru, Tatsuya; Tsujita, Eiji; Shimada, Mitsuo; Maehara, Yoshihiko; Tachibana, Hirofumi; Yamada, Koji

doi:10.3177/jnsv.50.9

Cited by 9 publications

(7 citation statements)

References 16 publications

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“…45,46 On the other hand, several of the effects of the CLNA isomers may, at least in part, be the result of the derived CLA isomers. 36,44,47 Therefore, the cis-9,trans-11 CLA in the liver could be responsible for the decrease in hepatocyte proliferation, as was reported by Hirao et al 48 for a study carried out in rats.…”

Section: ■ Discussionmentioning

confidence: 94%

Effects of Pomegranate Seed Oil on Glucose and Lipid Metabolism-Related Organs in Rats Fed an Obesogenic Diet

Miranda

Aguirre

Fernández‐Quintela

et al. 2013

J. Agric. Food Chem.

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Studies conducted in mice have revealed positive effects of punicic acid (PUA). The aim of this study was to analyze the effects of PUA on fat accumulation and glycemic control in rats fed an obesogenic diet. Rats were randomly divided into two groups: control group and PUA group (diet supplemented with 0.5% PUA). No changes were observed in adipose tissue weights. The glucose tolerance test showed that the glycemic value in the PUA group had decreased significantly at the final time (120 min) (-19.3%), as had fructosamine levels (-11.1%). However, homeostasis model assessment (HOMA-IR) showed that insulin resistance did not improve. No changes were observed in the liver, skeletal muscle composition, or peroxisome proliferator-activated receptors (PPARs) activation. Low levels (mg/g tissue) of PUA (0.04 ± 0.01 in both tissues) and higher levels of cis-9,trans-11 conjugated linoleic acid (0.31 ± 0.08 in liver, 0.52 ± 0.11 in muscle) were found. PUA supplementation induced hypoplasia (-16.1%) due to the antiproliferative effect on hepatocytes. In conclusion, dietary supplementation of 0.5% PUA did not lead to decreased fat accumulation in adipose tissue, liver, or skeletal muscle, or to improved glycemic control. The hypoplasia induced in liver is a negative effect that should be considered before proposing PUA as a functional ingredient.

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Section: ■ Discussionmentioning

confidence: 94%

Effects of Pomegranate Seed Oil on Glucose and Lipid Metabolism-Related Organs in Rats Fed an Obesogenic Diet

Miranda

Aguirre

Fernández‐Quintela

et al. 2013

J. Agric. Food Chem.

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“…Glutamic oxaloacetic transaminase and glutamic pyruvic transaminase activities were not significantly different among any of the groups (Table 2). While CLA potentially attenuates liver toxicity in both fatty (Zucker) and conventional (Sprague-Dawley) rats after partial hepatectomy (21,22) , ARA tended to prevent elevation of plasma glutamic oxaloacetic transaminase levels in rats given the 1•5-5•0 % SUNTGA40S oil used in the present study (23) . Furthermore, ARA itself is not toxic to the liver, as liver weight did not change with 0•5 -5•0 % SUNTGA40S administration.…”

Section: Discussionmentioning

confidence: 64%

Arachidonic acid prevents fatty liver induced by conjugated linoleic acid in mice

Oikawa

Tsuyama

Akimoto

et al. 2008

BJN

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Conjugated linoleic acid (CLA) has anti-obesity effects, but induces fatty liver in mice. The present study investigated whether co-administration of arachidonic acid (ARA) attenuates fat accumulation in the mouse liver induced by CLA. Male mice (8 weeks old) were given diets with either no addition of dietary fat (control), 3 % linoleic acid (LA), 3 % CLA, 3 % CLA þ 1 % ARA, or 3 % CLA þ 2 % ARA for 4 weeks. The perirenal fat weight in ARA-treated groups decreased similarly as with CLA alone, when compared to control or LA. Plasma TAG concentration was significantly higher in the CLA group than in either CLA þ ARA group, while plasma cholesterol and NEFA concentrations did not vary among the groups. In contrast to visceral fat, liver weight was significantly higher in the CLA group than in the control or LA groups, and the effects of CLA were attenuated by ARA. TAG and cholesterol were markedly accumulated in the liver with dietary CLA, whereas co-administration with ARA, at either concentration, suppressed CLA-induced lipid accumulation. Liver PGE 2 was enhanced by a combination of CLA and ARA when compared with CLA alone, but PGE 1 level was not significantly different among groups. In conclusion, fatty liver induced by CLA was attenuated by co-administration with ARA, furthermore, a combination of these fatty acids maintained the anti-obese effect of CLA.

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“…Conjugated linoleic acid decreased serum triacyloglycerol and changed fatty acid composition in rat's liver [16]. Kostogrys et al (2012) do not support the notion that CLA isomer supplementations to the oil or margarine possess anti-atherosclerotic effect [14,15]. Moreover, Franczyk-Żarów et al (2015) shown, that margarine supplemented with CLA significantly increased liver weight and induced steatosis in apoE/ LDLR -/mice, but CLnA supplementation alleviated the liver steatosis and affected the expression of lipid metabolism genes [9].…”

Section: Discussionmentioning

confidence: 97%

“…Moreover, dietary t10, c12 CLA induces a severe hepatic steatosis in mice with a more muted response in other species [41]. In contrast, dietary CLA did not affect serum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) activities after a partial hepatectomy (PH) in Sprague-Dawley rats [14]. Additionally, conjugated linoleic acid supplement or foods enriched with CLA was associated with a significantly increased circulating AST without any significant effect on alkaline phosphatase (ALP) and ALT levels in human studies [31].…”

Section: Discussionmentioning

confidence: 99%

Effect of conjugated linoleic acid and different type of dietary fat on serum lipid profile, liver enzymes activity and oxidative stress markers in wistar rats

Franczyk-Żarów

Kuś

Kostogrys

2018

Rocz Panstw Zakl Hig

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Background. Nutritional recommendations emphasize the need to limit consumption of saturated fatty acids and to increase the intake of polyunsaturated fatty acids in the prevention of non-communicable chronic diseases, particularly cardiovascular diseases. Among the fatty acids with health-related effects on the body, conjugated fatty acids are mentioned (i.e. CLA). Objective. The current study was designed to determine the effects of conjugated linoleic acid (CLA) on serum lipid profile, glucose, liver enzymes activity (AST and ALT), malonic dialdehyde (MDA) as well as lipid hydroperoxide (LPO) concentrations in rats fed diet differing in type of dietary fat. Material and methods. Male Wistar rats were divided into six groups and fed the following diets: control AIN-93G diet contained soybean oil (O) and diets with modification of fat source: butter (B) and margarine (M). The experimental diets were supplemented with 1% of conjugated linoleic acid (O+CLA, B+CLA, M+CLA). After 21 days the blood was collected and lipid profile, glucose, liver enzymes, MDA as well as LPO were analyzed. Results. The dietary treatments had no significant effect on the body weight and liver weight of the animals. The concentrations of total cholesterol (TC) and LDL+VLDL cholesterol were unchanged. Both experimental factors (fat source and CLA) had a significant influence on the TAG and HDL levels. Margarine (M) significantly increased the TAG concentration, whereas CLA had a significant impact on the TAG reduction (M+CLA). Glucose level was significantly decreased in all groups fed diets supplemented with CLA. Serum ALT significantly increased in all CLA groups. Fat source had statistically significant influence on the MDA concentration. The LPO level was significantly elevated in all CLA groups. There was statistically significant interaction of experimental factors (fat source and CLA supplementation) on LPO level. Conclusions. Margarine had an adverse effect on the rat’s lipid profile. However, in the group fed with margarine, the addition of CLA decreased the concentration of TAG. Regardless of the type of the dietary fat, CLA supplementation increased the level of LPO in the blood serum of animals.

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Effect of Dietary Conjugated Linoleic Acid on Liver Regeneration after a Partial Hepatectomy in Rats

Cited by 9 publications

References 16 publications

Effects of Pomegranate Seed Oil on Glucose and Lipid Metabolism-Related Organs in Rats Fed an Obesogenic Diet

Effects of Pomegranate Seed Oil on Glucose and Lipid Metabolism-Related Organs in Rats Fed an Obesogenic Diet

Arachidonic acid prevents fatty liver induced by conjugated linoleic acid in mice

Effect of conjugated linoleic acid and different type of dietary fat on serum lipid profile, liver enzymes activity and oxidative stress markers in wistar rats

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