Effect of dietary components on renal inorganic phosphate (Pi) excretion induced by a Pi-depleted diet

Ohnishi, Ritsuko; Segawa, Hiroko; Ohmoto, Tomoyo; Sasaki, Shiro; Hanazaki, Ai; Mori, Ayaka; Ikuta, Kayo; Furutani, Junya; Kawakami, Eri; Tatsumi, Sawako; Hamada, Y.; Miyamoto, Ken‐ichi

doi:10.2152/jmi.61.162

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…Also, the plasma levels of the 2 main phosphaturic hormones, FGF23 and PTH, decrease to a minimum in either chronic Pi consumption or after 4 h of acute Pi deprivation ( Figure 4 ). In mice, the reduction in the plasma concentration of FGF23 in response to a low-Pi diet is slower, given that it has not been described even after 8 h. 26 Renal adaptation to a low-Pi diet in mice also requires a minimal dose of calcium, 27 an effect that could be related to PTH because, in the absence of calcium, the plasma PTH concentration increased. In the PTX rats, the plasma FGF23 concentration also increases after the acute switch from a chronic 0.1% P diet to a 1.2% P diet ( Figure 8 ), but Pi transport is not significantly altered either in the jejunum or in the kidney ( Figure 6A ).…”

Section: Discussionmentioning

confidence: 99%

Intestinal and Renal Adaptations to Changes of Dietary Phosphate Concentrations in Rat

Lucea,

Chopo-Escuin,

Guillén

et al. 2023

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We have studied the role of the intestine, kidney, and several hormones when adapting to changes in dietary P concentration. Normal and parathyroidectomized (PTX) rats were fed pH-matched diets containing 0.1%, 0.6%, and 1.2% P concentrations. 32Pi uptake was determined in jejunum and kidney cortex brush border membrane vesicles. Several hormone and ion concentrations were determined in the blood and urine of rats. Both jejunum and kidney cortex Pi transport was regulated with 5 days of chronic feeding of P diets in normal rats. Acute adaptation was determined by switching foods on day six, which was only clearly observed in the kidney cortex of normal rats, with more statistical variability in the jejunum. However, no paradoxical increase of Pi uptake in the jejunum was reproduced after the acute switch to the 1.2% P diet. Pi uptake in the jejunum was PTH-independent, but in the kidney, the chronic adaptation was reduced, and no acute dietary adaptations were observed. The NaPi2a protein was more abundant in the PTX than the sham kidneys, but contrary to the modest or absent changes in Pi uptake adaptation, the transporter was similarly regulated by dietary P, as in the sham rats. PTH and FGF23 were the only hormones regulated by all diet changes, even in fasting animals, which exhibited regulated Pi transport despite similar phosphatemia. Evidence of Pi appetite effects was also observed. In brief, our results show new characteristics of Pi adaptations, including a lack of correlation between Pi transport, NaPi2a expression, and PTH/FGF23 concentrations.

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Section: Discussionmentioning

confidence: 99%

Intestinal and Renal Adaptations to Changes of Dietary Phosphate Concentrations in Rat

Lucea,

Chopo-Escuin,

Guillén

et al. 2023

Function

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“…As such, the kidneys are major regulators of mineral homeostasis, as illustrated by the profound dysregulation of mineral metabolism during chronic kidney disease (18). Moreover, the role of the kidney becomes more dominant when intestinal calcium or phosphate absorption is suboptimal or when bone turnover is low (19,20). In the kidney, urinary calcium is mainly reabsorbed via passive paracellular transport in the proximal tubulus (PT) and the thick ascending limb of the loop of Henle (TAL), and partially by claudins which are epithelial tight junction proteins expressed along the entire nephron.…”

Section: Introductionmentioning

confidence: 99%

Androgen action on renal calcium and phosphate handling: Effects of bisphosphonate treatment and low calcium diet

Khalil

Simitsidellis

Kim

et al. 2020

Molecular and Cellular Endocrinology

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Renal calcium and phosphate handling is an important contributor to mineral homeostasis and bone health and the androgen receptor (AR) is highly expressed in the kidney. We investigated the short term effects of androgen deprivation on renal calcium and phosphate reabsorption, independent of their effects on bone. Two weeks following orchidectomy (ORX) of adult mice, bone loss occurred along with hypercalciuria, which was similarly prevented by testosterone and dihydrotestosterone supplementation. Treatment with bisphosphonates prior to ORX also inhibited hypercalciuria, indicating that the calcium flux originated from the bone. Renal calcium and phosphate transporter expression was increased post-ORX, independent of bisphosphonates. Furthermore, androgen deprivation appeared to stimulate local synthesis of 1,25(OH)2D3. When bisphosphonate-treated mice were fed a low calcium diet, bone resorption was no longer blocked and secondary hyperparathyroidism developed, which was more pronounced in ORX mice than sham-operated mice. In conclusion, this study shows that androgen deprivation increased renal calcium and phosphate transporter expression, independent of bone, and underlines the importance of adequate intestinal calcium supply in circumstances of androgen deprivation and bisphosphonate treatment.

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“…Serum phosphate in CaOx groups was significantly decreased compared to controls, while there was no difference in UP/Cr between these groups. These findings might explain the effect of PTH on renal tubules, which can cause decreased renal reabsorption of phosphate (Prie et al, 2001) or the low P-containing diet (Ohnishi et al, 2014). Although there is no difference in serum magnesium concentration, the UMg/Cr was significantly increased in CaOx dogs which may be a consequence of reduced calcium reabsorption in renal tubules (Martinez et al, 1985) or the effect of PTH (Gill et al, 1967).…”

Section: Protein Identified In Stone-free Dogs and Caox Dogs By Lc-ms/msmentioning

confidence: 94%

The urinary proteomic analysis and the vitamin d receptor polymorphisms in dogs with calcium oxalate urolithiasis

Chamsuwan

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Calcium oxalate (CaOx) urolithiasis is one of the most common stone components which frequently occurs in both humans and dogs. Hypercalciuria is one of the predisposing factors commonly found in both people and dogs with calcium urolithiasis. The genetic factors are also involved with the pathogenesis of stone formation, and the relationship between calcium handling and vitamin D receptor (VDR) polymorphisms has been demonstrated to be related to calcium urolithiasis in human populations. Moreover, some urinary proteins may be involved in the process of stone formation. The present study aimed firstly to evaluate the relationship between VDR polymorphism in dog with CaOx urolithiasis. Secondly, the urinary proteomic profile between hypercalciuric dogs with or without CaOx urolithiasis was investigated. The study was divided into two parts: part I and part II. The study in part I was divided into 2 groups, CaOx dogs (n=35) and stone-free control dogs (n=40). The blood sample was collected for determination of complete blood count, serum chemistry profiles, serum electrolytes, serum vitamin D, and DNA analysis for single nucleotide polymorphism (rs852900542 and rs851998024) of the VDR gene. The urine sample was collected for determination of electrolyte concentrations. In study part II, the urinary proteomic profiles were determined in CaOx stone dogs with hypercalciuria (n=7) compared with the breed, age-, and sex-matched hypercalciuric controls (n=7). The results from the study in part I showed that the genotypic distribution of rs852900542 was significantly different between CaOx stone and control dogs (P<0.05), and dogs with a CC or CT genotypes had an increased risk for CaOx stones than those with the TT genotype (OR = 3.82, 95% CI 1.04 13.98, P<0.05). Moreover, CaOx dogs with CC or CT had higher UCa/Cr and UMg/Cr than those with the TT (P<0.05). However, there was no difference in genotypic distribution of rs851998024 between CaOx dogs and control dogs in this study. In the study part II, 49 proteins were identified in urine from both hypercalciuric CaOx stone former and stone-free dogs. Thrombomodulin was significantly higher between the control and case groups (P<0.05). The vesicular integral-membrane protein (VIP) 36 and pantetheinase were higher in CaOx stone-former (P=0.16 and P=0.17, respectively), while intercellular adhesion molecule 1�was reduced (P=0.14). In conclusion, the rs852900542 VDR polymorphism is associated with CaOx susceptibility in dogs, which is related to urinary calcium excretion. In addition, the hypercalciuric CaOx dogs have an increased level of urinary proteins, including thrombomodulin, pantetheinase ,and VIP36 which indicate the urinary tract injury. This genetic finding might be useful for screening dogs that are at increased risk and prevention of CaOx urolithiasis, and the identification of urinary proteins may be useful for the urinary tract injury marker in dogs with CaOx urolithiasis.

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Effect of dietary components on renal inorganic phosphate (Pi) excretion induced by a Pi-depleted diet

Cited by 3 publications

References 41 publications

Intestinal and Renal Adaptations to Changes of Dietary Phosphate Concentrations in Rat

Intestinal and Renal Adaptations to Changes of Dietary Phosphate Concentrations in Rat

Androgen action on renal calcium and phosphate handling: Effects of bisphosphonate treatment and low calcium diet

The urinary proteomic analysis and the vitamin d receptor polymorphisms in dogs with calcium oxalate urolithiasis

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