Effect of dietary carob (<i>Ceratonia siliqua</i>) syrup on blood parameters, gene expression responses and ammonia resistance in tilapia (<i>Oreochromis niloticus</i>)

Yılmaz, Ebru

doi:10.1111/are.14540

Cited by 23 publications

(12 citation statements)

References 59 publications

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“…Commercial pods syrup was supplemented to fi sh (Tilapia, Oreochromis niloticus) as part of meals that contained fi xed amounts of other food ingredients. Carob syrup had clear positive effect on immune biomarkers [90].…”

Section: Immune Systemmentioning

confidence: 94%

“…Commercial pods syrup was supplemented to fi sh (Tilapia, Oreochromis niloticus) as part of meals that contained fi xed amounts of other food ingredients. Carob syrup lowered the concentrations of superoxide dismutase [90]. Ethanolic extract of ripe seeds was prepared and it's capacity was tested with DPPH, ABTS, FRAP and CUPRAC methods [91].…”

Section: Antioxidantmentioning

confidence: 99%

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Carob Antioxidants in Human Health: From Traditional Uses to Modern Pharmacology

Azab¹

2022

J Biomed Res Environ Sci

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Carob has been used by humans since antiquity. Its major use is food, but traditional medicines of many nations used it for treatments of various health disorders. The fruits (pods or kibbles) were the main source for nutrition and medicinal uses, but decoctions and extracts were prepared from other parts of the tree, especially leaves. Modern science has analyzed most of the chemical compositions of the different parts, and among the phytochemicals that were found, antioxidants play very important roles in Carob nutritional and medicinal activities. So, in addition to having strong antioxidant activity and due to it, these natural products, their extracts, and foods that contain them, have anticancer, neuroprotective, hepatoprotective, antiaging, skin care, antidiabetic, and others. Phenolics and carbohydrates are the strongest antioxidants, but some volatile compounds have the same activity, to some extent. However, this review will present Carob antioxidants, their major nutritional and medicinal activities, and suggest future horizons for their use in human wellbeing.

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Section: Immune Systemmentioning

confidence: 94%

Section: Antioxidantmentioning

confidence: 99%

Carob Antioxidants in Human Health: From Traditional Uses to Modern Pharmacology

Azab¹

2022

J Biomed Res Environ Sci

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“…The main nutrients in complementary food items were added into the complex system of OPFRs and JTR protein and the competitive combination of nutrients and OPFRs molecules was used to restrict or reduce the human health risks of OPFRs. Various supplements have been used in the past to improve the toxicity risks of biological receptors exposed to contaminants (Zhang et al 2018;Rajabiesterabadi et al 2020;Yilmaz, 2020). The binding of OPFRs molecules to JTR in the special population was a key step in its joint neurotoxicity, reproductive toxicity, and ED toxicity (Chen et al 2015;Sun et al 2016;Baldwin et al 2017;Gu et al 2018).…”

Section: Screening Of Cfss Based On MD Simulations To Regulate Human Health Risks In Pregnant Womenmentioning

confidence: 99%

“…Abdel-Tawwab et al 2018;Hamed and Abdel-Tawwab, 2017;Hoseini et al 2018aHoseini et al , 2018b.Hoseini et al found that myrcene or menthol inclusive diet inhibited ammonia-induced tissue damage, anemia, and oxidative stress responses in common carps(Hoseini et al 2019). Also, plant supplements such as garlic(Yousefi et al 2020), artemisia annulis(Taheri Mirghaed et al 2020), olea europea(Rajabiesterabadi et al 2020), ceratonia silique(Yilmaz, 2020), phytochemicals such as 1, 8 cineole(Taheri Mirghaed et al 2019), myrcene(Hoseini et al 2019), menthol(Hoseini et al 2019), and berberine) helped biological receptors exposed to a variety of toxic substances to resist their biotoxicity. The results of these studies supported our observations and were consistent with the efficacy of plant supplements used in this study.Place Fig.2here3.2.2 Recommendation of CFS based on Taguchi experimental design to improve human health risks in special populationMD results showed that milk (A), egg (B), orange (C), spinach (D), grape (E), jujube (F), apple (G), and kiwi fruit (H) could significantly reduce the joint toxicity of OPFRs molecules (TCEP, TPHP, and TDCPP) in special population.…”

mentioning

confidence: 99%

Human Health Risk Regulation of Reproductive Toxicity, Neurotoxicity, and Endocrine Disruption in Special Populations Exposed to Organophosphorus Flame Retardants

Yang

Zhao

2021

Expo Health

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In this study, the joint toxicological characteristics of reproductive toxicity, neurotoxicity, and endocrine disruption (ED) by organophosphorus flame retardants (OPFRs) were regulated by process control. Molecular docking technology, molecular dynamics (MD), 2D-QSAR model, and density functional theory (DFT) were used to develop a health risk regulation scheme for special population such as pregnant women exposed to OPFRs. It was found that MD simulations confirmed the effectiveness of the recommended complementary food scheme (CFS) for the pregnant women with low health risk. When β-lactoglobulin, α-lactoalbumin, milk fat globule membrane (MFGM) protein, ovalbumin (OVA), ovotransferrin (OVT), vitamin, plant pigment, apple polyphenols, and malic acid were present in the CFS, the joint toxicity of OPFRs in pregnant women were significantly decreased by 2 91.18%. The reproductive toxicity played a dominant role in the joint toxicity and could be reduced by 82.48% under the recommended CFS. There was a competitive relationship between the nutrients in the recommended CFS and OPFRs binding to the joint toxic receptor (JTR). The former could easily occupy the target binding spot of the JTR protein, which reduced or prevented the binding of OPFRs to the JTR. In addition, simulation of OPFRs molecular metabolic pathways in pregnant women under the recommended CFS showed that the binding affinity between OPFRs and six metabolic kinases in pregnant women was significantly decreased (-28.85% --87.54%), indicating that the inhibition effect of OPFRs on normal biochemical reactions in the human body was significantly reduced, which to a certain extent verified the effectiveness of the recommended CFS.

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mentioning

confidence: 99%

Human Health Risk Regulation of Reproductive Toxicity, Neurotoxicity, and Endocrine Disruption in Special Populations Exposed to Organophosphorus Flame Retardants

Yang

Zhao

Liu

2021

Preprint

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In this study, the joint toxicological characteristics of reproductive toxicity, neurotoxicity, and endocrine disruption (ED) by organophosphorus flame retardants (OPFRs) were regulated by process control. Molecular docking technology, molecular dynamics (MD), 2D-QSAR model, and density functional theory (DFT) were used to develop a health risk regulation scheme for special population such as pregnant women exposed to OPFRs. It was found that MD simulations confirmed the effectiveness of the recommended complementary food scheme (CFS) for the pregnant women with low health risk. When β-lactoglobulin, α-lactoalbumin, milk fat globule membrane (MFGM) protein, ovalbumin (OVA), ovotransferrin (OVT), vitamin, plant pigment, apple polyphenols, and malic acid were present in the CFS, the joint toxicity of OPFRs in pregnant women were significantly decreased by 91.18%. The reproductive toxicity played a dominant role in the joint toxicity and could be reduced by 82.48% under the recommended CFS. There was a competitive relationship between the nutrients in the recommended CFS and OPFRs binding to the joint toxic receptor (JTR). The former could easily occupy the target binding spot of the JTR protein, which reduced or prevented the binding of OPFRs to the JTR. In addition, simulation of OPFRs molecular metabolic pathways in pregnant women under the recommended CFS showed that the binding affinity between OPFRs and six metabolic kinases in pregnant women was significantly decreased (–28.85% -–87.54%), indicating that the inhibition effect of OPFRs on normal biochemical reactions in the human body was significantly reduced, which to a certain extent verified the effectiveness of the recommended CFS.

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Effect of dietary carob (Ceratonia siliqua) syrup on blood parameters, gene expression responses and ammonia resistance in tilapia (Oreochromis niloticus)

Cited by 23 publications

References 59 publications

Carob Antioxidants in Human Health: From Traditional Uses to Modern Pharmacology

Carob Antioxidants in Human Health: From Traditional Uses to Modern Pharmacology

Human Health Risk Regulation of Reproductive Toxicity, Neurotoxicity, and Endocrine Disruption in Special Populations Exposed to Organophosphorus Flame Retardants

Human Health Risk Regulation of Reproductive Toxicity, Neurotoxicity, and Endocrine Disruption in Special Populations Exposed to Organophosphorus Flame Retardants

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