Effect of dietary calcium on renal prostaglandins

Katayama, Shigehiro; Maruno, Yoshiko; Itabashi, Akira; Inaba, Masaaki; Akabane, Shigeki; Tanaka, Kiyoshi; Shibuya, Mayumi; Kawazu, Shoji; Ishii, Jun; Kusuhara, Ryoko; Wakabayashi, T.; Kagawa, Yasuo

doi:10.1016/0952-3278(91)90158-2

Cited by 3 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This relationship may explain the significant down‐regulation of 15d‐PGJ 2 synthesis and the subsequent decrease in PPARγ expression in breast cancer. It may be relevant here to mention that the ratio of PGE 2 :15d‐PGJ 2 was 6 in the control tissue (1,000 in tumors), which is comparable to a urinary ratio of 10 between derivatives of PGD 2 46 and PGE 2 47 in healthy women.…”

Section: Discussionmentioning

confidence: 99%

Expression of cyclooxygenase‐2 and peroxisome proliferator‐activated receptor‐γ and levels of prostaglandin E₂ and 15‐deoxy‐Δ^12,14‐prostaglandin J₂ in human breast cancer and metastasis

Badawi

Badr

2002

Intl Journal of Cancer

View full text Add to dashboard Cite

Cyclooxygenase-2 (COX-2) expression and peroxisome proliferator-activated receptor-␥ (PPAR␥) inactivation are linked to increased risk of human breast cancer. The purpose of our study was to examine the relationship between COX-2 (with the resulting prostaglandins E 2 , PGE 2 ) and PPAR␥ (and its natural endogenous ligand 15-Deoxy-⌬ 12,14 -prostaglandin J 2 , 15d-PGJ 2 ) at various stages during the development of human breast cancer and its progression to metastasis. Human breast tissue specimens were collected from normal breasts or from individuals with fibrocystic disease and served as controls (n ‫؍‬ 22). Tissues were also collected from uninvolved (n ‫؍‬ 25), tumor (n ‫؍‬ 25) and lymph node metastasis (n ‫؍‬ 15) regions from breast cancer patients. COX-2 and PPAR␥ mRNA expression were increased and downregulated, respectively, in tissues from cancer patients compared to controls. Metastatic tissues tended to have higher alterations compared to non-metastatic tissues (p < 0.05). These altered expressions in COX-2 and PPAR␥ were paralleled by increases in the tissue levels of PGE 2 and decreases in 15d-PGJ 2 . A significant inverse correlation was found between PGE 2 and 15-d-PGJ 2 (r ‫؍‬ ؊0.51, p < 0.05). Significant correlations (p < 0.05) were also obtained between COX-2 and PPAR␥ mRNA (inverse, r ‫؍‬ ؊0.72) and between COX-2 and PGE 2 (direct, r ‫؍‬ 0.68). Increases in COX-2 mRNA expression and levels of PGE 2 and down-regulation of PPAR␥ mRNA expression and 15d-PGJ 2 levels were characterized as predictors of breast cancer risk (p < 0.05). Our results suggest that the altered expression of COX-2 and PPAR␥ and the subsequent modulation in the tissue levels of PGE 2 and 15-d-PGJ 2 may influence the development of human breast cancer and its progression to metastasis. © 2002 Wiley-Liss, Inc. Key words: breast cancer; cyclooxygenases; peroxisome proliferatoractivated receptors; chemopreventionThe high prevalence of breast cancer 1 and the limited options for treatment provide a strong rationale for identifying new, selective molecular targets that can be nutritionally or pharmacologically modulated and, thereby, offer a potential for chemoprevention. Among the regulatory molecules that have been characterized as holding great promise for breast cancer prevention are cyclooxygenase-2 (COX-2) and peroxisome proliferator-activated receptor-␥ (PPAR␥). 2 Cyclooxygenase is the rate-limiting enzyme in prostaglandin (PG) synthesis, of which 2 isoforms were identified: the constitutive COX-1 and the inducible COX-2. PGs produced by COX-1 mediate various physiological responses, whereas PGs produced by COX-2, predominantly PGE 2 , induce inflammation and are potent mediators of a number of signal transduction pathways that modulate cell adhesion and growth and are implicated in cancer development. 3 COX-1 and COX-2 are the primary targets of non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit the activity of these enzymes as a major mode of their anti-tumorigenic action. 4 Recent findings, however, suggest ...

show abstract

Section: Discussionmentioning

confidence: 99%

Expression of cyclooxygenase‐2 and peroxisome proliferator‐activated receptor‐γ and levels of prostaglandin E₂ and 15‐deoxy‐Δ^12,14‐prostaglandin J₂ in human breast cancer and metastasis

Badawi

Badr

2002

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

Prostaglandins and Leukotrienes

Katayama

2003

Encyclopedia of Food Sciences and Nutrition

View full text Add to dashboard Cite

Prostacyclin and thromboxane A2 production in nitric oxide-deficient hypertension in vivo. Effects of high calcium diet and angiotensin receptor blockade

Alanko

Jolma²,

Kööbi³

et al. 2003

Prostaglandins, Leukotrienes and Essential Fatty Acids

View full text Add to dashboard Cite

Effect of dietary calcium on renal prostaglandins

Cited by 3 publications

References 20 publications

Expression of cyclooxygenase‐2 and peroxisome proliferator‐activated receptor‐γ and levels of prostaglandin E₂ and 15‐deoxy‐Δ^12,14‐prostaglandin J₂ in human breast cancer and metastasis

Expression of cyclooxygenase‐2 and peroxisome proliferator‐activated receptor‐γ and levels of prostaglandin E₂ and 15‐deoxy‐Δ^12,14‐prostaglandin J₂ in human breast cancer and metastasis

Prostaglandins and Leukotrienes

Prostacyclin and thromboxane A2 production in nitric oxide-deficient hypertension in vivo. Effects of high calcium diet and angiotensin receptor blockade

Contact Info

Product

Resources

About

Effect of dietary calcium on renal prostaglandins

Cited by 3 publications

References 20 publications

Expression of cyclooxygenase‐2 and peroxisome proliferator‐activated receptor‐γ and levels of prostaglandin E2 and 15‐deoxy‐Δ12,14‐prostaglandin J2 in human breast cancer and metastasis

Expression of cyclooxygenase‐2 and peroxisome proliferator‐activated receptor‐γ and levels of prostaglandin E2 and 15‐deoxy‐Δ12,14‐prostaglandin J2 in human breast cancer and metastasis

Prostaglandins and Leukotrienes

Prostacyclin and thromboxane A2 production in nitric oxide-deficient hypertension in vivo. Effects of high calcium diet and angiotensin receptor blockade

Contact Info

Product

Resources

About

Expression of cyclooxygenase‐2 and peroxisome proliferator‐activated receptor‐γ and levels of prostaglandin E₂ and 15‐deoxy‐Δ^12,14‐prostaglandin J₂ in human breast cancer and metastasis

Expression of cyclooxygenase‐2 and peroxisome proliferator‐activated receptor‐γ and levels of prostaglandin E₂ and 15‐deoxy‐Δ^12,14‐prostaglandin J₂ in human breast cancer and metastasis