Effect of Dietary Cadmium on Iron Metabolism in Growing Rats

Crowe, Andrew; Morgan, Evan H.

doi:10.1006/taap.1997.8165

Cited by 36 publications

(17 citation statements)

References 39 publications

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“…b Feed intake was measured only for rats exposed to Cd in diet (controls were pairfed) c Cd intake of rats exposed to Cd in water and diet was calculated on the basis of the concentration of Cd in drinking water (0.3 mg Cd/l) and diet (0.4 mg Cd/kg), respectively 2002). This accounts for the use of Cd load in the liver and kidneys in the estimation of Cd uptake in the present study which is also in harmony with previous reports (Andersen et al 1992;Crowe and Morgan, 1997;Reeves and Vanderpool 1998;Lind et al 1995;Lind et al 1998). Thus the significantly (P \ 0.05) smaller combined Cd load of the liver plus that of the kidney of rats exposed to Cd via the experimental food-chain relative to those exposed to the element in drinking water for the same exposure periods (Fig.…”

Section: Discussionsupporting

confidence: 92%

Comparative effect of water and food-chain mediated cadmium exposure in rats

Asagba

2010

Biometals

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This study sets out to compare the absorption and toxicity of Cadmium (Cd) administered via the food-chain and inorganic Cd administered in drinking water after 1 and 3 months exposure using rats as animal model. The food-chain was mimicked by exposing rats to diet containing Cd pre-exposed fish. The uptake of Cd by the rats after both mode of exposure was calculated by summing up the Cd burden in the liver and kidneys and was expressed in terms of % intake. The toxicity of Cd was assessed by monitoring biochemical indices of liver function in the plasma and liver. Regardless of the mode of exposure of the rats, the Cd load in the liver and kidney was significantly (P < 0.05) higher than the respective controls with the kidney having a significantly higher load than the liver after both periods of exposure. However irrespective of the mode of exposure, more Cd was accumulated in the liver and kidney of the 3 months exposed rats relative to those exposed for 1 month. The uptake of Cd by rats exposed to Cd via the food-chain for 1 and 3 months was significantly (P< 0.05) lower when compared to the corresponding water mediated Cd exposed rats, except for the liver after 3 months of exposure. The liver L-ALT activity of rats administered inorganic Cd in drinking water for 1 and 3 months was significantly (P < 0.05) lower as compared to controls. Parallel analysis of the plasma showed no significant (P > 0.05) difference in L-ALT activity between both groups after the same periods of exposure. The L-AST activity in the plasma of rats similarly exposed to Cd for 1 and 3 months was significantly (P < 0.05) higher as compared to controls with a corresponding reduction in the liver. Conversely no significant (P > 0.05) change was observed in plasma and liver L-ALT and L-AST activities after food-chain mediated exposure to Cd for 1 and 3 months in relation to their respective controls. These findings indicate that Cd incorporated in fish is more easily bioavailable, but less toxic relative to inorganic Cd salts at the end of 3 months of exposure in rats.

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Section: Discussionsupporting

confidence: 92%

Comparative effect of water and food-chain mediated cadmium exposure in rats

Asagba

2010

Biometals

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“…The reason for the consistent lack of a detectable level of cadmium in the brain cannot be offered with certainty. However, a possible reason is that the blood-brain barrier restricts the entry of cadmium into the brain (Crowe and Morgan 1997).…”

Section: Discussionmentioning

confidence: 99%

Bioaccumulation of cadmium and its biochemical effect on selected tissues of the catfish (Clarias gariepinus)

Asagba

Eriyamremu

Igberaese

2007

Fish Physiol Biochem

120

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The present study examines the pattern of accumulation of cadmium (Cd) and its biochemical effects on selected tissues of a variety of African catfish (Clarias gariepinus), after exposure to various doses of Cd. The results obtained indicate that at the end of 21 days of exposure, the total tissue organ cadmium concentration followed the pattern kidney > gill > liver > muscle for each of the exposure concentrations. The levels of Cd in these organs were higher than those in ambient water. Moreover, while the rate of uptake of Cd increased with time in the kidney, liver and muscle, it decreased in the gill. Superoxide dismutase (SOD) was significantly elevated only in the kidney of catfish treated with 0.2 and 0.4 ppm of Cd for 7 days compared with the control. Conversely, gill SOD was significantly decreased in the same concentrations of Cd-treated catfish relative to the control. Statistically similar levels of SOD were observed in the liver, brain and muscle with all the treatments after the same duration of treatment. In the fish exposed for 21 days, SOD activity was significantly decreased in the kidney with a corresponding increase in lipid peroxidation (LPO), but it manifested only with the 0.2- and 0.4-ppm Cd treatment relative to the control. In the liver, however, Cd exposure significantly increased SOD in the 0.2- and 0.4-ppm treatments of the same duration. In conclusion, the present study indicates that the accumulation of Cd and its effect on SOD and LPO in C. gariepinus is dependent on concentration, tissue and time.

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“…In this study, a significant lower body weight of pups of animals intoxicated with cadmium was observed. Reduced pup weight was also observed in rats by Crowe & Morgan (1997), and in newborn lambs by Floris et al (2000). The decrease in birth weight could be due to a deficit in iron and/or zinc in cadmium-contaminated dams.…”

Section: Discussionmentioning

confidence: 75%

Histopathological Changes in Incisive Teeth of the Newborn Pups of Cadmium-Applied Female Rats during Pregnancy

Deveci

2010

Int. J. Morphol.

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Effect of Dietary Cadmium on Iron Metabolism in Growing Rats

Cited by 36 publications

References 39 publications

Comparative effect of water and food-chain mediated cadmium exposure in rats

Comparative effect of water and food-chain mediated cadmium exposure in rats

Bioaccumulation of cadmium and its biochemical effect on selected tissues of the catfish (Clarias gariepinus)

Histopathological Changes in Incisive Teeth of the Newborn Pups of Cadmium-Applied Female Rats during Pregnancy

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