Effect of dietary boron on the aging process.

Massie, Harold R.

doi:10.1289/ehp.94102s745

Cited by 8 publications

(6 citation statements)

References 14 publications

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“…In our study, in the experimental group, on the fifth and sixth days, congestion in the oral and nasal mucosa, yellowish color change in the nape hair and a change in body posture in the form of hunching were observed, and these findings increased significantly on the seventh day. These signs and symptoms were interpreted by Massie [22] as premature aging.…”

Section: Discussionmentioning

confidence: 99%

Histopathological Changes on Testes, Liver, Kidney and Brain Tissues in Acute Boric Acid Administration

Ayranci

Ozelmas²,

Ayrancı

2021

JPRI

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Introduction: In recent years as a result of the observation that the toxic effects of boron and its products have increased intensive studies have been initiated in our country and in the world regarding its effects, especially in the central nervous system, digestive system and reproductive system. The aim was to determine the histopathological changes caused by boric acid in rat testis, liver, kidney and brain tissues by light microscopy after oral administration of toxic dose of acute boric acid. Material and Methods: In the study, 1000 mg/kg/day boric acid was given orally for 7 days to 12-week-old 30 male albino SpragueDawley rats in total with an average weight of 285 g. Twelve male albino Sprague-Dawley rats of approximately the same weight and age were used as controls. At the end of the seventh day testes, liver, kidney and brain tissues were isolated from the animals. Results: At the end of the experiment, it was determined that the experimental group had significant body weight loss compared to the control group. Likewise, testicular, liver and kidney weights of the experimental group were decreased compared to the controls. In the histopathological examination performed with light microscopy in the testis, liver, kidney and brain tissues taken, congestion in the vascular bed of the testicular tissue and cellular degeneration at different rates were observed in paraffin sections and semi-thin sections. Conclusion: It was observed that acute boric acid administration, together with its widespread toxic effect, caused histopathological changes by inhibiting spermatogenesis, especially in testicular tissue.

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Section: Discussionmentioning

confidence: 99%

Histopathological Changes on Testes, Liver, Kidney and Brain Tissues in Acute Boric Acid Administration

Ayranci

Ozelmas²,

Ayrancı

2021

JPRI

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“…Both apples and chicken eggs have the highest concentration of B in the peels and shells, respectively, which are exposed to the environment. This could suggest that another biological role of B may be related to some protective function (protein turnover) [ 106 ].…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

The Fructoborates: Part of a Family of Naturally Occurring Sugar–Borate Complexes—Biochemistry, Physiology, and Impact on Human Health: a Review

Hunter

Nemzer

Rangavajla

et al. 2018

Biol Trace Elem Res

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Sugar–borates (SBs) are mono- or di-sugar–borate esters (SBEs) comprised of one or two monosaccharide molecules linked to a boron (B) atom. SBEs occur naturally in commonly consumed herbs, vegetables, fruits, seeds, and nuts and, other than greatly varying levels of B found in local drinking water, are the primary natural dietary sources of B-containing molecules in humans. To date, the most studied SBE is calcium fructoborate (CaFB). CaFB represents an important example of how organic B-containing molecules are significantly distinct from their inorganic counterparts. During these past two decades, CaFB has been researched for its physical and biochemical characteristics, safety, and clinical outcomes. Results of these researches are presented and discussed herein. CaFB has been characterized using Fourier-transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), high-performance thin-layer chromatography (HPTLC), nuclear magnetic resonance (NMR), liquid chromatography–multistage accurate mass spectrometry (LC-MSn), X-ray diffraction (XRD), Raman spectroscopy, and inductively coupled plasma (ICP) in non-biological and biological specimens. Potential health benefits of CaFB have been clinically investigated in pilot and efficacy studies demonstrating (i) significant reductions in knee discomfort and improved flexibility within 7, 14, and 90 days and (ii) significant effect on blood levels of inflammatory, cardiovascular, and other biomarkers. These studies support the use of CaFB as a dietary supplement for the management of joint discomfort. CaFB is presented here in order to illustrate how physiological benefits are imparted by distinct organic boron-containing molecules rather than solely by the element B itself. Considering recent National Health and Nutrition Examination Survey (NHANES) data reporting increases in age-related joint pain and an increasing elderly demographic, SBEs offer potential for safe, natural, and effective management of joint discomfort and improved mobility in human and animal health applications. Several of these studies may also open new opportunities for use of SBEs for health benefits beyond joint health.

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“…These include boron (Massie 1994); green tea catechin extract ), α-lipoic acid (Bauer et al 2004); resveratrol (Bauer et al 2004;Wood et al 2004), although these results could not be repeated in similar studies by others (Bass et al 2007); Rhodiola rosea root extract (Jafari et al 2007); Rosa damascena in Drosophila (Jafari et al 2008); and Vitamin E in Zaprionus paravittiger (Kakkar et al 1996). These include boron (Massie 1994); green tea catechin extract ), α-lipoic acid (Bauer et al 2004); resveratrol (Bauer et al 2004;Wood et al 2004), although these results could not be repeated in similar studies by others (Bass et al 2007); Rhodiola rosea root extract (Jafari et al 2007); Rosa damascena in Drosophila (Jafari et al 2008); and Vitamin E in Zaprionus paravittiger (Kakkar et al 1996).…”

Section: Specific Micronutrients and Lifespanmentioning

confidence: 99%

Biological Effects of Calorie Restriction: Implications for Modification of Human Aging

Spindler

2010

The Future of Aging

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Effect of dietary boron on the aging process.

Abstract: Total boron concentrations in Drosophila changed during development and aging. The highest concentration of boron was found during the egg stage, followed by a decline during the larval stages. Newly emerged flies contained 35.5 45-48 (1994).

Cited by 8 publications

References 14 publications

Histopathological Changes on Testes, Liver, Kidney and Brain Tissues in Acute Boric Acid Administration

Histopathological Changes on Testes, Liver, Kidney and Brain Tissues in Acute Boric Acid Administration

The Fructoborates: Part of a Family of Naturally Occurring Sugar–Borate Complexes—Biochemistry, Physiology, and Impact on Human Health: a Review

Biological Effects of Calorie Restriction: Implications for Modification of Human Aging

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