Effect of dietary betaine on growth performance, antioxidant capacity and lipid metabolism in blunt snout bream fed a high-fat diet

Adjoumani, Jean‐Jacques Yao; Wang, Kai-Zhou; Zhou, Man; Liu, Wenbin; Zhang, Dingdong

doi:10.1007/s10695-017-0405-9

Cited by 53 publications

(51 citation statements)

References 63 publications

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“…In aquaculture, few studies have investigated the effect of individual usage of betaine and choline supplementation on body weight, body composition and lipid‐related gene. For example, dietary supplementation of 12g/kg betaine could improve the growth performance and lipid‐related gene in blunt snout bream (Adjoumani, Wang, Zhou, Liu, & Zhang, ). Also, dietary administration of choline at 1800 mg/kg significantly upregulated the relative mRNA expression levels of apolipoprotein B‐100 and microsomal triglyceride transfer protein in blunt snout bream (Li et al, ).…”

Section: Introductionmentioning

confidence: 99%

Effect of dietary betaine and choline association on lipid metabolism in blunt snout bream fed a high‐fat diet

et al. 2019

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This study established the effects of betaine and choline association on lipid metabolism of blunt snout bream (Megalobrama amblycephala) fed high-fat diet (HFD).Fish (43.73 ± 0.13 g) were randomly distributed into 21 cages in seven groups (three replicates) and fed with control diet, HFD and HFD+ betaine and choline associated at different levels (16, 12, 8, 4 or 0 g/kg betaine and 0, 2, 4, 6 or 8 g/kg choline), designated as diet 1, diet 2, diet 3, diet 4, diet 5, diet 6 and diet 7 respectively for 8 weeks. Fish fed diet 4 obtained higher final body weight, weight gain and specific growth rate whereas feed conversion ratio showed the opposite trend compared to those fed HFD. Higher plasma levels of cholesterol, triglycerides, low-density lipoprotein tHcy and low levels of high-density lipoprotein, S-adenosylmethionine, S-adenosylhomocysteine were observed in fish fed HFD; the opposite was true for fish fed diet 4. Also, a lower liver superoxide dismutase, glutathione peroxidase activities and a higher malondialdehyde content were observed in fish fed HFD. This effect was reversed with fish fed diet 4. The transcription of Betaine-homocysteine S-methyl-transferase1, glycine N-methyltransferase and monoacylglycerol O-acyltransferase 1 were upregulated in fish fed HFD. The opposite trend was observed in fish fed diet 4. In conclusion, betaine and choline associated diets can benefit growth and lipid metabolism of blunt snout bream fed HFD. K E Y W O R D S antioxidant capacity, betaine, choline, growth performance, lipid metabolism, Megalobrama amblycephala

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Section: Introductionmentioning

confidence: 99%

Effect of dietary betaine and choline association on lipid metabolism in blunt snout bream fed a high‐fat diet

et al. 2019

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“…Such changes, which have been observed in blunt snout bream ( Megalobrama amblycephala ) ( Lu et al, 2013a ) and grass carp ( Ctenopharyngodon idella ) ( Du et al, 2006 ), are indicators of abnormal metabolism and physiological status. Excess lipid intake has been shown to cause oxidative stress and affect the immune responses and disease resistance of marbled rockfish ( Sebastiscus marmoratus ) ( Shi et al, 2013 ), turbot ( Scophthalmus maximus ) ( Jia et al, 2017 ), and blunt snout bream ( Adjoumani et al, 2017 ). Several studies have explored the mechanism of fatty liver formation in fish induced by a HFD ( Lu et al, 2013b ; Wang et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Changes in Physiological Parameters, Lipid Metabolism, and Expression of MicroRNAs in Genetically Improved Farmed Tilapia (Oreochromis niloticus) With Fatty Liver Induced by a High-Fat Diet

et al. 2018

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Tilapia is susceptible to hepatic steatosis when grown in intensive farming systems. The aim of this study was to explore the mechanism of fatty liver induced by a high-fat diet (HFD) in genetically improved farmed tilapia (GIFT, Oreochromis niloticus). Juvenile GIFT were fed with HFD or a normal-fat diet (NFD) for 60 days. Substantial fat deposition in the liver of HFD-fed GIFT on days 20, 40, and 60 was observed using hematoxylin – eosin staining and oil red O staining. The increased fat deposition was consistent with increased triglyceride (TG) and total cholesterol (TC) levels in the liver of HFD-fed GIFT. There were significant differences (P < 0.05) in serum biochemical indexes (TG, TC, low density lipoprotein-cholesterol, and insulin contents, and alanine aminotransferase activity) between GIFT fed a HFD and GIFT fed a NFD on days 20, 40, and 60. Furthermore, 60 days of a HFD significantly changed (P < 0.05) the hepatic fatty acid composition, and led to increased polyunsaturated fatty acid levels and decreased saturated fatty acid and monounsaturated fatty acid levels. Hepatic antioxidant enzyme activities increased by day 20 and then declined, which led to an increase in malondialdehyde contents in the liver of HFD-fed GIFT. Molecular analyses revealed that the microRNAs miR-122, miR-29a, and miR-145-5p were upregulated, whereas miR-34a was downregulated in HFD-fed GIFT. SCD, ELOVL6, and SRD5A2 encode three important enzymes in lipid metabolism, and were identified as potential targets of miRNAs. The transcript levels of hepatic SCD and ELOVL6 were decreased and that of hepatic SRD5A2 was increased in GIFT fed a HFD. Overall, the results of this study revealed a potential link between miRNAs and fatty liver induced by HFD, and suggest that a HFD could lead to excess fat deposition in the GIFT liver, which may disrupt hepatic lipid metabolism and reduce the antioxidant defense capacity.

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“…The gut microbiota is known to be closely related to host health, nutrition absorption, pathogen resistance and enhancement of immune responses. From the research result of Adjoumani et al (2017), it also notes that supplementation of betaine at 1.2% can improve growth performance and antioxidant capacity, as well as reduce fatty acid synthesis and enhance mitochondrial βoxidation and lipid transportation in high-fat diet-fed blunt snout bream (Megalobrama amblycephala). Thus, effectively alleviating fat accumulation in the liver by changing lipid metabolism.…”

Section: Liquid Chromatography-mass Spectrometry (Lc-ms)mentioning

confidence: 99%

Active Compounds on Squid (Loligo sp.) Ink Extract Powder as Immunostimulant Candidate to Against Shrimp Disease

Affandi

Fadjar

Ekawati

2019

RJLS

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The business of developing shrimp farming cannot be separated from the existence of disease. In shrimp farming health management, disease prevention strategies can use various methods, one of which is immunostimulant. One alternative immunostimulant source that can be used to improve the body defense system in shrimp is squid (Loligo sp.) ink extract powder who has antibacterial ability. This study aims to analyze the presence of active compound in squid ink extract powder can be used as an immunostimulant candidate against shrimp disease. The method used in this research is descriptive explorative and experimental method. This research was conducted with several stages of squid ink extraction until it becomes powder. Identification of squid ink extract powder is using FTIR and LC-MS test. The results showed that the squid ink extract powder contained alkaloid and carboxylic acid from the FTIR test results. Based on LC-MS test results, it was found that squid ink extract powder contained betaine, cinnamic acid, and choline compounds with large amounts of content. Betaine, cinnamic acid, and choline have several biological activities as antibacterial, antioxidant, antiviral, antifungal, etc. so that it can be used as an immunostimulant against shrimp disease.

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Effect of dietary betaine on growth performance, antioxidant capacity and lipid metabolism in blunt snout bream fed a high-fat diet

Cited by 53 publications

References 63 publications

Effect of dietary betaine and choline association on lipid metabolism in blunt snout bream fed a high‐fat diet

Effect of dietary betaine and choline association on lipid metabolism in blunt snout bream fed a high‐fat diet

Changes in Physiological Parameters, Lipid Metabolism, and Expression of MicroRNAs in Genetically Improved Farmed Tilapia (Oreochromis niloticus) With Fatty Liver Induced by a High-Fat Diet

Active Compounds on Squid (Loligo sp.) Ink Extract Powder as Immunostimulant Candidate to Against Shrimp Disease

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