Effect of Diet Restriction on Some Biochemical Parameters Related to Aging in Mice

Chipalkatti, S.; De, Ajit; Aiyar, A. S.

doi:10.1093/jn/113.5.944

Cited by 88 publications

(16 citation statements)

References 35 publications

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“…In calorie restriction (CR) studies, most often performed in rodents, a level of nutrients, vitamins, and minerals is provided in the diet that is comparable to ad libitum (AL) consumption, but in CR there is a reduction in calories consumed, i.e., undernutrition without malnutrition. The CR model is a reliable anti-aging intervention with numerous health benefits that enable maintenance of function during aging (Chipalkatti et al 1983;Masoro 1988;Weindruch and Walford 1988). However, its effects on wound healing have not appeared to be as beneficial (Reiser et al 1995;Roth et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Effect of calorie restriction and refeeding on skin wound healing in the rat

Hunt

Zhu

et al. 2011

AGE

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Calorie restriction (CR) is a reliable antiaging intervention that attenuates the onset of a number of age-related diseases, reduces oxidative damage, and maintains function during aging. In the current study, we assessed the effects of CR and other feeding regimens on wound healing in 7-month-old Fischer-344 rats from a larger cohort of rats that had been fed either ad libitum (AL) or 40% calorie restricted based on AL consumption. Rats were assigned to one of three diet groups that received three skin punch wounds along the dorsal interscapular region (12-mm diameter near the front limbs) of the back as follows: (1) CR (n=8) were wounded and maintained on CR until they healed, (2) AL (n=5) were wounded and maintained on AL until wound closure was completed, and (3) CR rats were refed (RF, n=9) AL for 48 h prior to wounding and maintained on AL until they healed. We observed that young rats on CR healed more slowly while CR rats refed for 48 h prior to wounding healed as fast as AL fed rats, similar to a study reported in aged CR and RF mice (Reed et al. 1996). Our data suggest that CR subjects, regardless of age, fail to heal well and that provision of increased nutrition to CR subjects prior to wounding enhances the healing process.

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Section: Introductionmentioning

confidence: 99%

Effect of calorie restriction and refeeding on skin wound healing in the rat

Hunt

Zhu

et al. 2011

AGE

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“…Indeed, the early indication that FR modifies the extent of free radical damage stems from the observation that protein restriction decreased lipofuscin accumulation in the brain and heart of mice (44). Subsequent experiments confirmed these data (45) and, in addition, demonstrated that lipid peroxidation, as measured by malondialdheyde content in liver homogenate, was reduced in FR animals, compared to the control groups (46). Further support for the modulating effect of FR on membrane lipid peroxidation was reported in subcellular membranes of liver (39,47), heart (48), and erythrocytes (27).…”

Section: Peroxidizability Of Cellular Membranesmentioning

confidence: 88%

Membrane properties and lipid peroxidation in food restricted animals

Pieri

1997

AGE

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Food restriction (FR) is a well-recognized method of extending mean and maximum longevity of rodents, but the mode of its action remains to be uncovered. This article reviews the effect of FR on the physicalchemical properties and lipid peroxidizability of cellular membranes. FR prevents the age-dependent increase in microviscosity and peroxidizability of cellular membranes. It has been suggested that a decrease in the body temperature occurring in undernourished animals may play a fundamental role in the process. Indeed, the lowering of average body temperature occurring in FR animals may induce a modification in membrane lipid composition, stimulating the cells to counteract the rigidifying effect of lower temperature. Thus, membranes are maintained in a proper functional state by a mechanism similar to that found in poikilotherm animals.

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“…Many authors consider lipid peroxidation (LPO) to be a basic mechanism leading to denaturation of the hepatic membrane structure in alcohol intoxication [2][3][4][5][6]. There are some observations that malnutrition inhibits LPO [7][8][9]. However, other data suggest that with reduced food intake the detoxification mechanisms against free radicals could be impaired, which would stimulate LPO [1014].…”

Section: Discussionmentioning

confidence: 99%

Influence of Starvation and Chronic malnutrition on Lipid Peroxidation in Rats Treated with Ethanol.

Pentieva

Adjarov

Naydenova

et al. 1993

J. Clin. Biochem. Nutr.

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SummaryThe effect of starvation and chronic food restriction on lipid peroxidation during treatment with ethanol was studied. The experiment was carried out on 64 female Wistar rats. The formation of malondialdehyde was determined in postmitochondrial liver fraction (basal level and after stimulation with ascorbate). The concentration of reduced glutathione was measured in the same fraction.In rats fed ad libitum, the consumption of ethanol, given with the drinking water for either 3 or 28 days, promoted a slight, but statistically nonsignificant, activation of lipid peroxidation. In animals not given ethanol, a 3-day fast increased the formation of lipid peroxides after stimulation with ascorbate. However, some tendency toward inhibition of lipid peroxidation was established after consumption of a restricted diet (6-8 g standard pellet food daily) for 28 days. The treatments with alcohol for 3 and 28 days were combined respectively with a 3-day fast and a 28-day food restriction. In both a statistically significant increase in lipid peroxides was observed in comparison with the controls, which were fed ad libitum and were not given ethanol.The concentration of reduced glutathione was decreased in all experimental groups, but only with the 3-day treatments did the extent of its depletion correspond to the activation of lipid peroxidation. The results show that both starvation and chronic malnutrition potentiate lipid peroxide formation in rats treated with ethanol.

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Effect of Diet Restriction on Some Biochemical Parameters Related to Aging in Mice

Cited by 88 publications

References 35 publications

Effect of calorie restriction and refeeding on skin wound healing in the rat

Effect of calorie restriction and refeeding on skin wound healing in the rat

Membrane properties and lipid peroxidation in food restricted animals

Influence of Starvation and Chronic malnutrition on Lipid Peroxidation in Rats Treated with Ethanol.

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