Effect of diet on serotonergic neurotransmission in depression

Shabbir, Faisal; Patel, Akash; Mattison, Charles; Bose, Saswata; Krishnamohan, Raathathulaksi; Sweeney, Emily A.; Sandhu, Sarina; Nel, Wynand; Rais, Afsha; Sandhu, Ranbir S.; Ngu, Nguasaah; Sharma, Sushil

doi:10.1016/j.neuint.2012.12.014

Cited by 116 publications

(84 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Diets rich in vitamin B6 and tryptophan help boost serotonergic neurotransmission in depression observed in various neurodegenerative diseases. In fact, vitamin B6 deficient rats are highly susceptible to seizure disorders [111]. In addition, 140 individuals with symptoms of depression were shown to have significantly low levels of plasma pyridoxal phosphate, the phosphate derivative of vitamin B6 [96].…”

Section: Vitamin B6 (Pyridoxine)mentioning

confidence: 99%

The Effects of Vitamin B in Depression

Mikkelsen¹,

Stojanovska²,

Apostolopoulos

2016

CMC

128

View full text Add to dashboard Cite

Abstract:Vitamins are dietary components which are necessary for life. They play a major role in health and their deficiency may be linked to symptoms of psychiatric disorders. B vitamins are required for proper functioning of the methylation cycle, monoamine oxidase production, DNA synthesis and the repair and maintenance of phospholipids. Vitamin B deficiency could influence memory function, cognitive impairment and dementia. In particular, vitamins B1, B3, B6, B9 and B12 are essential for neuronal function and deficiencies have been linked to depression. We discuss the causes of depression and the neurochemical pathways in depression. In particular, we provide evidence that vitamin B contributes to the complexity of depressive symptoms.

show abstract

Section: Vitamin B6 (Pyridoxine)mentioning

confidence: 99%

The Effects of Vitamin B in Depression

Mikkelsen¹,

Stojanovska²,

Apostolopoulos

2016

CMC

128

View full text Add to dashboard Cite

show abstract

“…The enzyme preferentially degrades benzylamine and phenylethylamine and targets a wide variety of specific neurotransmitters involved in the primary substrates of MAO in the brain, including epinephrine (EP), norepinephrine (NE), dopamine (DA), serotonin (5-HT), and β-phenylethylamine (PEA) (1,2). The unique position of MAO in modulating the function of a diverse series of specific neurotransmitters in association with various conditions, including mood disorders (3), anxiety and depression (4,5), schizophrenia (6), attention deficit hyperactivity disorder (7)(8)(9), migraine (10), sexual maturation (11) and neurodegenerative diseases (12), has attracted significant attention to the protein as a therapeutic target.…”

Section: Introductionmentioning

confidence: 99%

Monoamine oxidase inhibitors: Promising therapeutic agents for Alzheimer’s disease (Review)

Cai

2014

Molecular Medicine Reports

165

View full text Add to dashboard Cite

Abstract. Activated monoamine oxidase (MAO) has a critical role in the pathogenesis of Alzheimer's disease (AD), including the formation of amyloid plaques from amyloid β peptide (Aβ) production and accumulation, formation of neurofibrillary tangles, and cognitive impairment via the destruction of cholinergic neurons and disorder of the cholinergic system. Several studies have indicated that MAO inhibitors improve cognitive deficits and reverse Aβ pathology by modulating proteolytic cleavage of amyloid precursor protein and decreasing Aβ protein fragments. Thus, MAO inhibitors may be considered as promising therapeutic agents for AD.

show abstract

“…However, in other cases, studies found no association between dietary pattern, including CHO intake, and risk of depression (130). Dietary modifications have been found to relieve symptoms of depression in some individuals (94). Age, gender, and geographic region all have an impact on the role of CHO-and grain-based foods in the diet and symptoms of depression (106,116,125).…”

Section: Discussionmentioning

confidence: 99%

“…These neurotransmitters include dopamine, norepinephrine, g-aminobutyric acid, and serotonin (94). Low serotonin levels are implicated in the etiology of depression, and increased levels of serotonin are related to improved mood (95).…”

Section: Grains Chos Glycemic Index and Glycemic Loadmentioning

confidence: 99%

“…Low serotonin levels are implicated in the etiology of depression, and increased levels of serotonin are related to improved mood (95). Serotonin synthesis requires adequate dietary sources of tryptophan and vitamin B 6 , a coenzyme for the reactions (94)(95)(96)(97)(98). It has been theorized that serotonin synthesis occurs when an insulin-raising CHO is consumed, because insulin is needed to trigger tryptophan uptake by the brain; however, if even a small amount of protein is present, tryptophan uptake is blunted.…”

Section: Grains Chos Glycemic Index and Glycemic Loadmentioning

confidence: 99%

See 1 more Smart Citation

Full Issue PDF

2017

Cereal Foods World

View full text Add to dashboard Cite

Effect of diet on serotonergic neurotransmission in depression

Cited by 116 publications

References 60 publications

The Effects of Vitamin B in Depression

The Effects of Vitamin B in Depression

Monoamine oxidase inhibitors: Promising therapeutic agents for Alzheimer’s disease (Review)

Full Issue PDF

Contact Info

Product

Resources

About