Effect of diet on aflatoxin B1-DNA binding and aflatoxin B1-induced glutathione S-transferase placental form positive hepatic foci in the rat

Kimura, Masatomo; Lehmann, Kiyoko; Gopalan-Kriczky, Prathima; Lotlikar, Prabhakar D.

doi:10.1038/emm.2004.46

Cited by 7 publications

(6 citation statements)

References 33 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reaction was initiated by the addition of cell extract. GST activity was assayed spectrophotometrically as described (Habig et al, 1974;Kimura et al, 2004) with minor modifications. The reaction mixture contained 100 mM phosphate buffer (pH 6.5), 5.0 mM GSH, 2.0 mM CDNB, and crude extract in a vol of 1.0 ml.…”

Section: Determination Of Total Intracellular Gsh Contentmentioning

confidence: 99%

Up-regulation of defense enzymes is responsible for low reactive oxygen species in malignant prostate cancer cells

Lim

Hong²,

Jin³

et al. 2005

Exp Mol Med

View full text Add to dashboard Cite

Section: Determination Of Total Intracellular Gsh Contentmentioning

confidence: 99%

Up-regulation of defense enzymes is responsible for low reactive oxygen species in malignant prostate cancer cells

Lim

Hong²,

Jin³

et al. 2005

Exp Mol Med

View full text Add to dashboard Cite

“…Aflatoxin AFB 1 is a powerful carcinogen for human and many animal species, including rodents (Fetaiha et al, 2014), non-human primates and fish (Kimura et al, 2004;Santacroce et al, 2008). It can increase the rate of DNA adducts, histidine revertants, chromosomal aberration, mi-…”

Section: Resultsmentioning

confidence: 99%

Does Bougainvillea spectabilis protect Swiss Albino Mice from Aflatoxin-induced Hepatotoxicity?

Mishra¹,

Tandon²,

Dhama³

et al. 2016

Adv. Anim. Vet. Sci.

View full text Add to dashboard Cite

| We have investigated the protective effect of oral administration of the ethanolic extract of Bougainvillea spectabilis leaves against aflatoxin B 1 (AFB 1 ) induced hepatic injuries among male Swiss albino mice. AFB 1 exposure has significantly increased (P< 0.05) the lipid peroxidase activity and decreased the activities of various antioxidant enzymes viz. superoxide dismutase (57.58%), catalase (24.14%), glutathione peroxidase (44.21%), glutathione S-transferase (44.07%) and glutathione reductase (13.51%). It also declined the level of ascorbic acid, reduced glutathione and protein contents by 47%, 34% and 24% respectively. It markedly decreased lipid peroxidation (TBARS level) with concomitant stimulation (P < 0.05) of antioxidants (enzymatic and non -enzymatic both). HPTLC analysis revealed availability of sufficient amount of flavonoids, alkaloids and phenolic compounds in the extract of B. spectabilis leaves might be responsible for the improved efficiency of antioxidant system and subsequent protection from aflatoxicity.

show abstract

“…AFB 1 is a powerful carcinogen for humans and many animal species, including rodents, non-human primates, and fish [5,23]. The main target of this carcinogen is the liver, although tumors may also develop in other organs, such as the lungs, kidney and colon [9].…”

Section: Dna Damage By Aflatoxin B1 (Afb1)mentioning

confidence: 99%

Antigenotoxic Studies of Different Substances to Reduce the DNA Damage Induced by Aflatoxin B1 and Ochratoxin A

Madrigal-Santillán

Morales-González

Vargas-Mendoza

et al. 2010

Toxins

View full text Add to dashboard Cite

Mycotoxins are produced mainly by the mycelial structure of filamentous fungi, or more specifically, molds. These secondary metabolites are synthesized during the end of the exponential growth phase and appear to have no biochemical significance in fungal growth and development. The contamination of foods and feeds with mycotoxins is a significant problem for the adverse effects on humans, animals, and crops that result in illnesses and economic losses. The toxic effect of the ingestion of mycotoxins in humans and animals depends on a number of factors including intake levels, duration of exposure, toxin species, mechanisms of action, metabolism, and defense mechanisms. In general, the consumption of contaminated food and feed with mycotoxin induces to neurotoxic, immunosuppressive, teratogenic, mutagenic, and carcinogenic effect in humans and/or animals. The most significant mycotoxins in terms of public health and agronomic perspective include the aflatoxins, ochratoxin A (OTA), trichothecenes, fumonisins, patulin, and the ergot alkaloids. Due to the detrimental effects of these mycotoxins, several strategies have been developed in order to reduce the risk of exposure. These include the degradation, destruction, inactivation or removal of mycotoxins through chemical, physical and biological methods. However, the results obtained with these methods have not been optimal, because they may change the organoleptic characteristics and nutritional values of food. Another alternative strategy to prevent or reduce the toxic effects of mycotoxins is by applying antimutagenic agents. These substances act according to several extra- or intracellular mechanisms, their main goal being to avoid the interaction of mycotoxins with DNA; as a consequence of their action, these agents would inhibit mutagenesis and carcinogenesis. This article reviews the main strategies used to control AFB1 and ochratoxin A and contains an analysis of some antigenotoxic substances that reduce the DNA damage caused by these mycotoxins.

show abstract

Effect of diet on aflatoxin B1-DNA binding and aflatoxin B1-induced glutathione S-transferase placental form positive hepatic foci in the rat

Cited by 7 publications

References 33 publications

Up-regulation of defense enzymes is responsible for low reactive oxygen species in malignant prostate cancer cells

Up-regulation of defense enzymes is responsible for low reactive oxygen species in malignant prostate cancer cells

Does Bougainvillea spectabilis protect Swiss Albino Mice from Aflatoxin-induced Hepatotoxicity?

Antigenotoxic Studies of Different Substances to Reduce the DNA Damage Induced by Aflatoxin B1 and Ochratoxin A

Contact Info

Product

Resources

About