Effect of diet and omega-3 fatty acid intervention on asymmetric dimethylarginine

Eid, H.M.A.; Arnesen, Harald; Hjerkinn, Elsa M.; Lyberg, Torstein; Ellingsen, Ingrid; Seljeflot, Ingebjørg

doi:10.1186/1743-7075-3-4

Cited by 28 publications

(5 citation statements)

References 52 publications

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“…In our study, in response to daily supplementation with 2234 mg of EPA and 916 mg of DHA, we observed an increase in resting plasma L-arg concentration with no change in ADMA concentration. These results are in line with a previous report in non-athletes [28]. As previously mentioned, the mechanism behind this is not fully understood, although it was originally thought that omega-3 fatty acids could decrease plasma ADMA concentrations; however, the evidence for this is scarce and inconsistent.…”

Section: Discussionsupporting

confidence: 92%

Increased Plasma L-Arginine Levels and L-Arginine/ADMA Ratios after Twelve Weeks of Omega-3 Fatty Acid Supplementation in Amateur Male Endurance Runners

et al. 2022

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It is not fully understood how supplementation with omega-3 fatty acids affects the metabolism of amino acids required for the bioavailability/synthesis of NO, i.e., L-arginine (L-arg), asymmetric dimethylarginine (ADMA), their metabolites, and the L-arg/ADMA ratio and their impact on running economy (RE) in runners. Thus, 26 male amateur endurance runners completed a twelve-week study in which they were divided into two supplemented groups: the OMEGA group (n = 14; 2234 mg and 916 mg of eicosapentaenoic and docosahexaenoic acid daily) or the MCT group (n = 12; 4000 mg of medium-chain triglycerides daily). At the same time, all participants followed an endurance training program. Before and after the 12-week intervention, blood was collected from participants at two time points (at rest and immediately post-exercise) to determine EPA and DHA in red blood cells (RBCs) and plasma levels of L-arg, ADMA, and their metabolites. RBC EPA and DHA significantly increased in the OMEGA group (p < 0.001), which was related to the resting increase in L-arg (p = 0.001) and in the L-arg/ADMA ratio (p = 0.005) with no changes in the MCT group. No differences were found in post-exercise amino acid levels. A total of 12 weeks of omega-3 fatty acid supplementation at a dose of 2234 mg of EPA and 916 mg of DHA daily increased levels of L-arg and the L-arg/ADMA ratio, which indirectly indicates increased bioavailability/NO synthesis. However, these changes were not associated with improved RE in male amateur endurance runners.

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Section: Discussionsupporting

confidence: 92%

Increased Plasma L-Arginine Levels and L-Arginine/ADMA Ratios after Twelve Weeks of Omega-3 Fatty Acid Supplementation in Amateur Male Endurance Runners

et al. 2022

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“…In the study of Eid et al, the impact of omega-3 polyunsaturated fatty acid supplementation and/or MED in men with a high risk of cardiovascular disease were assessed. In this study, none of the interventions decreased ADMA concentrations (Eid et al, 2006). In our study the ADMA concentration lowered significantly after nutritional intervention in the CED group but not in the MED group.…”

Section: Discussioncontrasting

confidence: 65%

The Central European diet as an alternative to the Mediterranean diet in atherosclerosis prevention in postmenopausal obese women with a high risk of metabolic syndrome - a randomized nutrition-al trial

Duś-Żuchowska

Bajerska

Krzyżanowska

et al. 2018

Acta Sci Pol Technol Aliment

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www.food.actapol.net pISSN 1644-0730 eISSN 1898-9594 http://dx. ABSTRACTBackground. Metabolic syndrome (MS) is a powerful risk factor for atherosclerosis (AT). The crucial method of minimizing the development of atherosclerosis and its clinical manifestations is lifestyle modifications, including following a healthy diet. The aim of the study was to check if the Central European Diet (CED) could be an alternative to the Mediterranean Diet (MED) in the prevention of AT in patients with a risk of MS. Methods. The randomized, single-blind nutritional trial involved 144 obese women with a risk of MS. The subjects were randomly assigned to two groups and followed MED (n = 72) or CED (n = 72) for 16 weeks. The concentrations of high-sensitivity C-reactive protein (hs-CRP) and asymmetrical dimethylarginine (ADMA) were measured before and after nutritional intervention. Results. In both studied groups, the concentrations of hs-CRP decreased significantly after the nutritional intervention (CED: p = 0.0107; MED: p = 0.0002). The ADMA levels were significantly lower after nutritional intervention in the CED group (p = 0.0187) but not in the MED group (p = 0.8354). However, the observed changes of hs-CRP concentrations (Δhs-CRP) and ADMA levels (ΔADMA) were not different between the groups (p = 0.5307 and p = 0.0905, respectively). Conclusion. In the Central European post-menopausal obese population, a well-designed, energy-restricted diet with the use of food items traditional for the region (CED) could be a good alternative to MED in terms of AT prevention.

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“…Aliment., 17(4), 399-407. http://dx.doi.org/10.17306/J.AFS.2018.0593 www.food.actapol.net/ disease were assessed. In this study, none of the interventions decreased ADMA concentrations (Eid et al, 2006). In our study the ADMA concentration lowered significantly after nutritional intervention in the CED group but not in the MED group.…”

Section: Discussioncontrasting

confidence: 65%

The Central European diet as an alternative to the Mediterranean diet in atherosclerosis prevention in postmenopausal obese women with a high risk of metabolic syndrome - a randomized nutrition-al trial [pdf]

Duś-Żuchowska¹,

Bajerska²,

Krzyzanowska³

et al. 2018

Acta Sci Pol Technol Aliment

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Background. Metabolic syndrome (MS) is a powerful risk factor for atherosclerosis (AT). The crucial method of minimizing the development of atherosclerosis and its clinical manifestations is lifestyle modifications, including following a healthy diet. The aim of the study was to check if the Central European Diet (CED) could be an alternative to the Mediterranean Diet (MED) in the prevention of AT in patients with a risk of MS. Methods. The randomized, single-blind nutritional trial involved 144 obese women with a risk of MS. The subjects were randomly assigned to two groups and followed MED (n = 72) or CED (n = 72) for 16 weeks. The concentrations of high-sensitivity C-reactive protein (hs-CRP) and asymmetrical dimethylarginine (ADMA) were measured before and after nutritional intervention. Results. In both studied groups, the concentrations of hs-CRP decreased significantly after the nutritional intervention (CED: p = 0.0107; MED: p = 0.0002). The ADMA levels were significantly lower after nutritional intervention in the CED group (p = 0.0187) but not in the MED group (p = 0.8354). However, the observed changes of hs-CRP concentrations (Δhs-CRP) and ADMA levels (ΔADMA) were not different between the groups (p = 0.5307 and p = 0.0905, respectively). Conclusion.In the Central European post-menopausal obese population, a well-designed, energy-restricted diet with the use of food items traditional for the region (CED) could be a good alternative to MED in terms of AT prevention.

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Effect of diet and omega-3 fatty acid intervention on asymmetric dimethylarginine

Cited by 28 publications

References 52 publications

Increased Plasma L-Arginine Levels and L-Arginine/ADMA Ratios after Twelve Weeks of Omega-3 Fatty Acid Supplementation in Amateur Male Endurance Runners

Increased Plasma L-Arginine Levels and L-Arginine/ADMA Ratios after Twelve Weeks of Omega-3 Fatty Acid Supplementation in Amateur Male Endurance Runners

The Central European diet as an alternative to the Mediterranean diet in atherosclerosis prevention in postmenopausal obese women with a high risk of metabolic syndrome - a randomized nutrition-al trial

The Central European diet as an alternative to the Mediterranean diet in atherosclerosis prevention in postmenopausal obese women with a high risk of metabolic syndrome - a randomized nutrition-al trial [pdf]

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