Effect of dienogest administration on angiogenesis and hemodynamics in a rat endometrial autograft model

Abstract

DNG inhibited angiogenesis of the ectopic endometrium, with confirmed structural changes in the microvessels.

Effects ofLactobacillus gasseriOLL2809 on the Induced Endometriosis in Rats

“…by increasing the NK activity of peritoneal fluid cells and splenic cells. Moreover, Katayama et al 14) have reported the efficacy of dienogest on angiogenesis and hemodynamics in a rat endometrial autograft model that mechanically isolated endometrial fragments transplanted into dorsal skinfold chambers. Katsuki et al 6) used proestrous rats and model of autotransplantation of endometrial tissue to a renal subcapsular site, but in the present study no efficacy of dienogest was observed in the diestrus rats, although most of rat decreased as to volume of endometriosis.…”

“…We used a rat model in which the endometrium was implanted on the left abdominal wall, and dienogest was administered twice a day starting 1 week after implantation. Katayama et al 14) administered dienogest once a day from day 0 or 4 after implantation, and Katsuki et al 6) once a day from 2 weeks after implantation. The experimental models and administration protocols were different among these three experiments, although the dosages used were almost equal.…”

Progesterone Resistance and Targeting the Progesterone Receptors: A Therapeutic Approach to Endometriosis

“…Whilst the evaluation of gene ablation on eutopic and ectopic endometrial cell growth has been revealing, the studies of pharmacological modulation contrast these observations to a certain extent as both progestogens and PRAs reduce ectopic endometrial cell proliferation and disease burden in pre-clinical rodent models of endometriosis (Bruner-Tran et al, 2006;Chwalisz et al, 1998;Katayama et al, 2010;Katsuki et al, 1998;Stoeckemann et al, 1995). An explanation of this phenomenon compared with the phenotype of PRKO animals has been revealed by studies with PRAs in the non-human primate.…”

Is endometriosis a benign disease? Modern controversial aspects of endometriosis-associated ovarian tumors

“…Как производное 19-нортестостерона он характе-ризуется высокой селективностью к прогестероно-вым рецепторам, мощным прогестагенным воздей-ствием на эндометрий, благодаря чему, в отличие от других гестагенов, обладает специфическим анти-пролиферативным, антиангиогенным, проапопти-ческим и противовоспалительным свойствами и воз-действует на все звенья патогенеза эндометриоза [48][49][50][51].…”