Effect of diencephalic and rhinencephalic lesions on the male rat's sexual behavior.

Giantonio, Gerald W.; Lund, Nick L.; Gerall, Arnold A.

doi:10.1037/h0030005

Cited by 194 publications

(52 citation statements)

References 12 publications

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“…The specific deficits, i.e., longer interintromission intervals and ejaculatory latencies, were generally consistent with previous studies (Giantonio et al, 1970;Emery and Sachs, 1976;Valcourt and Sachs, 1979;Claro et al, 1995). (We interpret the reduced percentage of MPOAx males achieving ejaculation as being secondary to changes in these measures in the face of time-limited tests.)…”

Section: Bst Plays An Important Role In Mediating Nce and Copulationsupporting

confidence: 76%

“…Still lacking, however, is a clear account of why MPOAx males exhibit their apparent copulatory apraxia. There is no basis for rejecting the hypothesis, proffered by Giantonio et al (1970), that the MPOA is essential for integrating afferent impulses and for organizing the sequential copulatory responses; however, both the incidence of NCE and its motor pattern appeared unaltered by MPOA lesions in rats (Experiments 1-3). Similarly, rhesus males with MPOA lesions continue to engage in normal levels of apparently well coordinated masturbation (Slimp et al, 1978).…”

Section: Males With Mpoa Lesions Were Sexually Arousedmentioning

confidence: 92%

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Lesions in Medial Preoptic Area and Bed Nucleus of Stria Terminalis: Differential Effects on Copulatory Behavior and Noncontact Erection in Male Rats

1997

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The goal of these studies was to assess the regulatory roles of the medial preoptic area (MPOA) and the bed nucleus of the stria terminalis (BST) in sexual arousal, inferred from noncontact erection (NCE) evoked in male rats by remote cues from estrous females. NCE and copulatory behavior were recorded before and after quinolinic acid or radiofrequency (RF) lesions were made in the MPOA (Experiments 1-3) or RF lesions were made in the BST (Experiment 4). All males with MPOA lesions, particularly in the rostral region, displayed severe deficits in copulation but little or no decrement in NCE. In contrast, BST lesions caused relatively moderate deficits in copulation, but they severely impaired NCE. Animals with larger BST lesions, including rostral and caudal medial regions, had more deficits in both copulatory behavior and NCE than did males with smaller lesions confined to the rostral medial BST. These results suggest that (1) the MPOA is critical for copulatory behavior but not for NCE, (2) males that stop copulating after MPOA lesions are still sexually aroused by estrous females, and (3) the BST plays an important role in mediating NCE.

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Section: Bst Plays An Important Role In Mediating Nce and Copulationsupporting

confidence: 76%

Section: Males With Mpoa Lesions Were Sexually Arousedmentioning

confidence: 92%

Lesions in Medial Preoptic Area and Bed Nucleus of Stria Terminalis: Differential Effects on Copulatory Behavior and Noncontact Erection in Male Rats

1997

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“…The MeA receives sensory information from the olfactory bulbs and vomeronasal organ, processes it, and relays it to the MPOA and other sites (for review, see Kostarczyk, 1986;Wood, 1997). The MeA is important for male sexual behavior (for review, see Meisel and Sachs, 1994;Newman, 1999), because damage to the corticomedial amygdala leads to impairment of sexual behavior (Giantonio et al, 1970;Harris and Sachs, 1975;Kondo, 1992;McGregor and Herbert, 1992;Kondo and Yamanouchi, 1995;Heeb and Yahr, 2000). Exposure to an inaccessible estrous female increases noncontact erections (Kondo et al, 1999) and facilitates subsequent copulation (de Jonge et al, 1992) in males with sham lesions but not in those with MeA lesions; thus, the MeA also facilitates the response to and assimilation of sexually exciting stimuli.…”

mentioning

confidence: 99%

Regulation by the Medial Amygdala of Copulation and Medial Preoptic Dopamine Release

Domínguez

Riolo

et al. 2001

J. Neurosci.

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The medial preoptic area (MPOA) is a critical integrative site for male copulatory behavior in most vertebrate species. Extracellular dopamine (DA) is increased in the MPOA of male rats immediately before and during copulation. DA agonists microinjected into the MPOA of male rats facilitate and DA antagonists inhibit sexual behavior. A major source of input to the MPOA is the medial amygdala (MeA), which processes and relays olfactory information to the MPOA. We now report that microinjections of a DA agonist into the MPOA of animals with excitotoxic lesions of the amygdala restored copulatory ability that was lost after the lesions. Moreover, radio-frequency lesions of the MeA impaired copulation and blocked the increases in extracellular DA seen in animals with sham lesions during exposure to a receptive female and during copulation. Thus, both copulatory ability and the MPOA DA response, during exposure to a receptive female and during copulation, are facilitated by input from the MeA to the MPOA.

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“…This has also been found to be true in the rat [4,10], suggesting similar neural sites of action for these two species. Implant [25], electrical stimulation [27], and lesion [14] studies performed on adult male rats have demonstrated the importance of the preoptic area in the regulation of male sexual behavior. These devel opmental and activational findings, in conjunction with anatomical studies [11,18,20], suggest that perinatal T ex posure in the POA-AH plays a major role in the develop ment of central regulating mechanisms for mounting behav ior.…”

Section: Male Sexual Behaviormentioning

confidence: 99%

Effect of Neonatal Intrahypothalamic Testosterone Implants on Cyclicity and Adult Sexual Behavior in the Female Hamster

et al. 1981

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To localize the neural sites of hormone action for sexual differentiation in the hamster, pellets containing 3 μg testosterone were implanted directly in the preoptic area-anterior hypothalamus (POA-AH) and the ventromedial hypothalamus-arcuate regions of the hypothalamus of 3-day-old female hamsters. The POA-AH implants strongly enhanced the potential for ectopic mounts, rear mounts, and intromission patterns after adult testosterone treatment. 50% of the females with neonatal POA-AH implants demonstrated vaginal acyclicity in adulthood, suggesting a significant disruption of normal gonadotropin release. Tests for female sexual behavior revealed that implants in both POA-AH and ventromedial arcuate had no significant effect on latency to lordosis or total lordosis duration with estrogen and progesterone priming, but did reduce the longest single bout of lordosis. In conjunction with other recent investigations, these findings suggest that in the hamster, as in other species, androgenization involves several independent processes in terms of both location and sensitivity to hormone exposure.

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Effect of diencephalic and rhinencephalic lesions on the male rat's sexual behavior.

Cited by 194 publications

References 12 publications

Lesions in Medial Preoptic Area and Bed Nucleus of Stria Terminalis: Differential Effects on Copulatory Behavior and Noncontact Erection in Male Rats

Lesions in Medial Preoptic Area and Bed Nucleus of Stria Terminalis: Differential Effects on Copulatory Behavior and Noncontact Erection in Male Rats

Regulation by the Medial Amygdala of Copulation and Medial Preoptic Dopamine Release

Effect of Neonatal Intrahypothalamic Testosterone Implants on Cyclicity and Adult Sexual Behavior in the Female Hamster

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