Effect of diazepam on the fatty acid composition of plasma and liver phospholipids in rat

Ristic, V.; Vrbaski, S. R.

doi:10.1016/0885-4505(92)90026-u

Cited by 3 publications

(1 citation statement)

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“…Methyl esters of phospholipid fatty acids (from plasma and erythrocytes) were preparated by methods reported previously. [23] Fatty acid methyl esters derivatives formed from isolated plasma phospholipid fraction were separated by gas chromatography using a Varian GC (model 3400, Varian Associates) as described. [24] Individual fatty acid methyl esters in the sample were identified from the retention times of authentic standards (Sigma Chemical Co) and/ or polyunsaturated fatty acids (PUFA-2) mixture (Supelco Inc., Bellefonte).…”

Section: Biochemical Determinationmentioning

confidence: 99%

Plasma and Erythrocyte Phospholipid Fatty Acids Composition in Serbian Hemodialyzed Patients

et al. 2006

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Dyslipidemia is one of the possible risk factors for advanced atherosclerosis in patients with chronic renal failure. Abnormal phospholipid metabolism may play an important role in the progression of atherosclerosis in patients with renal failure. The aim of this study was to determine specific characteristics of plasma and erythrocyte phospholipid content and fatty acid composition in 37 patients with chronic renal failure on hemodialysis (HD). The results were compared with the characteristics of healthy subjects. Briefly, plasma triglyceride (p < 0.001), total cholesterol (p < 0.05), and total phospholipids (p < 0.01) levels were significantly higher and HDL-cholesterol level significantly lower (p < 0.01) in HD patients. Plasma phosphatidylcholine and phosphatidylethanolamine concentration were significantly higher (p < 0.001) in HD patients. The plasma phospholipid fatty acids composition indicated significantly (p < 0.01) higher level of oleic (18:1 n-9) and lower levels of eicopentaenoic (20:5 n-3 EPA) and docosahexaenoic (22:6 n-3 DHA) acids (p < 0.05). However, in HD patients, the relative concentration of plasma phospholipid n-6 polyunsaturated fatty acid (PUFA) was significantly lower (p < 0.05). The fatty acid composition of erythrocyte phospholipid in HD patients was modified with EPA and DHA levels significantly lowered (p < 0.05). Our results demonstrate an abnormal phospholipid metabolism and deficiency of n-3 PUFA in plasma and erythrocyte phospholipids in hemodialyzed patients.

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Section: Biochemical Determinationmentioning

confidence: 99%