Effect of Diazepam and Sex Hormones on Eeg of Gonadectomized Male and Female Rats

Ugalde, Edmundo Granda; Río-Portilla, Irma Yolanda del; Juárez, José Antonio Caballero; Roldán, Aurora González; Guevara, Miguel Ángel; Corsi-Cabrera, María

doi:10.1016/s0306-4530(98)00035-3

Cited by 10 publications

(2 citation statements)

References 33 publications

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“…This implies a weakening of prefrontal – hippocampal network coupling under diazepam and strengthening of the same under ketamine. Reductions in intra-hemispheric Theta and Alpha coherence have been observed in awake humans in response to diazepam 40 , while decreased inter-parietal coherence has been reported in rats 41 . The descent into NREM sleep is associated with a reduction in cortical connectivity and eventually a functional decoupling of the prefrontal cortex 42 – 44 .…”

Section: Discussionmentioning

confidence: 95%

Detection of time-, frequency- and direction-resolved communication within brain networks

Crouch

Sommerlade

Veselcic

et al. 2018

Sci Rep

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Electroencephalography (EEG) records fast-changing neuronal signalling and communication and thus can offer a deep understanding of cognitive processes. However, traditional data analyses which employ the Fast-Fourier Transform (FFT) have been of limited use as they do not allow time- and frequency-resolved tracking of brain activity and detection of directional connectivity. Here, we applied advanced qEEG tools using autoregressive (AR) modelling, alongside traditional approaches, to murine data sets from common research scenarios: (a) the effect of age on resting EEG; (b) drug actions on non-rapid eye movement (NREM) sleep EEG (pharmaco-EEG); and (c) dynamic EEG profiles during correct vs incorrect spontaneous alternation responses in the Y-maze. AR analyses of short data strips reliably detected age- and drug-induced spectral EEG changes, while renormalized partial directed coherence (rPDC) reported direction- and time-resolved connectivity dynamics in mice. Our approach allows for the first time inference of behaviour- and stage-dependent data in a time- and frequency-resolved manner, and offers insights into brain networks that underlie working memory processing beyond what can be achieved with traditional methods.

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Section: Discussionmentioning

confidence: 95%

Detection of time-, frequency- and direction-resolved communication within brain networks

Crouch

Sommerlade

Veselcic

et al. 2018

Sci Rep

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“…Durante reposo con ojos abiertos sólo las mujeres mostraron un decremento de la potencia de theta y alfa 2. Esta disminución de theta encontrada en mujeres y no en hombres concuerda con los datos encontrados en ratas hembras gonadectomizadas sin tratamiento hormonal y en ratas hembras gonadectomizadas recibiendo progesterona pero no entre los machos (Ugalde et al 1998). En contraste, la correlación interhemisférica se vio más afectada en los hombres, quienes mostraron un decremento de la correlación interhemisférica de alfa 1.…”

Section: Influencias Hormonales Versus Genéticasunclassified

Correlatos neurales del seguimiento de reglas complejas bajo el efecto del diazepam en hombres y mujeres

Torres¹

2011

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Este trabajo se realizó con la participación de personas muy valiosas a quienes a continuación quiero expresar mi agradecimiento: A la Dra. Mary Corsi, por tu dirección ininterrumpida en esta investigación y por constituir un pilar fundamental en mi formación en el ámbito neurocientífico. El conocimiento que me brindaste me acompañará por siempre, gracias por darme la oportunidad de aprender a tu lado.A los miembros de mi comité tutoral quienes estuvieron presentes durante el proceso de este proyecto:Dra. Thalía Harmony, por sus ideas y conocimiento vertidos en el mejoramiento de esta investigación.

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Prefrontal activity decline in women under a single dose of diazepam during rule-guided responses: an fMRI study

et al. 2016

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Daily life events confront us with new situations demanding responses to usual and unusual rules. Diazepam (DZ), a clinically important drug, facilitates the inhibitory activity of the GABAergic system. Prefrontal cortex, rich in DZ receptors, coordinates necessary resources to direct actions according to rules. The balance between excitatory and inhibitory activity is critical to achieve optimal function of brain systems leading to complex functions. Major sex differences in the physiological mechanisms of the GABAergic system have been reported. However, the differential influence of DZ on men and women in neural activity during behavior directed by frontal lobes remains unexplored. The ability of healthy volunteers to select responses following usual/congruent and novel/incongruent rules, and brain correlates were measured with fMRI under the administration of DZ and a placebo. 10 mg of DZ was enough to decrease the performance in a different manner between men and women. While reaction times increased in both men and women, women committed more errors selecting responses than men under DZ. Men demonstrated increased activity, while women demonstrated decreased activity in frontal regions involved in response selection of rules. These findings could have important consequences in understanding the differential influences of DZ between the sexes in complex daily life situations. More importantly, this study emphasizes the importance of understanding the differential effects on men and women of drugs widely employed by society, thereby achieves better therapeutic results and avoids side effects that the present study revealed to be different between sexes.

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Effect of Diazepam and Sex Hormones on Eeg of Gonadectomized Male and Female Rats

Cited by 10 publications

References 33 publications

Detection of time-, frequency- and direction-resolved communication within brain networks

Detection of time-, frequency- and direction-resolved communication within brain networks

Correlatos neurales del seguimiento de reglas complejas bajo el efecto del diazepam en hombres y mujeres

Prefrontal activity decline in women under a single dose of diazepam during rule-guided responses: an fMRI study

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